Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report)

Jagoda Stojkovikj; Sead Zejnel; Biljana Gerasimovska; Vesna Gerasimovska; Dragana Stojkovic; Martin Trajkovski; Irina Angelovska; Angela Debreslioska; Smilko Jovanovski

doi:10.3889/oamjms.2016.127

Authors

Jagoda Stojkovikj University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Sead Zejnel University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Biljana Gerasimovska University Clinic of Nephrology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Vesna Gerasimovska University Clinic of Nephrology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Dragana Stojkovic Primary Health Care â€œD-r Dijana Jedikovskaâ€, Skopje
Martin Trajkovski Primary Health Care â€œSt. Elenaâ€, Skopje
Irina Angelovska University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Angela Debreslioska University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje
Smilko Jovanovski University Clinic of Pulmonology and Allergology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2016.127

Keywords:

alveolar haemorrhage, glomerulonephritis, immune system, anti-glomerular basement membrane (anti-GBM) antibodies, Goodpasture's syndrome

Abstract

BACKGROUND: Goodpasture's syndrome was originally described as an association of alveolar haemorrhage and glomerulonephritis. It occurs when the immune system attacks and destroys healthy body tissue.

AIM: We are presenting a patient with a clinical picture of pulmonary haemorrhage and glomerulonephritis, which is diagnosed by renal biopsy.

CASE PRESENTATION: His illness began a year and a half before being diagnosed. In that period he had occasional exacerbations. He was received at our Clinic in extremely serious condition, and after stabilisation of his medical condition, there was made a biopsy of the kidney. The p-ANCA was 8.93 U/ml (neg < 3, poz > 5 U/ml). Histopathological diagnosis of biopsy of the kidney was: Glomerulonephritis extra capillaries focalis, segmentalis et globalis. Based on this he was diagnosed with Goodpasture's syndrome. He received corticosteroid therapy and cyclophosphamide, with good response to treatment, and he is currently in a stable condition, receiving only corticosteroid therapy.

CONCLUSION: Goodpastureâ€™s syndrome is a severe illness caused by the formation of antibodies to the glomerular basement membrane and alveolus with consequential damage to renal and pulmonary function. With current therapy, long-term survival is more than 50%.

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