Metabolic Syndrome and Cardiovascular Risk Factors in Obese Adolescent

Manal Mansour; Yasser E. Nassef; Mones Abu Shady; Ali Abdel Aziz; Heba A. El Malt

doi:10.3889/oamjms.2016.037

Authors

Manal Mansour Child Health Department, National Research Center, Cairo
Yasser E. Nassef Child Health Department, National Research Center, Cairo
Mones Abu Shady Child Health Department, National Research Center, Cairo
Ali Abdel Aziz Child Health Department, National Research Center, Cairo
Heba A. El Malt Biochemistry Department, National Research Center, Cairo

DOI:

https://doi.org/10.3889/oamjms.2016.037

Keywords:

cholesterol, cardiovascular diseases, body mass index, Blood glucose level, C-reactive protein

Abstract

BACKGROUND: Childhood and adolescent obesity is associated with insulin resistance, abnormal glucose metabolism, hypertension, dyslipidemia, inflammation, liver disease, and compromised vascular function. The purpose of this study was to determine the prevalence of cardiovascular risk factor abnormalities and metabolic syndrome in a sample of obese adolescent as prevalence data might be helpful in improving engagement with obesity treatment in future. The high blood lipid levels and obesity are the main risk factors for cardio vascular diseases. Atherosclerotic process begins in childhood.

AIM: This study aimed to investigate the relationship between obesity in adolescent and their blood lipids levels and blood glucose level.

METHODS: This study was conducted with 100 adolescents of both gender age 12-17 years and body mass index (BMI) greater than 95th percentiles and 100 normal adolescents as control group. The blood samples were collected from all adolescents after overnight fasting (10 hours) to analyze blood lipids (Total cholesterol, high density lipoprotein, low density lipoprotein) and hematological profile (Hemoglobin, platelets and red blood cell, C reactive protein and fasting blood glucose.

RESULTS: There were statistical difference between the two groups for red blood cells (P<0.001), Hemoglobin (P < 0.001) and platelets (P = 0.002), CRP (P = 0.02). Positive correlation was found between the two groups as regards total cholesterol (P = 0.0001), P value was positive for HDL (P = 0.005 and Atherogenic index P value was positive (P = 0.002). Positive correlation was found between the two group as regards fasting blood glucose (P = 0.001).

CONCLUSION:Â Saturated fat was associated with elevated lipid levels in obese children. These results reinforce the importance of healthy dietary habits since child-hood in order to reduce the risks of cardiovascular diseases in adulthood.

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References

Weiss R, Kaufman FR. Metabolic complicationsof childhood obesity: identifying and mitigating the risk. Diabetes Care. 2008;31(Suppl 2):S310â€“S316.

http://dx.doi.org/10.2337/dc08-s273

PMid:18227502

Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med. 2010;362(6):485â€“493.

http://dx.doi.org/10.1056/NEJMoa0904130 DOI: https://doi.org/10.1056/NEJMoa0904130

PMid:20147714 PMCid:PMC2958822

Lenz A, Diamond FBJr. Obesity: the hormonal milieu. Curr Opin Endocrinol Diabetes Obes. 2000;151:9â€“20. DOI: https://doi.org/10.1097/MED.0b013e3282f43a5b

Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics. 2001;108(3):712â€“718.

http://dx.doi.org/10.1542/peds.108.3.712 DOI: https://doi.org/10.1542/peds.108.3.712

PMid:11533341

Beauloye V, Zech F, Tran HT, Clapuyt P, Maes M, Brichard SM. Determinants of early atherosclerosis in obese children andadolescents. J Clin Endocrinol Metab. 2007;92(8):3025â€“3032.

http://dx.doi.org/10.1210/jc.2007-0619 DOI: https://doi.org/10.1210/jc.2007-0619

PMid:17519311

Friedewold W T, Levy RL, Fredickson DS: Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preprtive ultra centrifuge. Clinc Chem. 1972;18:499-502. DOI: https://doi.org/10.1093/clinchem/18.6.499

Juonala M, Magnussen CG, Berenson GS, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med. 2011;365(20):1876â€“1885.

http://dx.doi.org/10.1056/NEJMoa1010112 DOI: https://doi.org/10.1056/NEJMoa1010112

