Experimental Hepatic Carcinogenesis: Oxidative Stress and Natural Antioxidants


  • Velid Unsal GaziosmanpaÅŸa University, Medical Faculty, Department of Biochemistry, Tokat
  • Ergül Belge-KurutaÅŸ Sutcu Imam University, Medical of Faculty, Department of Biochemistry, Kahramanmaras




Hepatic Carcinogenesis, Oxidative stress, Reactive Oxygen Species, Antioxidants, DEN, 2-AAF


Hepatocellular carcinoma is one of the most common cancers in the world, and it is influenced by agents such as DEN, 2-AAF, phenobarbital, alcohol, aflatoxin B1 metabolite or hepatitis viruses (B and C). Oxidative stress is becoming recognized as a key factor in the progression of hepatocarcinogenesis. Reactive oxygen species can play a leading role in initiation and promotion of hepatic carcinogenesis. The metabolites of DEN Diethylnitrosamine (DEN) mediate the binding of tumour promoters by covalently binding to the DNA with one or two oxidation-providing electrons. 2-AAF is the inducer of DEN, and it is involved in tumour formation in the bladder and liver. Reactive Oxygen species (ROS); carbohydrates, lipids, DNA and enzymes, such as affect all important structures. Additionally, an excessive amount of ROS is highly toxic to cells. Antioxidants are protects against ROS, toxic substances, carcinogens. This review focuses on the literature on studies of Hepatic Carcinogenesis, oxidative stress and antioxidant therapy.


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How to Cite

Unsal V, Belge-KurutaÅŸ E. Experimental Hepatic Carcinogenesis: Oxidative Stress and Natural Antioxidants. Open Access Maced J Med Sci [Internet]. 2017 Aug. 12 [cited 2022 Oct. 6];5(5):686-91. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2017.101



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