Solid Dispersion of Tenoxicam – HPMC by Freeze-Drying: Solid State Properties, Dissolution Study, and Analgesic Activity in Mice

Salman Umar; Hendrizal Usman; Hulwa Salsabila; Erizal Zaini

doi:10.3889/oamjms.2022.9553

Authors

Salman Umar Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Padang 25163, Indonesia
Hendrizal Usman Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Padang 25163, Indonesia
Hulwa Salsabila Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Padang 25163, Indonesia https://orcid.org/0000-0001-9723-3027
Erizal Zaini Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Padang 25163, Indonesia https://orcid.org/0000-0003-0108-4464

DOI:

https://doi.org/10.3889/oamjms.2022.9553

Keywords:

Analgesic, Dissolution rate, Freeze-drying, HPMC, Solid dispersion, Solubility, Tenoxicam

Abstract

AIM: The aim of this study was to prepare solid dispersion of tenoxicam with hydroxypropyl methylcellulose (HPMC) to improve solubility, dissolution rate, and in vivo analgesic activity.

METHODS: Solid dispersion of tenoxicam with HPMC was prepared using the freeze-drying technique in three ratios of drug to carrier (1:1, 1:2, and 2:1 w/w). The s olid-state properties of solid dispersion powders were characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, and scanning electron microscope (SEM). Solubility and dissolution rate studies were conducted in an aqueous medium. Analgesic activity was evaluated using the writhing method.

RESULTS: Analysis of PXRD and DSC results indicated a decreased degree of crystallinity of tenoxicam in solid dispersion powders. Solid dispersion of tenoxicam exhibited a significant improvement in solubility and dissolution rate compared to intact tenoxicam, in line to the increment on the ratio of HPMC. Analgesic activity study revealed that solid dispersion 1:2 was more effective than intact tenoxicam.

CONCLUSIONS: This study concludes that the solid dispersion technique is a promising strategy to improve the solubility and dissolution rate of tenoxicam.

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