PMid:22087679

Alwan A. Global status report on noncommunicable diseases 2010. World Health Organization. 2011.

van Emmerik NM, Renders CM, van de Veer M, et al. High cardiovascular risk in severely obese young children and adolescents. Arch Dis Child. 2012;97(9):818â€“821.

http://dx.doi.org/10.1136/archdischild-2012-301877 DOI: https://doi.org/10.1136/archdischild-2012-301877

PMid:22826539

l'Allemand-Jander D. Clinical diagnosis of metabolic and cardiovascular risks in overweight children: early development of chronic diseases in the obese child. Int J Obes. 2010;34(Suppl 2):S32â€“S36.

http://dx.doi.org/10.1038/ijo.2010.237 DOI: https://doi.org/10.1038/ijo.2010.237

PMid:21151144

Schwimmer J, Deutsch R, Kahen T, Lavine J, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics. 2006;118(4):1388â€“1393.

http://dx.doi.org/10.1542/peds.2006-1212 DOI: https://doi.org/10.1542/peds.2006-1212

PMid:17015527

Weiss R, Kaufman FR. Metabolic complications of childhood obesity: identifying and mitigating the risk. Diabetes Care. 2008;31(Suppl 2):S310â€“S316.

http://dx.doi.org/10.2337/dc08-s273 DOI: https://doi.org/10.2337/dc08-s273

PMid:18227502

Boodai SA, Reilly JJ. Health related quality of life of obese adolescents in Kuwait. BMC Pediatr. 2013; 13(1):105.

http://dx.doi.org/10.1186/1471-2431-13-105 DOI: https://doi.org/10.1186/1471-2431-13-105

PMid:23845118 PMCid:PMC3710478

World Health Organization. Obesity and overweight facesheet number 311;2011. www. who.Int/ media centre311/en/Index/html.

Mc Nealc, Wilson D, and Dckerson J. Hypercholesterolemia in youth: oppurtunities and obstacles to prevent premature atherosclerotic cardiovascular disease. N Engl J Med. 2007; 357:2329-2337.

Falaschetti E, Hingarani D, Wlincup P. Adiposity and cardiovascular risk factors in a large contemporary population of pre-pubertal children. Eur Heart J. 2010;31:3063-3072.

http://dx.doi.org/10.1093/eurheartj/ehq355 DOI: https://doi.org/10.1093/eurheartj/ehq355

PMid:20972265 PMCid:PMC3001590

Platat C, Wagner A, Simon C. Relationship of physical activity with metabolic syndrome features and low grade inflammation in adolescents. Eur Heart J. 2008;29:792-799.

Morrison J, Glueck J, Yeramanent A. Pediatric triglycerides predict cardiovascular disease events in the youth and adults. Metabolism. 2009;58:1277-1284.

http://dx.doi.org/10.1016/j.metabol.2009.04.009 DOI: https://doi.org/10.1016/j.metabol.2009.04.009

PMid:19501856 PMCid:PMC2774112

Kavey R, Simons-Morton D, Jesus J. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics. 2011;128(5):S213â€“256. DOI: https://doi.org/10.1542/peds.2009-2107C

Daniels SR, Greer FR: Lipid screening and cardiovascular health in childhood. Pediatrics. 2008; 122:198â€“208.

http://dx.doi.org/10.1542/peds.2008-1349 DOI: https://doi.org/10.1542/peds.2008-1349

PMid:18596007

Cook S, Kavey RE. Dyslipidemia and pediatric obesity. Pediatr Clin North Am. 2011;58:1363â€“1373.

http://dx.doi.org/10.1016/j.pcl.2011.09.003 DOI: https://doi.org/10.1016/j.pcl.2011.09.003

PMid:22093856 PMCid:PMC3220879

Sharma S, Roberts LS, Lustig RH, Fleming SE. Carbohydrate intake and cardiometabolic risk factors in high BMI African American children. Nutr Metab (Lond). 2010;7:10.

http://dx.doi.org/10.1186/1743-7075-7-10 DOI: https://doi.org/10.1186/1743-7075-7-10

PMid:20181134 PMCid:PMC2830201