TORCH, Anti-cardiolepin, and Anti-phospholipids in Women with Repeated Miscarriage in Mosul City
DOI:
https://doi.org/10.3889/oamjms.2022.9921Keywords:
Anticardiolepin, Antiphospholipids, Abortion, Miscarriage, TORCH, Viral infectionAbstract
Abstract
Background and Objective: The present study aimed to identify a connection between common viral infections and women who had repeatedly miscarriages.
Material and Methods: This study is a retrospective study which has been carried out on 2010 records in Mosul city/Iraq, and the patients were all women of child-bearing age (20-35 years old). All of the women had suffered from an abortion at least once before. The target viruses in charge for this study include; Toxoplasma gundi, Cytomegalovirus, Rubella virus, and Herpes virus.
Results and Conclusion: The analysis is based on the detection of the anti-bodies which confirmed a negative correlation between antibodies level and active viral infection, together with no clear association between the presence of active infectious status and miscarriage. Additionally, only few positive cases for each individual patient were positive for viral infection. Hence, the outcome confirmed no clear association between presence of infectious agent and repeated miscarriage. Nonetheless, rubella and cytomegalovirus have shown the highest contribution in this regard.
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Stirrat GM. Recurrent miscarriage. Lancet. 1990;336(8716):673-5. https://doi.org/10.1016/0140-6736(90)92159-f PMid:1975862
Maconochie N, Doyle P, Prior S, Simmons R. Risk factors for first trimester miscarriage--results from a UK-population-based case-control study. BJOG. 2007;114(2):170-86. https://doi.org/10.1111/j.1471-0528.2006.01193.x PMid:17305901
Broen AN, Moum T, Bødtker AS, Ekeberg Ø. The course of mental health after miscarriage and induced abortion: A longitudinal, five-year follow-up study. BMC Med. 2005;3:18. https://doi.org/10.1186/1741-7015-3-18 PMid:16343341
Jackman C, McGee HM, Turner M. The experience and psychological impact of early miscarriage. Irish J Psychol. 1991;12(2):108-20. https://doi.org/10.1080/03033910.1991.105 57831
Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SE, Horne AW. The role of infection in miscarriage. Hum Reprod Update. 2016;22(1):116-33. https://doi.org/10.1093/humupd/dmv041 PMid:26386469
Kapranos NC, Kotronias DC. Detection of herpes simplex virus in first trimester pregnancy loss using molecular techniques. In Vivo. 2009;23(5):839-42. PMid:19779121
Kim ID, Chang HS, Hwang KJ. Herpes simplex virus 2 infection rate and necessity of screening during pregnancy: A clinical and seroepidemiologic study. Yonsei Med J. 2012;53(2):401-7. https://doi.org/10.3349/ymj.2012.53.2.401 PMid:22318830
Hermonat PL, Han L, Wendel PJ, Quirk JG, Stern S, Lowery CL, et al. Human papillomavirus is more prevalent in first trimester spontaneously aborted products of conception compared to elective specimens. Virus Genes. 1997;14(1):13-7. https://doi.org/10.1023/a:1007975005433 PMid:9208451
Garolla A, Pizzol D, Foresta C. The role of human papillomavirus on sperm function. Curr Opin Obstet Gynecol. 2011;23(4):232-7. https://doi.org/10.1097/gco.0b013e328348a3a4 PMid:21666465
