The Effect of Hydrogen Peroxide and Povidone-Iodine on the Shear Bond Strength of Orthodontic Brackets: An In Vitro Study
DOI:
https://doi.org/10.3889/oamjms.2022.9662Keywords:
Mouthwashes, Shear bond strengths, COVID-19, Povidone-iodine, Hydrogen peroxideAbstract
BACKGROUND: Chlorhexidine, which is the gold-standard antimicrobial mouthwash, cannot effectively decrease the count of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent for coronavirus disease-2019 (COVID-19). Since SARS-CoV-2 is susceptible to oxidation, mouthwashes containing oxidizing agents such as hydrogen peroxide (H2O2) or Povidone-iodine (PVP-I) are recommended to decrease the viral count.
AIM: This study aimed to assess the effects of H2O2 and PVP-I mouthwashes on the shear bond strength (SBS) of metal orthodontic brackets to the enamel.
MATERIALS AND METHODS: This in vitro experimental study evaluated 45 freshly extracted maxillary premolars. The teeth were cleaned and randomized into three groups (n = 15) for rinsing with distilled water (control group), 1% PVP-I (betadine), and 1.5% H2O2 for 60 s. All teeth were etched with 37% phosphoric acid gel, and metal orthodontic brackets were bonded to the teeth using the Transbond XT bonding system. The teeth were mounted in auto-polymerized acrylic resin and incubated in water at 37°C for 72 h. The teeth were then thermocycled for 48 h, and their SBS was measured in a universal testing machine. The adhesive remnant index (ARI) score was also calculated. The groups were compared by ANOVA and Chi-square Monte Carlo test.
RESULTS: No significant difference was noted among the three groups in SBS (p = 0.938) or the ARI score (p = 0.780).
CONCLUSION: Use of H2O2 and PVP-I mouthwashes has no adverse effect on SBS or mode of failure of metal orthodontic brackets bonded to enamel.Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol. 2020;92(4):401-2. https://doi.org/10.1002/jmv.25678 PMid:31950516 DOI: https://doi.org/10.1002/jmv.25678
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. https://doi.org/10.1016/s0140-6736(20)30183-5 PMid:31986264 DOI: https://doi.org/10.1016/S0140-6736(20)30183-5
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. https://doi.org/10.1056/NEJMoa2002032 DOI: https://doi.org/10.1056/NEJMoa2002032
Monaghan NP. Emerging infections-implications for dental care. Br Dent J. 2016;221(1):13-5. https://doi.org/10.1038/sj.bdj.2016.486 PMid:27388077 DOI: https://doi.org/10.1038/sj.bdj.2016.486
Reardon S. How the Delta variant achieves its ultrafast spread. Nature. 2021;21(3). https://doi.org/10.1038/d41586-021-01986-w PMid:34290423 DOI: https://doi.org/10.1038/d41586-021-01986-w
Raghunath N, Meenakshi S, Sreeshyla HS, Priyanka N. Aerosols in dental practice-A neglected infectious vector. Microbiol Res J Int. 2016;14(2):1-8. https://doi.org/10.9734/bmrj/2016/24101 DOI: https://doi.org/10.9734/BMRJ/2016/24101
James R, Mani A. Dental aerosols: A silent hazard in dentistry. Int J Sci Res. 2016;5(11):1761-3.
