Herbal Medicine on Response Immune Patient with COVID-19 Infection a Scoping Review

Authors

  • Winda Rofiyati Department of Medical Surgical Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia https://orcid.org/0000-0003-2568-4093
  • Hamam Hadi Department of Nutrition, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia https://orcid.org/0000-0002-1945-2539
  • Ratna Wirawati Rosyada Department of Medical Surgical Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia
  • Tengku Isni Yuli Letari Putri Department of Emergency Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia
  • Muhammad G. A. Putra Department of Medical Surgical Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia https://orcid.org/0000-0002-4187-3647
  • Indah Ayuningtyas Department of Student of Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia
  • Mulyanti Mulyanti Department of Community and Family Nursing, Faculty of Health Science, Universitas Alma Ata, Yogyakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9489

Keywords:

Herbal medicine, COVID-19, Citokine storm

Abstract

BACKGROUND: COVID-19 has spread through the world and has caused a global pandemic. There is a lot of evidence that taking herbal medicines could increase the immune response but otherwise, the relation of herbal medicine and inflammation factors that lead to cytokine storm is still discussing.

AIM: The purpose of this article is to review the evidence of herbal medicine that use in COVID-19 patients and the effect on the immune response of patients with COVID-19 infection.

METHOD: We conducted a scoping review on the PubMed and Science Direct databases from January 1 to July 2020 using searching terms “COVID-19”, “SARS-CoV2 Infection”, “Herbal Medicine” AND “Immune Response” Or “Humoral Immune, Response”. We use only scientific articles that discuss herbal medicine and its effect on the immune response. There were eight articles included in the analysis, many types of herbal medicines are used to maintain symptom management and to enhance the patient’s immune response, including, Echinacea, QPD (qingfei paidu) and Western medicine, Jiedu Capsule (SFJDC), Yidu-toxicity blocking lung decoction and Ayush Kwath, nagella sative, and LHQW.

RESULTS: This article concludes that several alternative herbal medicines affect the immune response in COVID-19 patients, especially in reducing inflammatory agents, cytokine levels, and immunomodulators. Echinacea, Jiedu Capsule (SFJD), QPD (qingfei paidu) and Western medicine, and Ayush Kwath, nagella sative, and Lianhuaqingwen (LHQW) are the alternative herbal medicines that could provide benefits for COVID-19 patients, although research on the target mechanism must need more exploration.

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References

Arksey H, O’Malley L. Scoping studies: Towards a methodological framework. Int J Res Methodol. 2005;8(1):19-32. https://doi.org/10.1080/1364557032000119616

World Health Organization. WHO Guidelines for Assessing Quality of Herbal Medicines with Reference to Contaminants and Residues. Geneva: World Health Organization; 2007. Available from: https://www.who.int/publications/i/item/9789241594448. [Last accessed on 2021 Jan 25].

Emelda E. Potential Tongkat Ali (Eurycoma longifolia Jack.) as anti-inflammatory. JCPS. 2017;1(1):25-9.

Aucoin M, Cooley K, Saunders PR, Carè J, Anheyer D, Medina DN, et al. The effect of Echinacea spp. on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: A rapid review. Adv Integr Med. 2020;7(4):203-17. https://doi.org/10.1016/j.aimed.2020.07.004 PMid:32837894

Xin S, Cheng X, Zhu B, Liao X, Yang F, Song L, et al. Clinical retrospective study on the efficacy of Qingfei paidu decoction combined with Western medicine for COVID-19 treatment. Biomed Pharmacother. 2020;129:110500. https://doi.org/10.1016/j.biopha.2020.110500 PMid:32768975

Zhao J, Yang X, Wang C, Song S, Cao K, Wei T, et al. Yidu-toxicity blocking lung decoction ameliorates inflammation in severe pneumonia of SARS-COV-2 patients with Yidu-toxicity blocking lung syndrome by eliminating IL-6 and TNF-a. Biomed Pharmacother. 2020;129:110436. https://doi.org/10.1016/j.biopha.2020.110436 PMid:32768938

