Apitherapy Have a Role in Treatment of Multiple Sclerosis

Authors

  • Suzette I. Helal National Research Center - Research on Children with Special Needs Department, Giza
  • Ahmad Hegazi National Research Center – Child Health, Cairo
  • Khaled Al-Menabbawy National Research Center – Microbiology and Immunology, Cairo

DOI:

https://doi.org/10.3889/oamjms.2014.044

Keywords:

Apitherapy, Multiple Sclerosis, Bee venom, Food Supplements.

Abstract

AIM: Multiple sclerosis (MS) is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged. We Study the effect of Apitherapy in treatment of MS.

MATERIAL AND METHODS: Fifty patients with MS, their ages ranged between 26-71 years, were subjected to complete clinical and neurological history and examination to confirm the diagnosis. All cases were under their regular treatment they were divided into two main groups, Group I received honey, pollen, royal jelly and propolis and were treated with apiacupuncture 3 times weekly, for 12 months, in addition to their medical treatment, while group II remains on their ordinary medical treatment only. Apiacupuncture was done by bee stings for regulating the immune system.

RESULTS: Results revealed that 4 patients showed some improvement regarding their defects in gait, bowel control, constipation and urination, while 12 cases, showed some mild improvement in their movement in bed, and better improvement in bed sores, sensation, and better motor power, only two cases of them were able to stand for few minutes with support.

CONCLUSION: Although Apitherapy is not a curable therapy in MS, but it can be used to minimize the clinical symptoms of MS, and can be included among programs of MS therapy.

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References

Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648):1502-17. DOI: https://doi.org/10.1016/S0140-6736(08)61620-7

Brañas P, Jordan R, Fry-Smith A, Burls A, Hyde C. Treatments for fatigue in multiple sclerosis: a rapid and systematic review. Health Technol Assess. 2000;4(27):1-61. DOI: https://doi.org/10.3310/hta4270

Compston A, Coles A. Multiple sclerosis. Lancet. 2002 Apr 6;359(9313):1221-31. Review. Erratum in: Lancet 2002;360(9333):648. DOI: https://doi.org/10.1016/S0140-6736(02)08220-X

Weinshenker BG. Natural history of multiple sclerosis. Ann Neurol. 1994;36 Suppl:S6-11. DOI: https://doi.org/10.1002/ana.410360704

Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology. 1996;46(4):907-11. DOI: https://doi.org/10.1212/WNL.46.4.907

Feinstein A. The clinical neuropsychiatry of multiple sclerosis (2nd ed. ed.). Cambridge: Cambridge University Press, 2007: p. 20. DOI: https://doi.org/10.1017/CBO9780511543760

Castro HJ, Mendez-Lnocencio JI, Omidvar B, Omidvar J, Santilli J, Nielsen HS Jr, Pavot AP, Richert JR, Bellanti JA. A phase I study of the safety of honeybee venom extract as a possible treatment for patients with progressive forms of multiple sclerosis. Allergy Asthma Proc. 2005;26(6):470-6.

Hegazi AG. Medical importance of bee products. ARI BÄ°LÄ°MÄ° / BEE SCIENCE. 2013; 12(4): 136-146.

Hegazi AG. Propolis an over view. J. Bee Informed. 1998; 5:5,22 –23; 6:723-28.

Janik JE, Wania-Galicia L, Kalauokalani D. Bee stings--a remedy for postherpetic neuralgia? A case report. Reg Anesth Pain Med. 2007;32(6):533-5. DOI: https://doi.org/10.1097/00115550-200711000-00014

Singla RK, Bhat VG. Honey bee sting and venom offering active as well as passive immunization could reduce swine flu pandemic A (H1N1). Med Hypotheses. 2010;74(3):617-8. DOI: https://doi.org/10.1016/j.mehy.2009.08.031

Alqutub A, Masoodi I, Alsayari K, Alomair A. Bee sting therapy-induced hepatotoxicity: A case report. World J Hepatol. 2011;3(10): 268-270. DOI: https://doi.org/10.4254/wjh.v3.i10.268

Swanton JK, Rovira A, Tintore M, Altmann DR, Barkhof F, Filippi M, Huerga E, Miszkiel KA, Plant GT, Polman C, Rovaris M, Thompson AJ, Montalban X, Miller DH. MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study. Lancet Neurol. 2007;6(8):677-86. DOI: https://doi.org/10.1016/S1474-4422(07)70176-X

Ebers GC, Kukay K, Bulman DE, Sadovnick AD, Rice G, Anderson C, Armstrong H, Cousin K, Bell RB, Hader W, Paty DW, Hashimoto S, Oger J, Duquette P, Warren S, Gray T, O'Connor P, Nath A, Auty A, Metz L, Francis G, Paulseth JE, Murray TJ, Pryse-Phillips W, Nelson R, Freedman M, Brunet D, Bouchard JP, Hinds D, Risch N. A full genome search in multiple sclerosis. Nat Genet. 1996;13(4):472-6. DOI: https://doi.org/10.1038/ng0896-472

Wagner P. Buttocks Jiagi Points Book, 1998.

