The Biological Role of Advanced Glycation End Products in the Development and Progression of Colorectal Cancer

Muthear Dawood; Zaid Muwafaq Younus; Mohammed Alnori; Sameer Mahmood

doi:10.3889/oamjms.2022.9926

Authors

Muthear Dawood College of Pharmacy, University of Mosul, Mosul, Iraq
Zaid Muwafaq Younus College of Pharmacy, University of Mosul, Mosul, Iraq
Mohammed Alnori College of Pharmacy, University of Mosul, Mosul, Iraq
Sameer Mahmood College of Pharmacy, University of Mosul, Mosul, Iraq

DOI:

https://doi.org/10.3889/oamjms.2022.9926

Keywords:

Glycation, Cancer, Colon, Oxidative stress

Abstract

“Colorectal cancer” (CRC) is one of the most prevalent cancers, posing a scientific challenge and serving as a model for investigating the molecular pathways underlying its development. “Advanced glycation end products” (AGEs) have drawn interest in this context. The buildup of these diverse, chemically complex groups, which are formed by a “non-enzymatic interaction” between reducing sugar and a range of macromolecules, significantly increases “inflammation and oxidative stress” in the body, which has long been associated to cancer formation. The traditional pathways that promote AGE formation, as well as the significance of AGEs’ interaction with the receptor for “advanced glycation end products” (RAGE) and other means involved in CRC initiation and progression, are discussed in this review.

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