Bentley CD, Burkhart NW, Crawford JJ. Evaluating spatter and aerosol contamination during dental procedures. J Am Dent Assoc. 1994;125(5):579-84. https://doi.org/10.14219/jada.archive.1994.0093 PMid:8195499 DOI: https://doi.org/10.14219/jada.archive.1994.0093
Ge ZY, Yang LM, Xia JJ, Fu XH, Zhang YZ. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B. 2020;21(5):361-8. https://doi.org/10.1631/jzus.b2010010 PMid:32425001 DOI: https://doi.org/10.1631/jzus.B2010010
Gupta G, Mitra D, Ashok KP, Gupta A, Soni S, Ahmed S, et al. Efficacy of preprocedural mouth rinsing in reducing aerosol contamination produced by ultrasonic scaler: A pilot study. J Periodontol. 2014;85(4):562-8. https://doi.org/10.1902/jop.2013.120616 PMid:23855840 DOI: https://doi.org/10.1902/jop.2013.120616
Feres M, Figueiredo LC, Faveri M, Stewart B, de Vizio W. The effectiveness of a preprocedural mouthrinse containing cetylpyridinium chloride in reducing bacteria in the dental office. J Am Dent Assoc. 2010;141(4):415-22. https://doi.org/10.14219/jada.archive.2010.0193 PMid:20354090 DOI: https://doi.org/10.14219/jada.archive.2010.0193
Kaur R, Singh I, Vandana KL, Desai R. Effect of chlorhexidine, povidone iodine, and ozone on microorganisms in dental aerosols: Randomized double-blind clinical trial. Indian J Dent Res. 2014;25(2):160-5. https://doi.org/10.4103/0970-9290.135910 PMid:24992844 DOI: https://doi.org/10.4103/0970-9290.135910
Marui VC, Souto ML, Rovai ES, Romito GA, Chambrone L, Pannuti CM, et al. Efficacy of preprocedural mouthrinses in the reduction of microorganisms in aerosol: A systematic review. J Am Dent Assoc. 2019;150(12):1015-26. https://doi.org/10.1016/j.adaj.2019.06.024 PMid:31761015 DOI: https://doi.org/10.1016/j.adaj.2019.06.024
Centers for Disease Control and Prevention. Interim Infection Prevention and Control Recommendations for Patients with Confirmed 2019 Novel Coronavirus (2019-nCoV) or Persons under Investigation for 2019-nCoV in Healthcare Settings. Atlanta, Georgia: Centers for Disease Control and Prevention; 2020. Available from: https://www.cdc.gov/coronavirus/2019-nCoV/hcp/infection-control.html [Last accessed on 2020 Feb 12].
Vergara-Buenaventura A, Castro-Ruiz C. Use of mouthwashes against COVID-19 in dentistry. Br J Oral Maxillofac Surg. 2020;58(8):924-7. https://doi.org/10.1016/j.bjoms.2020.08.016 PMid:32859459 DOI: https://doi.org/10.1016/j.bjoms.2020.08.016
DevKumar G, Mishra A, Dunn L, Townsend A, Oguadinma IC, Bright KR, et al. Biocides and novel antimicrobial agents for the mitigation of coronaviruses. Front Microbiol. 2020;11:1351. https://doi.org/10.3389/fmicb.2020.01351 PMid:32655532 DOI: https://doi.org/10.3389/fmicb.2020.01351
Vargas-Buratovic JP, Verdugo-Paiva F, Véliz-Paiva C, López- Tagle E, Ahumada-Salinas A, Ortuño-Borroto D. Dental recommendations in the COVID-19 pandemic: A narrative review. Medwave. 2020;20(4):e7916. https://doi.org/10.5867/medwave.2020.05.7916 PMid:32678809 DOI: https://doi.org/10.5867/medwave.2020.05.7916
Anderson DE, Sivalingam V, Kang AE, Ananthanarayanan A, Arumugam H, Jenkins TM, et al. Povidone-iodine demonstrates rapid in vitro virucidal activity against SARS-CoV-2, the virus causing COVID-19 disease. Infect Dis Ther. 2020;9(3):669-75. https://doi.org/10.21203/rs.3.rs-34544/v2 PMid:32643111 DOI: https://doi.org/10.1007/s40121-020-00316-3
Frank S, Capriotti J, Brown SM, Tessema B. Povidone-iodine use in sinonasal and oral cavities: A review of safety in the COVID-19 era. Ear Nose Throat J. 2020;99(9):586-93. https://doi.org/10.1177/0145561320932318 PMid:32520599 DOI: https://doi.org/10.1177/0145561320932318
Caruso AA, Del Prete A, Lazzarino AI. Hydrogen peroxide and viral infections: A literature review with research hypothesis definition in relation to the current covid-19 pandemic. Med Hypotheses. 2020;144:109910. https://doi.org/10.1016/j.mehy.2020.109910 PMid:32505069 DOI: https://doi.org/10.1016/j.mehy.2020.109910
Fernandez MD, Guedes MI, Langa GP, Rösing CK, Cavagni J, Muniz FW. Virucidal efficacy of chlorhexidine: A systematic review. Odontology. 2021;110(2)1-7. https://doi.org/10.1007/s10266-021-00660-x PMid:34637092 DOI: https://doi.org/10.1007/s10266-021-00660-x
Kutuk ZB, Oz A, Yazici AR. Influence of preprocedural antiseptic mouthrinses against COVID-19 on enamel/dentin bond strength of a universal adhesive. J Adhesion Sci Technol. 2021;35(21):2288-300. https://doi.org/10.1080/01694243.2021.1885904 DOI: https://doi.org/10.1080/01694243.2021.1885904
Jamilian A, Saghiri MA, Ghasemi M, Ghasemian A, Borna N, Kamali Z. The effects of two mouth rinses on shear bond strength of orthodontic brackets: An in-vitro study. Virtual J Orthod. 2011;1:1-7.
