Interleukin-1β, 27 Level in Stimulated and Non-stimulated PCOS Infertile Women (Cross-Sectional Study)

Manal Taha Al-Obaidi; Enas Thamer; Qais Ahmed Ibraheem

doi:10.3889/oamjms.2022.9973

Authors

Manal Taha Al-Obaidi Department of Obstetrics and Gynecology,, High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq
Enas Thamer Department of Obstetrics and Gynecology, College of Medicine, Al-Nahrain University, Baghdad, Iraq
Qais Ahmed Ibraheem Department of Basic Science, Faculty of Agricultural Engineering Science, Baghdad University, Baghdad, Iraq

DOI:

https://doi.org/10.3889/oamjms.2022.9973

Keywords:

Polycystic ovary syndrome, Interleukin-27, Interleukin-1ß, Pro-inflammatory cytokine, Infertility

Abstract

Background: Polycystic ovary syndrome (PCOS) stands for highly prevalent female endocrine pathology. Females suffering from PCOS have a significantly higher number of inflammatory markers. The IL-1 family members enormously affect the innate immune system. Objectives: Study the changes in the levels of Interleukin- 1ß and Interleukin- 27 in the stimulated and non-stimulated cycle (by gonadotrophin) in polycystic ovarian syndrome women. Methods: Fifty-eight infertile women with polycystic ovary syndrome (PCOS) have been included in this research article. Twenty-nine of them did not undergo ovulation induction (OI) protocols, while the other twenty-nine were under ovulation induction (OI) therapy. Interleukin-1ß and Interleukin -27 measured in both groups, in the stimulated cycle just prior to administration of HCG and on the second day of the menstrual cycle in the non-stimulated females. Results: Both interleukins have been significantly more significant in the ovulation stimulated group than the non-stimulated one, with P-value of (0.04) for Interleukin -1ß and (0.02) for interleukin-27. Conclusion: The ovulation processes involve an increase in the inflammatory process, as demonstrated by the rise in these interleukins' levels. This increase is more prominent in the process of ovulation induction.

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