Determinant Factors of Neonatal Mortality in Preeclampsia Mother

Authors

  • Hirfa Turrahmi Doctoral Student, Faculty of Medicine, University of Padjadjaran, Bandung, Indonesia; Department of Obstetric, Faculty of Medicine and Health, University of Muhammadiyah Jakarta, Jakarta, Indonesia
  • Hadyana Sukandar Department of Public Health Sciences, University of Padjadjaran, Bandung, Indonesia
  • Hadi Susiarno Department of Obstetrics and Gynecology, University of Padjadjaran, Bandung, Indonesia
  • Rudi Supriyadi Department of Internal Medicine, University of Padjadjaran, Bandung, Indonesia
  • Fatimah Fatimah Department of Obstetric, Faculty of Medicine and Health, University of Muhammadiyah Jakarta, Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9825

Keywords:

Bacteriuria, Infant mortality, Parity, Preeclampsia, Proteinuria

Abstract

BACKGROUND: Preeclampsia (PE) is a specific multisystemic disorder in pregnancy and a significant cause of maternal and fetal death. The percentage of infant mortality due to preeclampsia is greater than maternal mortality. Infant mortality occurs due to several risk factors in mothers with preeclampsia.

AIM: This study aims to analyze the determinants of infant mortality in mothers with preeclampsia.

METHODS: An observational analytic study with a cross-sectional design was undertaken at the Department of Obstetrics and Gynecology at the Koja Hospital, North Jakarta, from June to September 2021. Three hundred and twenty-eight research subjects met the research criteria. Bivariate analysis using Chi-square and Fisher’s exact test and multivariate analysis using logistic regression test. All data analyzed with SPPS version 22.0

RESULTS: In this study, there was no relationship between maternal age (p = 0.842), body mass index (p = 0.768), education (p = 0.345), occupation (p = 1,000), mode of delivery (p = 0.753), anemia (p = 0.707), leukocytosis (p = 0.772), hypoalbuminemia (p = 0.688), and bacteriuria (p = 0.245) with neonatal mortality in mothers with preeclampsia. In addition, the results showed that the factors that contributed to neonatal mortality in mothers with preeclampsia were parity (PR (CI 95%) =15.279 (2.304–101.301); p = 0.005) and proteinuria (PR (CI 95%) =9.649 (1.123–82.875); p = 0.039).

CONCLUSION: It can be concluded that parity and proteinuria are determinants of neonatal mortality in mothers with preeclampsia.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Data and Information Center. Indonesian Health Profile 2019. Indonesia: Indonesian Ministry of Health Information Center; 2020. p. 98.

Tsabitah K, Wicaksono B, Samsriyaningsih H. Severe preeclampsia leads to higher prevalence of mortality and morbidity affecting maternal outcomes in single tertiary hospital. Majalah Obstet Ginekol. 2020;28(3):99-103. https://doi.org/10.20473/mog.V28I32020.99-103 DOI: https://doi.org/10.20473/mog.V28I32020.99-103

Fox R, Kitt J, Leeson P, Aye CY, Lewandowski AJ. Preeclampsia: Risk factors, diagnosis, management and the cardiovascular impact on the offspring. J Clin Med. 2019;8(10):1625. https://doi.org/10.3390/jcm8101625 PMid:31590294 DOI: https://doi.org/10.3390/jcm8101625

Duffy JM, Cairns AE, Richards-Doran D, Van’t Hooft J, Gale C, Brown M, et al. A core outcome set for pre-eclampsia research: An international consensus development study. BJOG. 2020;127(12):1516-26. https://doi.org/10.1111 / 1471-0528.16319 PMid:32416644 DOI: https://doi.org/10.1111/1471-0528.16319

Tsigas EZ. The preeclampsia foundation: The voice and views of the patient and her family. Am J Obstet Gynecol. 2021;226(2S):S1254-64.e1. https://doi.org/10.1016/j.ajog.2020.10.053 PMid:34479720 DOI: https://doi.org/10.1016/j.ajog.2020.10.053

Tlaye KG, Endalfer ML, Kassaw MW, Gebremedhin MM, Aynalem YA. Preeclampsia management modalities and perinatal death: A retrospective study in Woldia general hospital. BMC Pregnancy Childbirth. 2020;20(1):205. https://doi.org/10.1186/s12884-020-02909-9 PMid:32272909 DOI: https://doi.org/10.1186/s12884-020-02909-9

Hodgins S. Pre-eclampsia as underlying cause for perinatal deaths: Time for action. Glob Health Sci Pract. 2015;3(4):525-7. https://doi.org/10.9745/GHSP-D-15-00350 PMid:26681699 DOI: https://doi.org/10.9745/GHSP-D-15-00350

Morikawa M, Mayama M, Noshiro K, Saito Y, Nakagawa-Akabane K, Umazume T, et al. Earlier onset of proteinuria or hypertension is a predictor of progression from gestational proteinuria to preeclampsia. Sci Rep. 2021;11:12708. https://doi.org/10.1038/s41598-021-92189-w DOI: https://doi.org/10.1038/s41598-021-92189-w

Al Rubaie ZT, Hudson HM, Jenkins G, Mahmoud I, Ray JG, Lord SJ, et al. Prediction of pre-eclampsia in nulliparous women using routinely collected maternal characteristics: A model development and validation study. BMC Pregnancy Childbirth. 2020;20(1):23. https://doi.org/10.1186/s12884-019-2712-x PMid:31906891 DOI: https://doi.org/10.1186/s12884-019-2712-x

Gathiram P, Moodley J. Pre-eclampsia: Its pathogenesis and pathophysiology. Cardiovasc J Afr. 2016;27(2):71-8. https://doi.org/10.5830/CVJA-2016-009 PMid:27213853 DOI: https://doi.org/10.5830/CVJA-2016-009

Lokki AI, Heikkinen-Eloranta JK, Laivuori H. The immunogenitic conundrum of preeclampsia. Front Immunol. 2018;9:2630. https://doi.org/10.3389/fimmu.2018.02630 PMid:30483272 DOI: https://doi.org/10.3389/fimmu.2018.02630

Phipps E, Prasanna D, Brima W, Jim B. Preeclampsia: Updates in pathogenesis, definitions and guidelines. Clin J Am Soc Nephrol. 2016;11(6):1102-13. https://doi.org/10.2215/CJN.12081115 PMid:27094609 DOI: https://doi.org/10.2215/CJN.12081115

Xu X, Wang Y, Xu H, Kang Y, Zhu Q. Association between proteinuria and maternal and neonatal outcomes in preeclampsia pregnancy: A retrospective observational study. J Int Med Res. 2020;48(4):1184-90. https://doi.org/10.1177 / 0300060520908114 PMid:32339047 DOI: https://doi.org/10.1177/0300060520908114

Yusrizal F, Koeshardani F, Agustina H, Ali Z, Junaidi AR. Maternal death cause by antepartum eclampsia, with HELLP syndrome and AKI stage III: A preventable recurrent death. Biosci Med. 2021;5(1):1049-53. https://doi.org/10.32539/bsm.v5i1.372 DOI: https://doi.org/10.32539/bsm.v5i11.372

Downloads

Published

2022-06-01

How to Cite

1.
Turrahmi H, Sukandar H, Susiarno H, Supriyadi R, Fatimah F. Determinant Factors of Neonatal Mortality in Preeclampsia Mother. Open Access Maced J Med Sci [Internet]. 2022 Jun. 1 [cited 2024 Apr. 17];10(B):1543-6. Available from: https://oamjms.eu/index.php/mjms/article/view/9825

Issue

Section

Gynecology and Obstetrics

Categories