Sayyadi-Dehno Z, Khorrami SM, Ghavami N, Ghotbi-Zadeh F, Khushideh M, Hosseini M, et al. Molecular detection of adeno-associated virus DNA in cases of spontaneous and therapeutic abortion. Fetal Pediatr Pathol. 2019;38(3):206-14. https://doi.org/10.1080/15513815.2019.1576817 PMid:30821558
Banatvala JE, Brown DW. Rubella. Lancet. 2004;363(9415):1127-37. https://doi.org/10.1016/s0140-6736(04)15897-2 PMid:15064032
Metcalf CJ, Munayco CV, Chowell G, Grenfell BT, Bjørnstad ON. Rubella metapopulation dynamics and importance of spatial coupling to the risk of congenital rubella syndrome in Peru. J R Soc Interface. 2011;8(56):369-76. https://doi.org/10.1098/rsif.2010.0320 PMid:20659931
Muscat M, Shefer A, Ben Mamou M, Spataru R, Jankovic D, Deshevoy S, et al. The state of measles and rubella in the WHO European region, 2013. Clin Microbiol Infect. 2014;20(S5):12-8. https://doi.org/10.1111/1469-0691.12584 PMid:24520948
Wiss K, Brown TJ. Parvovirus B19. Mucocutaneous Manifestations Viral Disease. New York: Marcel Dekker; 2002. p. 295-306. https://doi.org/10.1201/9780203910733.ch13
Halsby K, Guy E, Said B, Francis J, O’Connor C, Kirkbride H, et al. Enhanced surveillance for toxoplasmosis in England and Wales, 2008-2012. Epidemiol Infect. 2014;142(8):1653-60. https://doi.org/10.1017/s095026881300246x PMid:24093517
Al-Memar M, Bobdiwala S, Fourie H, Mannino R, Lee YS, Smith A, et al. The association between vaginal bacterial composition and miscarriage: A nested case-control study. BJOG. 2020;127(2):264-74. https://doi.org/10.1111/1471-0528.15972 PMid:31573753
Vinatier D, Dufour P, Cosson M, Houpeau JL. Antiphospholipid syndrome and recurrent miscarriages. Eur J Obstet Gynecol Reprod Biol. 2001;96(1):37-50. https://doi.org/10.1016/s0301-2115(00)00404-8 PMid:11311759
Naru T, Khan RS, Ali R. Pregnancy outcome in women with antiphospholipid syndrome on low-dose aspirin and heparin: A retrospective study. East Mediterr Health J. 2010;16(3):308-12. https://doi.org/10.26719/2010.16.3.308 PMid:20795446
Sater MS, Finan RR, Abu-Hijleh FM, Abu-Hijleh TM, Almawi WY. Anti-phosphatidylserine, anti-cardiolipin, anti-β2 glycoprotein I and anti-prothrombin antibodies in recurrent miscarriage at 8-12 gestational weeks. Eur J Obstet Gynecol Reprod Biol. 2012;163(2):170-4. https://doi.org/10.1016/j.ejogrb.2012.04.001 PMid:22555404
Da Silva Santos T, Ieque AL, De Carvalho HC, Sell AM, Lonardoni MV, Demarchi IG, et al. Antiphospholipid syndrome and recurrent miscarriage: A systematic review and meta-analysis. J Reprod Immunol. 2017;123:78-87. https://doi.org/10.1016/j.jri.2017.09.007 PMid:28985591
Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet. 2001;357(9267):1513-8. https://doi.org/10.1016/s0140-6736(00)04638-9 PMid:11377626
Hadar E, Yogev Y, Melamed N, Chen R, Amir J, Pardo J. Periconceptional cytomegalovirus infection: Pregnancy outcome and rate of vertical transmission. Prenat Diagn. 2010;30(12-13):1213-6. https://doi.org/10.1002/pd.2654 PMid:21072785
Saraswathy TS, Az-Ulhusna A, Asshikin RN, Suriani S, Zainah S. Seroprevalence of cytomegalovirus infection in pregnant women and associated role in obstetric complications: A preliminary study. Southeast Asian J Trop Med Public Health. 2011;42(2):320-2. PMid:21710852
