Adipokines Vaspin and Visfatin in Obese Children

Hassan M. Salama; Ashraf Galal; Ayat A. Motawie; Ashraf F. Kamel; Doaa M. Ibrahim; Azza A. Aly; Emman A. Hassan

doi:10.3889/oamjms.2015.123

Authors

Hassan M. Salama National Research Centre, Pediatrics, Cairo
Ashraf Galal National Research Centre, Pediatrics, Cairo
Ayat A. Motawie National Research Centre, Pediatrics, Cairo
Ashraf F. Kamel National Research Centre, Pediatrics, Cairo
Doaa M. Ibrahim Ain Shams University, Faculty of Science, Cairo
Azza A. Aly National Research Centre, Department of Chemical and Clinical Pathology, Cairo
Emman A. Hassan National Research Centre, Pediatrics, Cairo

DOI:

https://doi.org/10.3889/oamjms.2015.123

Keywords:

Vaspin, visfatin, obese, children, adipokines

Abstract

BACKGROUND: Adipokines provides new insights about the physiology, pathology and treatment of obesity.

AIM: We investigated the association between serum vaspin and serum visfatin concentrations with obesity in Egyptian children.

MATERIAL AND METHODS: Twenty two obese children with body mass index (BMI) above 95th percentile; 11 males and 11 females were included in this study. Their mean age was 9.18 Â± 2.8 years. After general clinical examination, fasting blood glucose, triglycerides, total cholesterol and high density lipoprotein cholesterol were measured in cases and controls (n=11). Fasting insulin, vaspin and visfatin were detected using ELIZA. Insulin resistance was estimated by Homeostasis model assessment method (HOMA-IR).

RESULTS: Blood pressure, in both systolic and diastolic measurements was elevated significantly in obese children. Significant elevation of serum insulin and insulin resistance (HOMA/IR) were observed in obese children too. Vaspin and visfatin showed significant elevation in obese children than controls. Significant positive correlations were detected between visfatin and BMI, waist circumference, hip circumference and HOMA/IR. We found that Vaspin and visfatin are higher in obese children.

CONCLUSION: Visfatin but not vaspin correlates positively with waist circumference and HOMA/IR in obese children.

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