Liver Enzymes in Children with beta-Thalassemia Major: Correlation with Iron Overload and Viral Hepatitis

Authors

  • Khaled M. Salama Faculty of Medicine, Cairo University, Cairo
  • Ola M. Ibrahim National Research Center, Child Health Department, El Buhouth st., Dokki, Cairo 12311
  • Ahmed M. Kaddah Faculty of Medicine, Cairo University, Cairo
  • Samia Boseila National Research Center, Child Health Department, El Buhouth st., Dokki, Cairo 12311
  • Leila Abu Ismail National Research Center, Child Health Department, El Buhouth st., Dokki, Cairo 12311
  • May M. Abdel Hamid National Research Center, Child Health Department, El Buhouth st., Dokki, Cairo 12311

DOI:

https://doi.org/10.3889/oamjms.2015.059

Keywords:

Beta thalassemia, egyptian children, viral hepatitis, iron overload, liver enzymes

Abstract

BACKGROUND: Beta Thalassemia is the most common chronic hemolytic anemia in Egypt (85.1%) with an estimated carrier rate of 9-10.2%. Injury to the liver, whether acute or chronic, eventually results in an increase in serum concentrations of Alanine transaminase (ALT) and Aspartate transaminase (AST).

AIM: Evaluating the potentiating effect of iron overload & viral hepatitis infection on the liver enzymes.

PATIENTS AND METHODS: Eighty (80) thalassemia major patients were studied with respect to liver enzymes, ferritin, transferrin saturation, HBsAg, anti-HCV antibody and HCV-PCR for anti-HCV positive patients.

RESULTS: Fifty % of the patients were anti-HCV positive and 55% of them were HCV-PCR positive. Patients with elevated ALT and AST levels had significantly higher mean serum ferritin than those with normal levels. Anti-HCV positive patients had higher mean serum ferritin, serum ALT, AST and GGT levels and higher age and duration of blood transfusion than the negative group. HCV-PCR positive patients had higher mean serum ferritin and serum ALT and also higher age and duration of blood transfusion than the negative group.

CONCLUSION: Iron overload is a main leading cause of elevated liver enzymes, and presence of HCV infection is significantly related to the increased iron overload.

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Published

2015-05-28

How to Cite

1.
Salama KM, Ibrahim OM, Kaddah AM, Boseila S, Ismail LA, Abdel Hamid MM. Liver Enzymes in Children with beta-Thalassemia Major: Correlation with Iron Overload and Viral Hepatitis. Open Access Maced J Med Sci [Internet]. 2015 May 28 [cited 2022 Aug. 13];3(2):287-92. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2015.059

Issue

Section

B - Clinical Sciences

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