Dynapenia and Sarcopenia as a Risk Factor for Disability in a Falls and Fractures Clinic in Older Persons
DOI:
https://doi.org/10.3889/oamjms.2018.087Keywords:
Sarcopenia, Dynapenia, Disability, Geriatric health services, fall and fracture servicesAbstract
BACKGROUND: The role of sarcopenia and dynapenia in disability in older persons from falls and bone health clinics remain unknown.
AIM: This study aims to compare the association of sarcopenia and dynapenia with physical and instrumental disability in a population of older persons attending a falls and fractures clinic.
METHODS: This is a cross-sectional study in Manizales, Andes Mountains, Colombia. 534 subjects (mean age = 74, 75% female) Sarcopenia was measured according to the European Working Group on Sarcopenia in Older People (EWGSOP) including an index of skeletal mass, muscle strength, and gait speed. Dynapenia was defined as a handgrip force ≤ 30 kg for men and ≤ 20 kg for women.
RESULTS: Dynapenia and sarcopenia were present in 84.6% and 71.2% respectively. Both were more prevalent in older subjects and women than men. While sarcopenia was associated with body mass index and hypertension, dynapenia was associated with hypothyroidism and visual impairment. After controlling for all covariates, sarcopenia was associated with low IADL and mobility disability.
CONCLUSIONS: Sarcopenia was associated with mobility, ADL and IADL disability. Dynapenia was not associated with disability in this high - risk population. Systematic assessment of sarcopenia should be implemented in falls and fractures clinics to identify sarcopenia and develop interventions to prevent functional decline among elderly individuals.
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Evans WJ. What is sarcopenia?. J Gerontol A Biol Sci Med Sci. 1995; 50A: M5-M8. https://doi.org/10.1093/gerona/50A.Special_Issue.5
Roubenoff R, Hughes VA. Sarcopenia: current concepts. J Gerontol A Biol Sci Med Sci.2000; 55A(12): M716-M724. https://doi.org/10.1093/gerona/55.12.M716
Moritani T, deVries HA. Neural factors versus hypertrophy in the time course of muscle strength gain. American Journal of Physical Medicine. 1979; 58(3):115–130. PMid:453338
Delmonico MJ, Harris TB, Visser M, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. The American Journal of Clinical Nutrition. 2009; 90(6):1579–1585. https://doi.org/10.3945/ajcn.2009.28047 PMid:19864405 PMCid:PMC2777469
Clark BC, Fernhall B, Ploutz-Snyder LL. Adaptations in human neuromuscular function following prolonged unweighting: I. Skeletal muscle contractile properties and applied ischemia efficacy. Journal of Applied Physiology. 2006; 101(1):256-63. https://doi.org/10.1152/japplphysiol.01402.2005 PMid:16514004
Clark BC, Manini TM. What is dynapenia? Nutrition. 2012; 28(5):495–503. https://doi.org/10.1016/j.nut.2011.12.002 PMid:22469110 PMCid:PMC3571692
Clark BC, Manini TM. Sarcopenia =/= dynapenia. Journals of Gerontology- Series A: Biological Sciences and Medical Sciences. 2008; 63(8):829–834. https://doi.org/10.1093/gerona/63.8.829
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E. Sarcopenia: European consensus on definition and diagnosisReport of the European Working Group on Sarcopenia in Older PeopleA. J. Cruz-Gentoft et al. Age and ageing. 2010; 39(4):412-23. https://doi.org/10.1093/ageing/afq034 PMid:20392703 PMCid:PMC2886201
Tanimoto Y, Watanabe M, Sun W, Sugiura Y, Hayashida I, Kusabiraki T, Tamaki J. Sarcopenia and falls in community-dwelling elderly subjects in Japan: Defining sarcopenia according to criteria of the European Working Group on Sarcopenia in Older People. Archives of gerontology and geriatrics. 2014; 59(2):295-9. https://doi.org/10.1016/j.archger.2014.04.016 PMid:24852668
Hita-Contreras F, MartÃnez-Amat A, Cruz-DÃaz D, Pérez-López FR. Osteosarcopenic obesity and fall prevention strategies. Maturitas. 2015; 80(2):126-32. https://doi.org/10.1016/j.maturitas.2014.11.009 PMid:25533145
Huo YR, Suriyaarachchi P, Gomez F, Curcio CL, Boersma D, Muir SW, Montero-Odasso M, Gunawardene P, Demontiero O, Duque G. Phenotype of osteosarcopenia in older individuals with a history of falling. Journal of the American Medical Directors Association. 2015; 16(4):290-5. https://doi.org/10.1016/j.jamda.2014.10.018 PMid:25512216
da Silva Alexandre T, Duarte YD, Santos JF, Wong R, Lebrão ML. Sarcopenia according to the european working group on sarcopenia in older people (EWGSOP) versus Dynapenia as a risk factor for disability in the elderly. The journal of nutrition, health & aging. 2014; 18(5):547-53. https://doi.org/10.1007/s12603-014-0465-9
Velázquez Alva MD, Irigoyen Camacho ME, Delgadillo Velázquez J, Lazarevich I. The relationship between sarcopenia, undernutrition, physical mobility and basic activities of daily living in a group of elderly women of Mexico City. Nutricion hospitalaria. 2013; 28(2).