Bowling AC, Stewart TM. Current complementary and alternative therapies of multiple sclerosis. Curr Treatment Options Neurol. 2003;5:55–68. DOI: https://doi.org/10.1007/s11940-003-0022-z

Betke K, Savelsberg W. Stulenphoto metrische hemoglobin best immuny mittles cyanohemoglobin 2. Biochemistry. 1950; 230: 431.

Steel RGD, Torrie JH. Principles and Procedures of Statistics. 2nd ed. McGraw Hill Book Company: New York, 1980.

Ascherio A, Munger KL. Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann Neurol. 2007;61(4):288-99. DOI: https://doi.org/10.1002/ana.21117

Wesselius T, Heersema DJ, Mostert JP, Heerings M, Admiraal-Behloul F, Talebian A, van Buchem MA, De Keyser J. A randomized crossover study of bee sting therapy for multiple sclerosis. Neurology. 2005;65(11):1764-8. DOI: https://doi.org/10.1212/01.wnl.0000184442.02551.4b

Pimenta AM, De Lima ME. Small peptides, big world: biotechnological potential in neglected bioactive peptides from arthropod venoms. J Pept Sci. 2005;11(11):670-6. DOI: https://doi.org/10.1002/psc.701

Goggs R, Vaughan-Thomas A, Clegg PD, Carter SD, Innes JF, Mobasheri A, Shakibaei M, Schwab W, Bondy CA. Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr. 2005;45(3):145-64. DOI: https://doi.org/10.1080/10408690590956341

Kwon YB, Lee HJ, Han HJ, Mar WC, Kang SK, Yoon OB, Beitz AJ, Lee JH. The water-soluble fraction of bee venom produces antinociceptive and anti-inflammatory effects on rheumatoid arthritis in rats. Life Sci. 2002;71(2):191-204. DOI: https://doi.org/10.1016/S0024-3205(02)01617-X

Kim HW, Kwon YB, Ham TW, Roh DH, Yoon SY, Kang SY, Yang IS, Han HJ, Lee HJ, Beitz AJ, Lee JH. General pharmacological profiles of bee venom and its water soluble fractions in rodent models. J Vet Sci. 2004;5(4):309-18. DOI: https://doi.org/10.4142/jvs.2004.5.4.309

Park HJ, Lee SH, Son DJ, Oh KW, Kim KH, Song HS, Kim GJ, Oh GT, Yoon DY, Hong JT. Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit. Arthritis Rheum. 2004;50(11):3504-15. DOI: https://doi.org/10.1002/art.20626

Severino MG, Cortellini G, Bonadonna P, Francescato E, Panzini I, Macchia D, Campi P, Spadolini I, Canonica WG, Passalacqua G. Sublingual immunotherapy for large local reactions caused by honeybee sting: a double-blind, placebo-controlled trial. J Allergy Clin Immunol. 2008;122(1):44-8. DOI: https://doi.org/10.1016/j.jaci.2008.03.031

Park S, Chun HJ, Keum B, Seo YS, Kim YS, Jeen YT, Lee HS, Um SH, Kim CD, Ryu HS. Anaphylactic shock-induced ischemic proctocolitis following bee stings: first case report. Endoscopy. 2010; 42(Suppl 2): E153-E154. DOI: https://doi.org/10.1055/s-0029-1244101

Prado M, Solano-Trejos G, Lomonte B. Acute physiopathological effects of honeybee (Apis mellifera) envenoming by subcutaneous route in a mouse model. Toxicon. 2010; 56: 1007-1017. DOI: https://doi.org/10.1016/j.toxicon.2010.07.005

Lee JD, Park HJ, Chae Y, Lim S. An Overview of Bee Venom Acupuncture in the Treatment of Arthritis. Evid Based Complement Alternat Med. 2005;2(1):79-84. DOI: https://doi.org/10.1093/ecam/neh070

Schumacher MJ, Schmidt JO, Egen NB. Lethality of 'killer' bee stings. Nature. 1989;337(6206):413. DOI: https://doi.org/10.1038/337413a0

Schumacher MJ, Schmidt JO, Egen NB, Lowry JE. Quantity, analysis, and lethality of European and Africanized honey bee venoms. Am J Trop Med Hyg. 1990;43(1):79-86. DOI: https://doi.org/10.4269/ajtmh.1990.43.79

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Published

2014-06-15

How to Cite

1.
Helal SI, Hegazi A, Al-Menabbawy K. Apitherapy Have a Role in Treatment of Multiple Sclerosis. Open Access Maced J Med Sci [Internet]. 2014 Jun. 15 [cited 2024 Apr. 26];2(2):265-70. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2014.044

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Section

B - Clinical Sciences

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