Validity of Autotaxin as a Novel Diagnostic Marker for Liver Fibrosis in Egyptian Chronic HCV Patients


  • Wafaa M. Ezzat Internal Medicine Department, National Research Center, Cairo
  • Halla M. Ragab Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, Cairo
  • Nabila Abd El Maksoud Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, Cairo
  • Nour A. Abdulla Hepatology Department, National Hepatology & Tropical Medicine Research Institute, Cairo
  • Yasser A. Elhosary Internal Medicine Department, National Research Center, Cairo



Autotoxin (ATX), HCV, liver fibrosis.


We aimed to detect the validity of serum ATX as a diagnostic marker for liver fibrosis. Forty-eight males and 16 females were enrolled in the current study. Their ages ranged from 29-57 years with mean of 45.09, all were chronically HCV infected. Laboratory assessment was done for all subjects in form of complete blood picture; liver function test; lipid profile and serum detection of ATX. Patients were grouped according to the stage of fibrosis into group 1: fibrosis score 0, 1, 2, 3; group 2: fibrosis score: 4, 5, 6.The mean values of ATX in all studied patients with chronic HCV infection was 63.02 ± 36.29 while that of healthy controls was 65.31 ± 12.24 without any significant difference. Surprisingly, mean values of ATX were higher among patients with group 1 but it did not reach the significant level. In each group of them, the differences between mean values of ATX among different grades of liver fibrosis were insignificant. It was also noticed that the mean values of ATX were higher among men than in women .It was concluded that Autotoxin might not be used as a useful diagnostic marker for liver fibrosis in Egyptian chronic HCV patients.


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How to Cite

Ezzat WM, Ragab HM, El Maksoud NA, Abdulla NA, Elhosary YA. Validity of Autotaxin as a Novel Diagnostic Marker for Liver Fibrosis in Egyptian Chronic HCV Patients. Open Access Maced J Med Sci [Internet]. 2013 Dec. 15 [cited 2021 Apr. 12];1(1):21-6. Available from:



B - Clinical Sciences