Propolis Mitigates Rifampicin/Isoniazid-induced Lipid-redox and Metabolic Profile in an Experimental Animal Model of Oxidative Stress

Authors

  • Ahmed Abdulsallam Alkhansaa Teaching hospital, Mosul, Iraq
  • Imad A. Thanoon College of Medicine
  • Rwqaya S. Dawood College of Medicine, University of Mosul, Mosul, Iraq
  • Abdulrahman I. Abduljabbar Graduated Physician, University of Mosul, Mosul, Iraq

DOI:

https://doi.org/10.3889/oamjms.2022.9918

Keywords:

Isoniazid, Rifampicin, Propolis, FBS, TAS, MDA, Lipid

Abstract

Objective: Adverse drug reactions are the most common cause of drug withdrawal in chronic treatment settings. Tuberculosis (TB) has been considered a recurrent and relapsing disease that needs long-term therapy. Most patients suffer from the adverse effects of TB therapy. Hence, various remedies were used to tackle these adverse effects including antioxidant vitamins, herbal remedies, and others. Aims: The present intervention study aims to investigate the role of propolis in protecting the animal model against oxidant/antioxidant induced by TB therapy together with the propolis role in modulation of metabolic profile as part of lipid peroxidation context. Methods: Serum was collected from rats exposed to rifampicin/isoniazid with or without propolis therapy alongside the control placebo group for comparison. Results: The results have shown a significant (p<0.05) reduction of malondialdehyde and significant (p<0.05) elevation of total antioxidant status. Lipid profile positively improved indicated by significantly reduced total cholesterol, triglyceride, and elevated high-density lipoprotein. Conclusion:  our study confirmed that propolis provides protection against redox and metabolic derangement induced by rifampicin/isoniazid medications which are in current TB therapy, therefore, we do advise the use of propolis as an adjunct therapy for patients on such medications.

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Published

2022-05-26

How to Cite

1.
Abdulsallam A, Thanoon IA, Dawood RS, Abduljabbar AI. Propolis Mitigates Rifampicin/Isoniazid-induced Lipid-redox and Metabolic Profile in an Experimental Animal Model of Oxidative Stress. Open Access Maced J Med Sci [Internet]. 2022 May 26 [cited 2024 Apr. 18];10(A):965-70. Available from: https://oamjms.eu/index.php/mjms/article/view/9918