Relationship between Febrile Seizures and Iron Deficiency Anemia in Children

Authors

  • Roua Hameed Kadhem Department of Pediatrics, Thi-Qar Medical College, Thi-Qar Governorate, Iraq
  • Ali Kadhem Tarish Pediatrician Samawa Maternity and Children Hospital, Samawa, Al-Muthana, Iraq

DOI:

https://doi.org/10.3889/oamjms.2022.9820

Keywords:

Relationship, Febrile seizures, Iron deficiency anemia, Children

Abstract

BACKGROUND: The febrile seizure is the most common type of seizures occur in children under 5 years old and the peak age is 18 months, the temperature of body 38°C or more with no neurological infection or metabolic disorder.

AIM: The aim of the present study is to found the association between iron deficiency anemia (IDA) and febrile seizure.

METHODS: A case–control study has been carried out to determine the association between febrile convulsion and IDA. One hundred and twenty-two children with febrile seizure and 130 healthy babies include in study, period of study from May 2019 to December 2019 in Bunt Al Huda teaching hospital Nasiriyah, Dhi Qar, Iraq. The sociodemographic data are age of babies, weight, and gender. Diagnosis of febrile seizure done after details history and examination. Children aged 6 months–5 years presenting with febrile convulsion for cases and controls group of same age with fever but no convulsion. Both first and recurrent episodes of FC were included for cases.

RESULTS: A case–control study of 122 children with seizures and 130 children without seizures, seizures babies have more weight than non-seizures, convulsion babies have low mean corpuscle volume than non-seizures, and seizures babies have low serum ferritin than non-seizures. There is a significant difference between mean serum ferritin of seizures and non-seizures babies, seizures babies have low serum ferritin than non-seizures.

CONCLUSION: Serum ferritin also decreases more in babies with febrile seizure so IDA is occurring more in febrile seizure, and there is an association between iron supplements deficiency and febrile seizure.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Sadeghzadeh M, Khoshnevis Asl P, Mahboubi E. Iron status and febrile seizure-acase control study in children less than 3 years. Iran J Child Neurol. 2012;6(4):27-31. PMid:24665277

Kwak BO, Kim SN, Lee R. Relationship between iron deficiency anemia and febrile seizures in children: A systematic review and meta-analysis. Seizure. 2017;52:27-34. https://doi.org/10.1016/j.seizure.2017.09.009 PMid:28957722 DOI: https://doi.org/10.1016/j.seizure.2017.09.009

Kılıç B. Clinical features and evaluation in terms of prophylaxis of patients with febrile seizures. Şişli Etfal Hastan Tip Bülteni. 2019;53(3):276-83. https://doi.org/10.14744/SEMB.2019.30633 PMid:32377096 DOI: https://doi.org/10.14744/SEMB.2019.30633

Dreier JW, Li J, Sun Y, Christensen J. Evaluation of long-term risk of epilepsy, psychiatric disorders, and mortality among children with recurrent febrile seizures: A national cohort study in Denmark. JAMA Pediatr. 2019;173(12):1164-70. https://doi.org/10.1001/jamapediatrics.2019.3343 PMid:31589251 DOI: https://doi.org/10.1001/jamapediatrics.2019.3343

Sculier C, Gaínza-Lein M, Fernández I, Loddenkemper T. Long-term outcomes of status epilepticus: A critical assessment. Epilepsia. 2018;59(Suppl 2):155-69. https://doi.org/10.1111/epi.14515 PMid:30146786 DOI: https://doi.org/10.1111/epi.14515

Paul SP, Seymour M, Flower D, Rogers E. Febrile convulsions in children. Nurs Child Young People. 2015;27(5):14-5. https://doi.org/10.7748/ncyp.27.5.14.s16 PMid:26059584 DOI: https://doi.org/10.7748/ncyp.27.5.14.s16

Patterson JL, Carapetian SA, Hageman JR, Kelley KR. Febrile seizures. Pediatr Ann. 2013;42(12):249-54. https://doi.org/10.3928/00904481-20131122-09 PMid:24295158 DOI: https://doi.org/10.3928/00904481-20131122-09

Kumari PL, Nair MK, Nair SM, Kailas L, Geeta S. Iron deficiency as a risk factor for simple febrile seizures--a case control study. Indian Pediatr. 2012;49(1):17-9. https://doi.org/10.1007/s13312-012-0008-6 PMid:21719928 DOI: https://doi.org/10.1007/s13312-012-0008-6

Kurniawan A, Lainama MS, Diarsvitri W. Mean platelet ratio, neutrophil to lymphocyte ratio, and the risk of febrile seizures in children aged 6-59 months. Open Access Maced J Med Sci. 2021;9(B):276-80. https://doi.org/10.3889/oamjms.2021.5575 DOI: https://doi.org/10.3889/oamjms.2021.5575

Zareifar S, Hosseinzadeh HR, Cohan N. Association between iron status and febrile seizures in children. Seizure. 2012;21(8):603-5. https://doi.org/10.1016/j.seizure.2012.06.010 PMid:22796045 DOI: https://doi.org/10.1016/j.seizure.2012.06.010

King D, King A. Question 2: Should children who have a febrile seizure be screened for iron deficiency? Arch Dis Child. 2014;99(10):960-3. https://doi.org/10.1136/archdischild-2014-306689 PMid:25217390 DOI: https://doi.org/10.1136/archdischild-2014-306689

