Relationship of Bactericidal Permeability Increasing Protein (BPI) Polymorphysm rs1341023, rs5743507, Tumor Necrosis Factor Alpha (TNF-α) rs361525, rs1800629 with Neonatal Sepsis

Authors

  • Afdal Afdal Department of Biomedical, Faculty of Medicine, Andalas University, Padang, Indonesia
  • Jamsari Jamsari Department of Biomedical, Faculty of Medicine, Andalas University, Padang, Indonesia
  • Yanwirasti Yanwirasti Department of Biomedical, Faculty of Medicine, Andalas University, Padang, Indonesia
  • Prambudi Rukmono Department of Child Health, University of Lampung, Hospital of Abdul Moeluk, Lampung, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9762

Keywords:

Bactericidal permeability increasing protein, Tumor necrosis factor alpha, Neonatal, Polymorphism, Sepsis

Abstract

Background: Neonatal sepsis is a problem in the field of child health because the incidence is increasing every year and often ends in death. This study aimed to investigate the relationship between TNF-α and BPI gene polymorphisms with neonatal sepsis.

Methods: PCR and sequencing examinations were performed on 60 DNA samples consisting of 30 samples of neonatal sepsis and 30 samples of non-neoptic sepsis. Furthermore, data in the form of DNA mutation tables were statistically processed by univariate, bivariate, and multivariate analysis. It is considered meaningful if p<0.05.

Result: The results showed that BPI rs1341023, rs5743507 and TNF-α rs361525, rs1800629 only BPI rs1341023 and TNF-α rs1800629 were mutated. Of the two genes, only TNF-α rs1800629 had a significant association with neonatal sepsis (p<0.05).

Conclusion: This study proved that the TNF-α rs1800629 mutation was the most important polymorphism in the occurrence of neonatal sepsis (p<0.05).

Keywords: BPI, TNF-α, Neonatal, Polymorphism, Sepsis

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Published

2022-05-12

How to Cite

1.
Afdal A, Jamsari J, Yanwirasti Y, Rukmono P. Relationship of Bactericidal Permeability Increasing Protein (BPI) Polymorphysm rs1341023, rs5743507, Tumor Necrosis Factor Alpha (TNF-α) rs361525, rs1800629 with Neonatal Sepsis. Open Access Maced J Med Sci [Internet]. 2022 May 12 [cited 2024 Mar. 29];10(A):1038-41. Available from: https://oamjms.eu/index.php/mjms/article/view/9762

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