Vado-Solís IA, Suárez-Solís V, Jiménez-Delgadillo B, Zavala- Velázquez JE, Segura-Correa JC. Toxoplasma gondii presence in women with spontaneous abortion in Yucatan, Mexico. J Parasitol. 2013;99(2):383-5. https://doi.org/10.1645/ge-3189.1 PMid:22924922
Alvarado-Esquivel C, Pacheco-Vega SJ, Hernández-Tinoco J, Centeno-Tinoco MM, Beristain-García I, Sánchez-Anguiano LF, et al. Miscarriage history and Toxoplasma gondii infection: A cross-sectional study in women in Durango City, Mexico. Eur J Microbiol Immunol (Bp). 2014;4(2):117-22. https://doi.org/10.1556/eujmi.4.2014.2.4 PMid:24883197
Galvan-Ramirez MD, Troyo R, Roman S, Calvillo-Sanchez C, Bernal-Redondo R. A systematic review and meta-analysis of Toxoplasma gondii infection among the Mexican population. Parasit Vectors. 2012;5(1):271. https://doi.org/10.1186/1756-3305-5-271
Klaren VN, Kijlstra A. Toxoplasmosis, an overview with emphasis on ocular involvement. Ocul Immunol Inflamm. 2002;10(1):1-26. https://doi.org/10.1076/ocii.10.1.1.10330 PMid:12461700
Entrican G. Immune regulation during pregnancy and host-pathogen interactions in infectious abortion. J Comp Pathol. 2002;126(2-3):79-94. https://doi.org/10.1053/jcpa.2001.0539 PMid:11944996
Chaouat G, Ledée-Bataille N, Dubanchet S, Zourbas S, Sandra O, Martal J. Th1/Th2 paradigm in pregnancy: Paradigm lost? Cytokines in pregnancy/early abortion: Reexamining the Th1/Th2 paradigm. Int Arch Allergy Immunol. 2004;134(2):93-119. https://doi.org/10.1159/000074300 PMid:15153791
Guleria I, Pollard JW. The trophoblast is a component of the innate immune system during pregnancy. Nat Med. 2000;6(5):589-93. https://doi.org/10.1038/75074 PMid:10802718
Moffett-King A. Natural killer cells and pregnancy. Nat Rev Immunol. 2002;2(9):656-63. https://doi.org/10.1038/nri886 PMid:12209134
Gardner L, Moffett A. Dendritic cells in the human decidua. Biol Reprod. 2003;69(4):1438-46. https://doi.org/10.1095/biolreprod.103.017574 PMid:12826583
Thaxton JE, Sharma S. Interleukin-10: A multi-faceted agent of pregnancy. Am J Reprod Immunol. 2010;63(6):482-91. https://doi.org/10.1111/j.1600-0897.2010.00810.x PMid:20163400
Jerzak M, Bischof P. Apoptosis in the first trimester human placenta: The role in maintaining immune privilege at the maternal-foetal interface and in the trophoblast remodelling. Eur J Obstet Gynecol Reprod Biol. 2002;100(2):138-42. https://doi.org/10.1016/s0301-2115(01)00431-6 PMid:11750952
Joswig A, Gabriel HD, Kibschull M, Winterhager E. Apoptosis in uterine epithelium and decidua in response to implantation: Evidence for two different pathways. Reprod Biol Endocrinol. 2003;1:44. https://doi.org/10.1186/1477-7827-1-44 PMid:12801416
Ball E, Bulmer JN, Ayis S, Lyall F, Robson SC. Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion. J Pathol. 2006;208(4):535-42. https://doi.org/10.1002/path.1927 PMid:16402350
Agbor-Enoh ST, Achur RN, Valiyaveettil M, Leke R, Taylor DW, Gowda DC. Chondroitin sulfate proteoglycan expression and binding of Plasmodium falciparum-infected erythrocytes in the human placenta during pregnancy. Infect Immun. 2003;71(5):2455-61. https://doi.org/10.1128/iai.71.5.2455-2461.2003 PMid:12704116
Moreno-Pérez DA, Ruíz JA, Patarroyo MA. Reticulocytes: Plasmodium vivax target cells. Biol Cell. 2013;105(6):251-60. https://doi.org/10.1111/boc.201200093 PMid:23458497
