Lisinopril Can Reduce Genotoxicity of L-Asparaginase in Bone Marrow Stem Cells


  • Muthana Ibrahim Maleek Department of Biology, College of Sciences, Wasit University, Kut, Wasit, Iraq



Lisinopril, L-asparaginase, Angiotensin-converting enzyme, Genotoxicity, Stem cells, Bone marrow, Mitotic index, Micronucleus


BACKGROUND: Lisinopril is a medication used to lower blood pressure by inhibiting the angiotensin-converting enzyme (ACE). L-asparaginase is a chemotherapeutic agent used to treat acute lymphoblastic leukemia.


 AIM: To Study the effect of lisinopril on the genotoxicity of L-asparaginase (ASNase) in bone marrow stem cells.


METHODS: Albino Swiss male mice were divided into three groups. The first group was treated with lisinopril 10 mg/kg/day for 14 days. The second group mice were injected with L-asparaginase 3000 IU/kg. The last group was treated with of lisinopril for 14 days followed with an intraperitoneal injection of L-asparaginase (ASNase) at the end of the 13th day. Genotoxicity was assessed by calculating the percentage of micronucleus (MN) and mitotic index (MI).


RESULTS:   ASNase significantly increased genotoxicity by raising the %MN and lowering % MI. When Lisinopril 10 mg/kg/day was administered no significant effect was seen. However, a significant decrease in genotoxic effects was observed when mice receiving Lisinopril were injected with 3000 IU/kg ASNase as compared the group treated with ASNase alone. This effect was manifested by decreasing %MN and increasing %MI. 


 CONCLUSION:  Using lisinopril for blood hypertension treatments concurrently with the cancer therapeutic agent, L- asparaginase, decreased its genotoxicity in bone marrow stem cells.


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How to Cite

Maleek MI. Lisinopril Can Reduce Genotoxicity of L-Asparaginase in Bone Marrow Stem Cells. Open Access Maced J Med Sci [Internet]. 2022 Jun. 7 [cited 2023 Mar. 31];10(A):1033-7. Available from: