Quality of Life among Children with Osteogenesis Imperfecta Receiving Bisphosphonate Therapy Before and during the 1st Year of the COVID-19 Pandemic in Dr. Soetomo Hospital, Surabaya

Rahma Ira Mustikasari; Nur  Rochmah; Muhammad  Faizi; Irwanto Irwanto

doi:10.3889/oamjms.2023.9885

Authors

Rahma Ira Mustikasari Department of Child Health, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia
Nur Rochmah Department of Child Health, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia
Muhammad Faizi Department of Child Health, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia
Irwanto Irwanto Department of Child Health, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2023.9885

Keywords:

Osteogenesis imperfecta, PedsQL, COVID-19 pandemic

Abstract

BACKGROUND: Osteogenesis imperfecta (OI) is a chronic illness caused by a connective tissue disorder that may lead to frequent fractures. Therefore, it may influence the quality of life (QoL). The study on QoL among children with OI during the coronavirus disease-19 (COVID-19) pandemic is still limited.

AIM: This study aims to evaluate QoL before and during the COVID-19 pandemic in children with OI.

METHODS: This cross-sectional study took place in the Pediatric Endocrinology Outpatient Clinic at Dr. Soetomo General Hospital, Surabaya, in 2020. The pre-pandemic data came from 2019 medical records. The questionnaire used was the Pediatric Quality of Life Inventory (PedsQL) 4.0 generic core. Twenty-two patients joined the study; 11/22 of them were girls.

RESULTS: The mean age, fracture, and frequency of zoledronic acid treatment were 6.9 years old, 2.5×/year, and 7.1×/year, respectively. The PedsQL comparisons before and during the first year of the COVID-19 pandemic in each dimension were: Physical (49.57 vs. 42.76; p = 0.001), emotional (63.41 vs. 54.54; p = 0.001), social (58.86 vs. 53.86; p = 0.015), and school functioning (66.13 vs. 56.74; p = 0.001), respectively. The most affected dimension was school functioning (mean difference (minimum–maximum): (−9.39) (−14.28–[−4.49]), whereas the physical, emotional, and social functioning were 6.81 (3.43–10.19), 8.86 (5.06–12.67), and −5.00 (−8.93–(−1.07)), respectively.

CONCLUSION: The QoL in children with OI during the COVID-19 pandemic was worst, especially in the school functioning dimension. Online consultation options may be beneficial to improving the QoL.

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