Vazquez-Boland JA, Kuhn M, Berche P, Chakraborty T, Dominguez-Bernal G, Goebel W, et al. Listeria pathogenesis and molecular virulence determinants. Clin Microbiol Rev. 2001;14(3):584-640. https://doi.org/10.1128/cmr.14.3.584-640.2001 PMid:11432815
Lecuit M, Nelson DM, Smith SD, Khun H, Huerre M, Vacher- Lavenu MC, et al. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: Role of internalin interaction with trophoblast E-cadherin. Proc Natl Acad Sci U S A. 2004;101(16):6152-7. https://doi.org/10.1073/pnas.0401434101 PMid:15073336
Disson O, Grayo S, Huillet E, Nikitas G, Langa-Vives F, Dussurget O, et al. Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis. Nature. 2008;455(7216):1114-8. https://doi.org/10.1038/nature07303 PMid:18806773
Coste J, Job-spira N, Fernandez H. Risk factors for spontaneous abortion: A case-control study in france. Hum Reprod. 1991;6(9):1332-7. https://doi.org/10.1093/oxfordjournals.humrep.a137535 PMid:1752937
Nielsen GL, Sørensen HT, Larsen H, Pedersen L. Risk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: Population based observational study and case-control study. Br Med J. 2001;322(7281):266-70. https://doi.org/10.1136/bmj.322.7281.266 PMid:11157526
Sopori M. Effects of cigarette smoke on the immune system. Nat Rev Immunol. 2002;2(5):372-7. https://doi.org/10.1038/nri803 PMid:12033743
Lashen H, Fear K, Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: Matched case-control study. Hum Reprod. 2004;19(7):1644-6. https://doi.org/10.1093/humrep/deh277 PMid:15142995
Kashanian M, Akbarian AR, Baradaran H, Shabandoust SH. Pregnancy outcome following a previous spontaneous abortion (miscarriage). Gynecol Obstet Invest. 2006;61(3):167-70. https://doi.org/10.1159/000091074 PMid:16428886
Allanson B, Jennings B, Jacques A, Charles AK, Keil AD, Dickinson JE. Infection and fetal loss in the mid-second trimester of pregnancy. Aust N Z J Obstet Gynaecol. 2010;50(3):221-5. https://doi.org/10.1111/j.1479-828x.2010.01148.x PMid:20618237
Benedetto C, Tibaldi C, Marozio L, Marini S, Masuelli G, Pelissetto S, et al. Cervicovaginal infections during pregnancy: Epidemiological and microbiological aspects. J Matern Neonatal Med. 2004;16(Suppl 2):9-12. https://doi.org/10.1080/14767050410001727107 PMid:15590426
Goldenberg RL, Thompson C. The infectious origins of stillbirth. Am J Obstet Gynecol. 2003;189(3):861-73. https://doi.org/10.1067/s0002-9378(03)00470-8 PMid:14526331
Garland SM, Ní Chuileannáin F, Satzke C, Robins-Browne R. Mechanisms, organisms and markers of infection in pregnancy. J Reprod Immunol. 2002;57(1-2):169-83. https://doi.org/10.1016/s0165-0378(02)00018-9 PMid:12385841
Srinivas SK, Ma Y, Sammel MD, Chou D, McGrath C, Parry S, et al. Placental inflammation and viral infection are implicated in second trimester pregnancy loss. Am J Obstet Gynecol. 2006;195(3):797-802. https://doi.org/10.1016/j.ajog.2006.05.049 PMid:16949414
Baud D, Regan L, Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr Opin Infect Dis. 2008;21(1):70-6. https://doi.org/10.1097/qco.0b013e3282f3e6a5 PMid:18192789
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Copyright (c) 2022 Karam A. Aldabbagh, Mohammed KJ. Alnori , Khalid W. Almola (Author)

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