Baztán JJ, Pérez del Molino J, Alarcón T, San Cristóbal E, Izquierdo G, Manzarbeitia J. Ãndice de Barthel: instrumento válido para la valoración functional de pacientes con enfermedad cerebrovascular. Revista Espa-ola de GeriatrÃa y GerontologÃa. 1993; 28(1):32-40.
Guralnik JM, Simonsick EM. 1 Physical disability in older Americans. Journal of Gerontology. 1993; 48(Special_Issue):3-10.
Lawton MP. The functional assessment of elderly people. Journal of the American Geriatrics Society. 1971; 19(6):465-81. https://doi.org/10.1111/j.1532-5415.1971.tb01206.x PMid:5094650
Ottenbacher KJ, Ostir GV, Peek MK, Snih SA, Raji MA, Markides KS. Frailty in older mexican americans. Journal of the American Geriatrics Society. 2005; 53(9):1524-31. https://doi.org/10.1111/j.1532-5415.2005.53511.x PMid:16137282 PMCid:PMC1388072
Lee RC, Wang Z, Heo M, Ross R, Janssen I, Heymsfield SB. Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models–. The American journal of clinical nutrition. 2000; 72(3):796-803. PMid:10966902
Rech CR, Dellagrana RA, Marucci MD, Petroski EL. Validity of anthropometric equations for the estimation of muscle mass in the elderly. Revista Brasileira de Cineantropometria & Desempenho Humano. 2012; 14(1):23-31.
Delmonico MJ, Harris TB, Lee JS, Visser M, Nevitt M, Kritchevsky SB, Tylavsky FA, Newman AB. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. Journal of the American Geriatrics Society. 2007; 55(5):769-74. https://doi.org/10.1111/j.1532-5415.2007.01140.x PMid:17493199
Newman AB, Kupelian V, Visser M, Simonsick E, Goodpaster B, Nevitt M, Kritchevsky SB, Tylavsky FA, Rubin SM, Harris TB. Sarcopenia: alternative definitions and associations with lower extremity function. Journal of the American Geriatrics Society. 2003; 51(11):1602-9. https://doi.org/10.1046/j.1532-5415.2003.51534.x PMid:14687390
Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. Journal of applied physiology. 2003; 95(5):1851-60. https://doi.org/10.1152/japplphysiol.00246.2003 PMid:14555665
Gómez JF, Curcio CL, Alvarado B, Zunzunegui MV, Guralnik J. Validity and reliability of the Short Physical Performance Battery (SPPB): a pilot study on mobility in the Colombian Andes. Colombia medica. 2013; 44(3):165-71. PMid:24892614 PMCid:PMC4002038
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. Journal of psychiatric research. 1975; 12(3):189-98. https://doi.org/10.1016/0022-3956(75)90026-6
Icaza MG, Albala C. Minimental State Examinations (MMSE) del estudio de demencia en Chile: análisis estadÃstico. InOPS. Investigaciones en Salud Pública Documentos Técnicos 1999 Apr (Vol. 7). Organización Panamericana de la Salud.
Baker FM, Espino Dv. A spanish version of the geriatric depression scale in mexicanâ€american elders. International Journal of Geriatric Psychiatry. 1997; 12(1):21-5. bhttps://doi.org/10.1002/(SICI)1099-1166(199701)12:1<21::AID-GPS444>3.0.CO;2-2
Tanimoto Y, Watanabe M, Sun W, Hirota C, Sugiura Y, Kono R, Saito M, Kono K. Association between muscle mass and disability in performing instrumental activities of daily living (IADL) in community-dwelling elderly in Japan. Archives of gerontology and geriatrics. 2012; 54(2):e230-3. https://doi.org/10.1016/j.archger.2011.06.015 PMid:21831461
Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD. Epidemiology of sarcopenia among the elderly in New Mexico. American journal of epidemiology. 1998; 147(8):755-63. https://doi.org/10.1093/oxfordjournals.aje.a009520 PMid:9554417
Melton LJ, Khosla S, Crowson CS, O'connor MK, O'fallon WM, Riggs BL. Epidemiology of sarcopenia. Journal of the American Geriatrics Society. 2000; 48(6):625-30. https://doi.org/10.1111/j.1532-5415.2000.tb04719.x PMid:10855597
Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. Journal of the American Geriatrics Society. 2002; 50(5):889-96. https://doi.org/10.1046/j.1532-5415.2002.50216.x PMid:12028177
Janssen I. Influence of sarcopenia on the development of physical disability: the Cardiovascular Health Study. Journal of the American Geriatrics Society. 2006; 54(1):56-62. https://doi.org/10.1111/j.1532-5415.2005.00540.x PMid:16420198
Janssen I, Baumgartner RN, Ross R, Rosenberg IH, Roubenoff R. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. American journal of epidemiology. 2004; 159(4):413-21. https://doi.org/10.1093/aje/kwh058 PMid:14769646
Rolland Y, Czerwinski S, Van Kan GA, Morley JE, Cesari M, Onder G, Woo J, Baumgartner R, