Validity of Autotaxin as a Novel Diagnostic Marker for Liver Fibrosis in Egyptian Chronic HCV Patients

Wafaa M. Ezzat; Halla M. Ragab; Nabila Abd El Maksoud; Nour A. Abdulla; Yasser A. Elhosary

doi:10.3889/oamjms.2013.005

Authors

Wafaa M. Ezzat Internal Medicine Department, National Research Center, Cairo
Halla M. Ragab Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, Cairo
Nabila Abd El Maksoud Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Center, Cairo
Nour A. Abdulla Hepatology Department, National Hepatology & Tropical Medicine Research Institute, Cairo
Yasser A. Elhosary Internal Medicine Department, National Research Center, Cairo

DOI:

https://doi.org/10.3889/oamjms.2013.005

Keywords:

Autotoxin (ATX), HCV, liver fibrosis.

Abstract

We aimed to detect the validity of serum ATX as a diagnostic marker for liver fibrosis. Forty-eight males and 16 females were enrolled in the current study. Their ages ranged from 29-57 years with mean of 45.09, all were chronically HCV infected. Laboratory assessment was done for all subjects in form of complete blood picture; liver function test; lipid profile and serum detection of ATX. Patients were grouped according to the stage of fibrosis into group 1: fibrosis score 0, 1, 2, 3; group 2: fibrosis score: 4, 5, 6.The mean values of ATX in all studied patients with chronic HCV infection was 63.02 Â± 36.29 while that of healthy controls was 65.31 Â± 12.24 without any significant difference. Surprisingly, mean values of ATX were higher among patients with group 1 but it did not reach the significant level. In each group of them, the differences between mean values of ATX among different grades of liver fibrosis were insignificant. It was also noticed that the mean values of ATX were higher among men than in women .It was concluded that Autotoxin might not be used as a useful diagnostic marker for liver fibrosis in Egyptian chronic HCV patients.

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