Diagnostic Value of Nuclear Receptor Subfamily 4 Group A Member 3 in Salivary Gland Carcinomas

Asmaa S. Algharyani; Marwa M. Maghrabi; Samah K. Ezzat; Marwa M. Shakweer; Doaa Esmaeil

doi:10.3889/oamjms.2022.9831

Authors

Asmaa S. Algharyani Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tripoli University, Tripoli, Libya
Marwa M. Maghrabi Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tripoli University, Tripoli, Libya
Samah K. Ezzat Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
Marwa M. Shakweer Department of General Pathology, Ain Shams University, Cairo, Egypt; Department of Pathology, Badr University in Cairo (BUC), Badr City, Egypt
Doaa Esmaeil Department of Oral Pathology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt https://orcid.org/0000-0001-9054-8333

DOI:

https://doi.org/10.3889/oamjms.2022.9831

Keywords:

Salivary gland carcinomas, Nuclear receptor subfamily 4 Group A member 3, Immunohistochemistry, Acinic cell carcinoma

Abstract

Salivary gland carcinomas are diagnostically challenging lesions in heterogeneous groups. However, recently described genomic alterations may be helpful and have future therapeutic implications. The molecular investigation is becoming useful tool to help diagnosis and provide prognostic information. Diagnosis of acinic cell carcinoma (AcCC) is challenging due to its rarity and similarity with other SGCs or normal acinar cells.

Herein, the diagnostic performance of transcription factor nuclear receptor subfamily 4 group A member3 (NR4A3) was analysed immunohistochemically. This study was done on 68 cases of SCCs, including 32 of AcCC, 14 of adenoid cystic carcinoma (AdCC), 8 of mucoepidermoid carcinoma (MEC), 7 of epithelial myoepithelial carcinoma (EMC), 4 of salivary duct carcinoma (SDC), and only one case from each of carcinoma ex pleomorphic adenoma (CXPA), polymorphous adenocarcinoma (PAC) and secretory carcinoma (SC) for detecting NR4A3.

All stained samples of AcCC (100%) responded positively to the NR4A3 antibody. However, only one case of AdCC and MEC demonstrated NR4A3 immunostaining in less than 10% of cells. On the other hand, the different types of SGCs, including EMC, SDC, CXPA, PAC, and SC, revealed negative expressions. Therefore, we can conclude that NR4A3 can be used as a potential marker for AcCC rather than other SGCs.

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