Relationship of Cord Blood Immunoglobulin E and Maternal Immunoglobulin E with Birth Order and Maternal History of Allergy in Albanian Mother/Neonate Pairs


  • Hatixhe Latifi-Pupovci University of Prishtina, Medical Faculty, Department of Physiology & Immunology, Prishtina, Kosovo
  • Violeta Lokaj-Berisha University of Prishtina, Medical Faculty, Department of Physiology & Immunology, Prishtina, Kosovo
  • Besa Lumezi University of Prishtina, Medical Faculty, Department of Physiology & Immunology, Prishtina, Kosovo



cord blood IgE, birth order, total IgE, maternal allergy, sibship size, Cord blood IgE


BACKGROUND: Previous studies reported that familial factors such as birth order and mothers atopy might influence cord blood levels and development of allergies.

AIM: The aim of the study was to evaluate the relationship of cord blood IgE and maternal IgE with birth order and mothers history of allergy in Albanian mother/neonate pairs.

MATERIAL AND METHODS: Study population represented 291 mother-infant pairs. Mothers were interviewed with a questionnaire for personal history of allergy and pregnancy history whereas serum IgE levels were determined using sandwich IRMA assay.

RESULTS: The mean level of cIgE in neonates with detectable levels was 1.59 (n = 78). No significant difference in means of cIgE was found between first born and later born neonates (p = 0.232) and between neonates of mothers with a negative and positive history of allergy (p = 0.125). Also, no significant difference was found between means of mIgE by birth order, whereas there was a significant difference of mIgE between mothers with and without a history of allergy (p = 0.01). In a group of neonates with detectable cIgE levels, maternal IgE levels were moderately correlated with cIgE levels.

CONCLUSION: Cord blood IgE is not affected by birth order and mothers history of allergy, whereas mothers IgE are affected by the history of allergy but not by birth order.


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How to Cite

Latifi-Pupovci H, Lokaj-Berisha V, Lumezi B. Relationship of Cord Blood Immunoglobulin E and Maternal Immunoglobulin E with Birth Order and Maternal History of Allergy in Albanian Mother/Neonate Pairs. Open Access Maced J Med Sci [Internet]. 2017 Sep. 20 [cited 2023 Mar. 21];5(6):751-6. Available from:



B - Clinical Sciences

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