Zachrisson BU. A posttreatment evaluation of direct bonding in orthodontics. Am J Orthod. 1977;71(2):173-89. https://doi.org/10.1016/s0002-9416(77)90394-3 PMid:319678 DOI: https://doi.org/10.1016/S0002-9416(77)90394-3
O’brien KD, Read MJ, Sandison RJ, Roberts CT. A visible light-activated direct-bonding material: An in vivo comparative study. Am J Orthod Dentofacial Orthoped. 1989;95(4):348-51. https://doi.org/10.1016/0889-5406(89)90169-8 PMid:2650532 DOI: https://doi.org/10.1016/0889-5406(89)90169-8
Penugonda B, Settembrini L, Scherer W, Hittelman E, Strassler H. Alcohol-containing mouthwashes: Effect on composite hardness. J Clin Dent. 1994;5(2):60-2. PMid:7999290
Weiner R, Millstein P, Hoang E, Marshall D. The effect of alcoholic and nonalcoholic mouthwashes on heat-treated composite resin. Oper Dent. 1997;22:249-53. PMid:9610321
Imani MM, Azizi F, Bahrami K, Golshah A, Safari-Faramani R. In vitro bleaching effect of hydrogen peroxide with different time of exposition and concentration on shear bond strength of orthodontic brackets to human enamel: A meta-analysis of in vitro studies. Int Orthod. 2020;18(1):22-31. https://doi.org/10.1016/j.ortho.2019.09.001 PMid:31629708 DOI: https://doi.org/10.1016/j.ortho.2019.09.001
Çatalbas B, Ercan E, Erdemir A, Gelgor IE, Zorba YO. Effects of different chlorhexidine formulations on shear bond strengths of orthodontic brackets. Angle Orthod. 2009;79(2):312-6. https://doi.org/10.2319/032008-158.1 PMid:19216606 DOI: https://doi.org/10.2319/032008-158.1
Olsen ME, Bishara SE, Damon P, Jakobsen JR. Evaluation of Scotchbond Multipurpose and maleic acid as alternative methods of bonding orthodontic brackets. Am J Orthod Dentofacial Orthop. 1997;111(5):498-501. https://doi.org/10.1016/s0889-5406(97)70286-5 PMid:9155808 DOI: https://doi.org/10.1016/S0889-5406(97)70286-5
Spagnuolo G, De Vito D, Rengo S, Tatullo M. COVID-19 outbreak: An overview on dentistry. Int J Environ Res Public Health. 2020;17(6):2094. https://doi.org/10.3390/ijerph17062094 PMid:32235685 DOI: https://doi.org/10.3390/ijerph17062094
Jin YH, Cai L, Cheng ZS, Cheng H, Deng T, Fan YP, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res. 2020;7(1):1-23. https://doi.org/10.1186/s40779-020-0233-6 PMid:32029004 DOI: https://doi.org/10.1186/s40779-020-0233-6
Vinayachandran D, Balasubramanian S. Salivary diagnostics in COVID-19: Future research implications. J Dent Sci. 2020;15(3):364-6. https://doi.org/10.1016/j.jds.2020.04.006 PMid:32328218 DOI: https://doi.org/10.1016/j.jds.2020.04.006
Cavalcante-Leão BL, de Araujo CM, Basso IB, Schroder AG, Guariza-Filho O, Ravazzi GC, et al. Is there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid- 19? A systematic review. J Clin Exp Dent. 2021;13(2):e179-89. https://doi.org/10.4317/jced.57406 PMid:33575003 DOI: https://doi.org/10.4317/jced.57406
Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci. 2020;12(1):1-6. https://doi.org/10.1038/s41368-020-0075-9 PMid:32127517 DOI: https://doi.org/10.1038/s41368-020-0075-9
Shankar S, Saha A, Jamir L, Kakkar R. Protection at portal of entry (PPE) with povidone iodine for COVID-19. Int J Med Public Health. 2020;10(4):166-8. https://doi.org/10.5530/ijmedph.2020.4.36 DOI: https://doi.org/10.5530/ijmedph.2020.4.36
Sato S, Miyake M, Hazama A, Omori K. Povidone-iodine-induced cell death in cultured human epithelial HeLa cells and rat oral mucosal tissue. Drug Chem Toxicol. 2014;37(3):268-75. https://doi.org/10.3109/01480545.2013.846364 PMid:24219135 DOI: https://doi.org/10.3109/01480545.2013.846364
