Potential Protective Effect of Zingiber officinale in Comparison to Rosuvastatin on High-fat diet-induced Non-alcoholic Fatty Liver Disease in Rats

Osama Ibrahim Ramadan; Mohamed Nasr; Osama M.M. Abd El-Hay; Abdulkarim Hasan; Ezz-Eldin E. Abd-Allah; Mohammed E.  Mahmoud; Fatma M. Abd-Allah; Tamer M. M. Abuamara; Mohammed G. A. Hablas; Moaaz M. Y. Awad; Mahmoud Diab; Ahmed M. Taha; Mohamed K. Radwan; Nancy H. Abulkhair; Alsayed A. Abdel-Hady

doi:10.3889/oamjms.2022.9643

Authors

Osama Ibrahim Ramadan Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt https://orcid.org/0000-0002-7916-5494
Mohamed Nasr Department of Histology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
Osama M.M. Abd El-Hay Department of Physiology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
Abdulkarim Hasan Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Ezz-Eldin E. Abd-Allah Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Mohammed E. Mahmoud Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Fatma M. Abd-Allah Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Tamer M. M. Abuamara Department of Histology, Faculty of Medicine, Al Azhar University, Cairo, Egypt
Mohammed G. A. Hablas Department of Histology, Assiut Faculty of Medicine, Al Azhar University, Cairo, Egypt
Moaaz M. Y. Awad Department of Anatomy and Embryology, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Mahmoud Diab Department of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Ahmed M. Taha Department of Pharmacology, Faculty of Medicine, Helwan University, Helwan, Egypt
Mohamed K. Radwan Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Nancy H. Abulkhair Department of Biochemistry, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt
Alsayed A. Abdel-Hady Department of Anatomy and Embryology, Faculty of Medicine, Helwan University, Helwan, Egypt

DOI:

https://doi.org/10.3889/oamjms.2022.9643

Keywords:

Zingiber officinale, Rosuvastatin, Ginger, Non-alcoholic Fatty Liver Disease

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease affecting nearly 25% of adults worldwide with related risk factors including obesity, metabolic, and inflammatory diseases. Many therapeutic remedies of natural or synthetic properties were used.

AIM: This study aimed to investigate and compare the effects of ginger/rosuvastatin (ROSU) on the liver of rats with induced NAFLD.

MATERIALS AND METHODS: Forty adult male albino rats were used in this study and divided into four equal subgroups, Group I, control received the standard rat chow diet and given normal saline (1 ml/kg/day), Group II, high-fat diet (HFD) group, Group III, received HFD+ ROSU (15 mg/kg/day), and Group IV, HFD+ Zingiber officinale (10% W/V) for 6 weeks. At the end of our experiment, the rats were sacrificed then blood samples were collected for biochemical analysis of lipid profiles and liver enzymes, liver specimen was prepared for light and electron microscopic examination, and measurement of tissue level of malondialdehyde.

RESULTS: NAFLD caused degenerative changes and lipid deposition in liver cells as evidenced by microscopic results and laboratory tests. Treatment with ginger/ROSU alleviated those changes.

CONCLUSION: Ginger and ROSU could ameliorate liver functions in NAFLD and ginger effect is superior to ROSU.

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