Herbal Medicine on Response Immune Patient with COVID-19 Infection a Scoping Review


  • Winda Rofiyati Department of Medical Surgical Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia https://orcid.org/0000-0003-2568-4093
  • Hamam Hadi Department of Nutrition, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia https://orcid.org/0000-0002-1945-2539
  • Ratna Wirawati Rosyada Department of Medical Surgical Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia
  • Tengku Isni Yuli Letari Putri Department of Emergency Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia
  • Muhammad G. A. Putra Department of Medical Surgical Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia https://orcid.org/0000-0002-4187-3647
  • Indah Ayuningtyas Department of Student of Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia
  • Mulyanti Mulyanti Department of Community and Family Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia




Herbal medicine, COVID-19, Citokine storm


BACKGROUND: COVID-19 has spread through the world and has caused a global pandemic. There is a lot of evidence that taking herbal medicines could increase the immune response but otherwise, the relation of herbal medicine and inflammation factors that lead to cytokine storm is still discussing.

AIM: The purpose of this article is to review the evidence of herbal medicine that use in COVID-19 patients and the effect on the immune response of patients with COVID-19 infection.

METHOD: We conducted a scoping review on the PubMed and Science Direct databases from January 1 to July 2020 using searching terms “COVID-19”, “SARS-CoV2 Infection”, “Herbal Medicine” AND “Immune Response” Or “Humoral Immune, Response”. We use only scientific articles that discuss herbal medicine and its effect on the immune response. There were eight articles included in the analysis, many types of herbal medicines are used to maintain symptom management and to enhance the patient’s immune response, including, Echinacea, QPD (qingfei paidu) and Western medicine, Jiedu Capsule (SFJDC), Yidu-toxicity blocking lung decoction and Ayush Kwath, nagella sative, and LHQW.

RESULTS: This article concludes that several alternative herbal medicines affect the immune response in COVID-19 patients, especially in reducing inflammatory agents, cytokine levels, and immunomodulators. Echinacea, Jiedu Capsule (SFJD), QPD (qingfei paidu) and Western medicine, and Ayush Kwath, nagella sative, and Lianhuaqingwen (LHQW) are the alternative herbal medicines that could provide benefits for COVID-19 patients, although research on the target mechanism must need more exploration.


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How to Cite

Rofiyati W, Hadi H, Rosyada RW, Putri TIYL, Putra MGA, Ayuningtyas I, Mulyanti M. Herbal Medicine on Response Immune Patient with COVID-19 Infection a Scoping Review. Open Access Maced J Med Sci [Internet]. 2022 Jan. 3 [cited 2023 Sep. 27];10(T8):155-9. Available from: https://oamjms.eu/index.php/mjms/article/view/9489

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