Gautam S, Gautam A, Chhetri S, Bhattarai U. Immunity against COVID-19: Potential role of Ayush Kwath. J Ayurveda Integr Med. 2020;13(1):100350. https://doi.org/10.1016/j.jaim.2020.08.003 PMid:32837101

Nugraha RV, Ridwansyah H, Ghozali M, Khairani AF, Atik N. Traditional herbal medicine candidates as complementary treatments for COVID-19: A review of their mechanisms, pros and cons. J Evid Based Complement Altern Med. 2020;2020:2560645. https://doi.org/10.1155/2020/2560645 PMid:33101440

Dwinta E. Increasing public health knowledge and awareness O antimicrobial resistance with radio communication media. Educ Commu Serv. 2021;1(1):218.

Kusumawardani N. Anti-inflammatory test of ethanol-hexane fraction of methanol-water extract of Macaranga tanarius L. leaf on carrageenin induced swiss strain mice. Essay. 2015. Available from: https://repository.usd.ac.id/2536/2/128114081_full.pdf Its unpublished article in a respository.

Bordoni L, Fedeli D, Nasuti C, Maggi F, Papa F, Wabitsch M, et al. Antioxidant and anti-inflammatory properties of nigella sativa oil in human pre-adipocytes. Antioxidants. 2019;8(2):51. https://doi.org/10.3390/antiox8020051 PMid:30823525

Liu W, Guan WJ, Zhong NS. Strategies and advances in combating COVID-19 in China. Engineering. 2020;6(10):1076-84. https://doi.org/10.1002/14651858.CD004882.pub3 PMid:33078078

Liu X, Zhang M, He L, Li Y. Chinese herbs combined with Western medicine for severe acute respiratory syndrome (SARS). Cochrane Database Syst Rev. 2012;10(10):CD004882-CD. https://doi.org/10.1002/14651858.CD004882.pub3 PMid:23076910

Ang L, Lee HW, Kim A, Lee JA, Zhang J, Lee MS. Herbal medicine for treatment of children diagnosed with COVID-19: A review of guidelines. Complement Ther Clin Pract. 2020;39:101174. https://doi.org/10.1016/j.ctcp.2020.101174 PMid:32379639

Tao Z, Zhang L, Friedemann T, Yang G, Li J, Wen Y, et al. Systematic analyses on the potential immune and anti-inflammatory mechanisms of Shufeng Jiedu capsule against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused pneumonia. J Funct Foods. 2020;75:104243. https://doi.org/10.1016/j.jff.2020.104243 PMid:33072190

Maideen NM. Correction: Prophetic medicine-Nigella sativa (black Cumin Seeds) Potential Herb for COVID-19. J Pharmacopuncture. 2020;23(3):179. https://doi.org/10.3831/KPI.2020.23.010 PMid:33072416

Li LC, Zhang ZH, Zhou WC, Chen J, Jin HQ, Fang HM, et al. Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19) treatment: Advances and prospects. Biomed Pharmacother. 2020;130:110641. https://doi.org/10.1016/j.biopha.2020.110641 PMid:34321172

Xiong WZ, Wang G, Du J, Ai W. Efficacy of herbal medicine (Xuanfei baidu decoction) combined with conventional drug in treating COVID-19: A pilot randomized clinical trial. Integr Med Res. 2020;9(3):100489. https://doi.org/10.1016/j.imr.2020.100489 PMid:32874913

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Published

2022-01-03

How to Cite

1.
Rofiyati W, Hadi H, Rosyada RW, Putri TIYL, Putra MGA, Ayuningtyas I, Mulyanti M. Herbal Medicine on Response Immune Patient with COVID-19 Infection a Scoping Review. Open Access Maced J Med Sci [Internet]. 2022 Jan. 3 [cited 2022 Oct. 1];10(T8):155-9. Available from: https://oamjms.eu/index.php/mjms/article/view/9489

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