Relationship Between Phylogenetic of Apium and Foeniculum Plants from Central Java, Indonesia, and Their Secondary Metabolites Potency against COVID-19 Protease

Hermin Pancasakti Kusumaningrum; Rejeki Siti Ferniah; Siti Nur Jannah; Mufida Budi Kurniawati; Anis Afifah; Yoshua Mario Sumbodo; Salma Seftia Hanif; Tia Erfianti; Yuriza Eshananda

doi:10.3889/oamjms.2022.9852

Authors

Hermin Pancasakti Kusumaningrum Biotechnology Study Program, Department of Biology, Faculty of Science and Mathematics, Diponegoro University,Semarang, Indonesia
Rejeki Siti Ferniah Biotechnology Study Program
Siti Nur Jannah Biotechnology Study Program
Mufida Budi Kurniawati Biotechnology Study Program
Anis Afifah Biotechnology Study Program
Yoshua Mario Sumbodo Biotechnology Study Program
Salma Seftia Hanif Biotechnology Study Program
Tia Erfianti Post Graduate Study Program
Yuriza Eshananda Biology Study Program

DOI:

https://doi.org/10.3889/oamjms.2022.9852

Keywords:

Apium, Foeniculum, Phylogenetic, COVID-19 proteases

Abstract

BACKGROUND: The emergence of COVID-19 in the late of 2019 resulted in the massive screening of drugs, including natural products, to support the current vaccines. Apium and Foeniculum vegetables are members of the Apiaceae family that potentially used to be natural immunosuppressant.

AIM: The purpose of this research is to analyze the phylogenetic position between these two plants as well as find out their secondary metabolites potency against COVID-19 main protease (Mpro) and the papain-like protease (PLpro).

METHODS: The phylogenetic analysis of Apium and Foeniculum from Indonesia was carried out based on internal transcribed spacer (ITS) region and the bioactive virtual screening assay was completed through AutoDock Vina software.

CONCLUSION: Overall, Apium and Foeniculum have close relationships among the members of Apiaceae after maximum likelihood analysis. Furthermore, it also has 70 similar bioactive compounds that some of these potentially inhibit both of COVID-19 proteases.

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