Higher Inflammatory Markers are correlated with Worse Cognitive Function in Coronavirus Disease-2019 Patients

Authors

  • Fasihah Irfani Fitri Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik General Hospital Medan Indonesia, Medan, Indonesia https://orcid.org/0000-0002-0883-3029
  • Winda Rahmah Darman Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik General Hospital Medan Indonesia, Medan, Indonesia
  • Kiking Ritarwan Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Adam Malik General Hospital Medan Indonesia, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9472

Keywords:

COVID-19, C-reactive protein, Cognitive, D-Dimer, Ferritin, Inflammation

Abstract

AIM: This study aimed to determine the correlation between inflammation with cognitive function in COVID-19 patients.

METHODS: We recruited COVID-19 patients using consecutive sampling methods in Adam Malik General Hospital Medan, Indonesia. The neutrophil-to-lymphocyte ratio (NLR,) C-reactive protein (CRP), D-dimer, and ferritin serum levels were measured as inflammatory markers . Cognitive function was assessed in several cognitive domains using Forward Digit Span for attention, Bacward Digit Span for working memory, and Trail Making Test parts A and B for executive function. The correlation between inflammatory markers and cognitive function was analyzed using Spearman correlation test.

RESULTS: This study involved 40 COVID-19 patients consisting of 13 (32.5%) males and 27 (67.5%) females; the median age of the patients was 39.5 (19–65) years. We found that higher D-dimer and ferritin levels were significantly correlated with worse BDS scores (r = −0.369 p = 0.019 and r = −0.408 p = 0.009, respectively) and higher ferritin level was also correlated with worse FDS score (r = −0.365 p = 0.020 and). Higher D-dimer and ferritin levels were also significantly correlated with a longer time of completion of TMT-B (r = 0.363 p = 0.022 and r = 0.433 p = 0.005) and higher ferritin level was also correlated with a longer time of completion of TMT-A (r = 0.438 P=0.005). There were no significant correlations between NLR and CRP levels with cognitive function.

CONCLUSION: Higher inflammatory markers are correlated with worse attention, working memory, and executive function in COVID-19 patients.

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References

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Published

2022-04-22

How to Cite

1.
Fitri FI, Darman WR, Ritarwan K. Higher Inflammatory Markers are correlated with Worse Cognitive Function in Coronavirus Disease-2019 Patients. Open Access Maced J Med Sci [Internet]. 2022 Apr. 22 [cited 2024 Apr. 21];10(B):1206-11. Available from: https://oamjms.eu/index.php/mjms/article/view/9472

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