Improving Diabetic Foot Ulcer Healing with Adjuvant Bitter Melon Leaf Extract (Momordica charantia L.)

Authors

  • Fahrun Nur Rosyid Department of Medical Surgical Nursing, School of Nursing, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia
  • Muhtadi Muhtadi Department of Pharmacy, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia https://orcid.org/0000-0001-6642-8040
  • Dian Hudiyawati Department of Medical Surgical Nursing, School of Nursing, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia https://orcid.org/0000-0002-4585-1728
  • Sugiyarti Sugiyarti Department of Medical Surgical Nursing, General Hospital, Surakarta, Indonesia
  • Ahmad Fadhlur Rahman Department of Medical Surgical Nursing, School of Nursing, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia https://orcid.org/0000-0002-3107-3435

DOI:

https://doi.org/10.3889/oamjms.2022.9503

Keywords:

Bitter melon, Momordica charantia L, Diabetic foot ulcer, Ulcer healing

Abstract

BACKGROUND: Diabetes mellitus is a serious disease that affects more than 340 million people and causes approximately 20% of diabetic ulcer cases worldwide. Wound healing is a complex and dynamic process in restoring cellular structures and tissue layers. It consists of four continuous overlapping phases that are precisely programmed

AIM: This study aims to examine the adjuvant administration of bitter melon leaf extract to increase the healing of diabetic foot ulcers (DFU).

METHODS: This study used a randomized, double-blind, and placebo-controlled trial. A total of 30 DFU patients with a perfusion, extent, depth, infection, and sensation (PEDIS) score of 1–8 who met the criteria were divided into two groups, namely, the treatment group with adjuvant administration of bitter melon leaf extract at a dose of 6 g/day as many as 15 patients and the control group 15 patients with placebo. This intervention was carried out for 4 weeks. DFU cure was measured by PEDIS scores at baseline, weeks 2, 3, and the end of week 4. Data were analyzed using paired t-test and independent t-test.

RESULTS: After 4 weeks of treatment, the PEDIS score in the treatment group decreased at week 2 (0.9 ± 1.8), but not significant (p = 0.19), decreased at week 3 (1.9 ± 1.9) and significant (p = 0.01), decreased in week IV (2.3 ± 2.1) and significantly (p = 0.001). The control group experienced a decrease in week 2 (0.3 ± 2.3), but not significant (p = 0.71), decreased in week 3 (1.2 ± 2.5), but not significant (p = 0.18), decreased in week 4 (1.9 ± 2.7) and significantly (p = 0.03), and there was an effect of adjuvant administration of bitter melon leaf extract on the cure of DFU (p = 0.004).

CONCLUSION: Adjuvant administration of bitter melon leaf extract has been shown to increase the healing of DFU.

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Published

2022-01-03

How to Cite

1.
Rosyid FN, Muhtadi M, Hudiyawati D, Sugiyarti S, Rahman AF. Improving Diabetic Foot Ulcer Healing with Adjuvant Bitter Melon Leaf Extract (Momordica charantia L.). Open Access Maced J Med Sci [Internet]. 2022 Jan. 3 [cited 2022 May 21];10(T8):122-6. Available from: https://oamjms.eu/index.php/mjms/article/view/9503