Kövesi G. The use of Betadine antiseptic in the treatment of oral surgical, parodontological and oral mucosal diseases. Fogor Sz. 1999;92(8):243-50. PMid:10462910
Eggers M, Koburger-Janssen T, Eickmann M, Zorn J. In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens. Infect Dis Ther. 2018;7(2):249-59. https://doi.org/10.1007/s40121-018-0200-7 PMid:29633177 DOI: https://doi.org/10.1007/s40121-018-0200-7
Hassandarvish P, Tiong V, Sazaly AB, Mohamed NA, Arumugam H, Ananthanarayanan A, et al. Povidone iodine gargle and mouthwash. Br Dent J. 2020;228(12):900. https://doi.org/10.1038/s41415-020-1794-1 PMid:32591671 DOI: https://doi.org/10.1038/s41415-020-1794-1
Donnell VB, Thomas D, Stanton R, Maillard JY, Murphy RC, Jones SA, et al. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function (Oxf). 2020;1(1):zqaa002. https://doi.org/10.1093/function/zqaa002 DOI: https://doi.org/10.1093/function/zqaa002
Caruso AA, Prete A, Lazzarino AI, Capaldi R, Grumetto L. Might hydrogen peroxide reduce the hospitalization rate and complications of SARS-CoV-2 infection? Infect Control Hosp Epidemiol. 2020;41(11):1360-1. https://doi.org/10.1017/ice.2020.170 PMid:32319881 DOI: https://doi.org/10.1017/ice.2020.170
Carrouel F, Gonçalves LS, Conte MP, Campus G, Fisher J, Fraticelli L, et al. Antiviral activity of reagents in mouth rinses against SARS-CoV-2. J Dent Res. 2021;100(2):124-32. https://doi.org/10.1177/0022034520967933 PMid:33089717 DOI: https://doi.org/10.1177/0022034520967933
Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Comparison of in vitro inactivation of SARS Cov-2 with hydrogen peroxide and povidone-iodine oral antiseptic rinses. J Prosthodont. 2020;29(7):599-603. https://doi.org/10.1111/jopr.13220 PMid:32608097 DOI: https://doi.org/10.1111/jopr.13220
Vieira-Junior WF, Ferraz LN, Giorgi MC, Ambrosano GM, Aguiar FH, Lima DA. Effect of mouth rinse treatments on bleached enamel properties, surface morphology, and tooth color. Oper Dent. 2019;44(2):178-87. https://doi.org/10.2341/17-250-l PMid:29953341 DOI: https://doi.org/10.2341/17-250-L
Sharma K, Acharya S, Verma E, Singhal D, Singla N. Efficacy of chlorhexidine, hydrogen peroxide and tulsi extract mouthwash in reducing halitosis using spectrophotometric analysis: A randomized controlled trial. J Clin Exp Dent. 2019;11(5):e457-63. https://doi.org/10.4317/jced.55523 PMid:31275519 DOI: https://doi.org/10.4317/jced.55523
Hossainian N, Slot DE, Afennich F, Van der Weijden GA. The effects of hydrogen peroxide mouthwashes on the prevention of plaque and gingival inflammation: A systematic review. Int J Dent Hyg. 2011;9(3):171-81. https://doi.org/10.1111/j.1601-5037.2010.00492.x PMid:21356027 DOI: https://doi.org/10.1111/j.1601-5037.2010.00492.x
Domingo MA, Farrales MS, Loya RM, Pura MA, Uy H. The effect of 1% povidone iodine as a pre-procedural mouthrinse in 20 patients with varying degrees of oral hygiene. J Philipp Dent Assoc. 1996;48(2):31-8. PMid:9462082
Evans A, Leishman SJ, Walsh LJ, Seow WK. Inhibitory effects of antiseptic mouthrinses on Streptococcus mutans, Streptococcus sanguinis and Lactobacillus acidophilus. Aust Dent J. 2015;60(2):247-54. https://doi.org/10.1111/adj.12312 PMid:25989101 DOI: https://doi.org/10.1111/adj.12312
Downloads
Published
How to Cite
License
Copyright (c) 2022 Alireza Ghobadi, Amin Golshah, Mohsen Safaei (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0
Funding data
-
Kermanshah University of Medical Sciences
Grant numbers 4000425