Zucca FA, Segura-Aguilar J, Ferrari E, Muñoz P, Paris I, Sulzer D, et al. Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson’s disease. Prog Neurobiol. 2017;155:96-119. https://doi.org/10.1016/j.pneurobio.2015.09.012 PMid:26455458 DOI: https://doi.org/10.1016/j.pneurobio.2015.09.012

Addil F, Rehman A, Najeeb S, Imtiaz H, Khan S, Najeeb S. Iron Deficiency Anemia in children with febrile seizures. Syst Rev Pharm. 2021;12(5):301-3. https://doi.org/10.26226/morressier.57d034cfd462b8029238331f DOI: https://doi.org/10.26226/morressier.57d034cfd462b8029238331f

Jang HN, Yoon HS, Lee EH. Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea. BMC Pediatr. 2019;19(1):309. https://doi.org/10.1186/s12887-019-1675-4 PMid:31484495 DOI: https://doi.org/10.1186/s12887-019-1675-4

Peng YY, Uprichard J. Ferritin and iron studies in anaemia and chronic disease. Ann Clin Biochem. 2017;54(1):43-8. https://doi.org/10.1177/0004563216675185 PMid:27701066 DOI: https://doi.org/10.1177/0004563216675185

Cook EJ, Powell FC, Ali N, Penn-Jones C, Ochieng B, Randhawa G. Parents experiences of complementary feeding among a United Kingdom culturally diverse and deprived community. Matern Child Nutr. 2021;17(2):e13108. https://doi.org/10.1111/mcn.13108 PMid:33169518 DOI: https://doi.org/10.1111/mcn.13108

Peñas JJ. Evaluation of a child with a first unprovoked seizure. Medicina (B Aires). 2018;78(Suppl 2):6-11. PMid:30199358

Bidabadi E, Mashouf M. Association between iron deficiency anemia and first febrile convulsion: A case-control study. Seizure. 2009;18(5):347-51. https://doi.org/10.1016/j.seizure.2009.01.008 PMid:19223207 DOI: https://doi.org/10.1016/j.seizure.2009.01.008

Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64(5 Pt 2):S34-43; discussion S72-91. https://doi.org/10.1301/nr.2006.may.s34-s43 PMid:16770951 DOI: https://doi.org/10.1301/nr.2006.may.S34-S43

Ghasemi F, Valizadeh F, Taee N, Jundishapur A, Ahvaz Jundishapur VF. Iron-deficiency Anemia in Children with Febrile Seizure: A case-control study. Iran J Child Neurol. 2014;8(2):38-44. PMid:24949050

Kumar BT, Thandapani K, Babu SV. Iron deficiency anemia as a risk factor for simple febrile seizures in pediatric patients. Int J Contemp Pediatr. 2019;6(4):1414-20. https://doi.org/10.18203/2349-3291.ijcp20192126 DOI: https://doi.org/10.18203/2349-3291.ijcp20192126

Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C, et al. The association between iron deficiency and febrile seizures in childhood. Clin Pediatr (Phila). 2009;48(4):420-6. https://doi.org/10.1177/0009922809331800 PMid:19229063 DOI: https://doi.org/10.1177/0009922809331800

Papageorgiou V, Vargiami E, Kontopoulos E, Kardaras P, Economou M, Athanassiou-Mataxa M, et al. Association between iron deficiency and febrile seizures. Eur J Paediatr Neurol. 2015;19(5):591-6. https://doi.org/10.1016/j.ejpn.2015.05.009 PMid:19229063 DOI: https://doi.org/10.1016/j.ejpn.2015.05.009

Karimi P, Badfar G, Soleymani A, Khorshidi A, Tardeh Z. Association of iron deficiency anemia and febrile seizure in Asia: A systematic review and meta-analysis. Iran J Neonatol. 2018;9(1):42-52. https://doi.org/10.22038/ijn.2018.22323.1264 DOI: https://doi.org/10.1515/ijamh-2019-0083

Habibian N, Alipour A, Rezaianzadeh A. Association between iron deficiency Anemia and febrile convulsion in 3- to 60-month- Old children: A systematic review and Meta-analysis. Iran J Med Sci. 2014;39(6):496-505. PMid:25429171

Christensen KJ, Dreier JW, Skotte L, Feenstra B, Grove J, Børglum A, et al. Birth characteristics and risk of febrile seizures. Acta Neurol Scand. 2021;144(1):51-7. https://doi.org/10.1111/ane.13420 PMid:33822360 DOI: https://doi.org/10.1111/ane.13420

Lee SH, Byeon JH, Kim GH, Eun BL, Eun SH. Epilepsy in children with a history of febrile seizures. Korean J Pediatr. 2016;59(2):74-9. https://doi.org/10.3345/kjp.2016.59.2.74 PMid:26958066 DOI: https://doi.org/10.3345/kjp.2016.59.2.74

Ueda H, Tajiri H, Kimura S, Etani Y, Hosoi G, Maruyama T, et al. Clinical characteristics of seizures associated with viral gastroenteritis in children. Epilepsy Res. 2015;109(1):146-54. https://doi.org/10.1016/j.eplepsyres.2014.10.021 DOI: https://doi.org/10.1016/j.eplepsyres.2014.10.021

Downloads

Published

2022-06-22

How to Cite

1.
Kadhem RH, Tarish AK. Relationship between Febrile Seizures and Iron Deficiency Anemia in Children. Open Access Maced J Med Sci [Internet]. 2022 Jun. 22 [cited 2024 Apr. 24];10(B):1827-31. Available from: https://oamjms.eu/index.php/mjms/article/view/9820

Similar Articles

You may also start an advanced similarity search for this article.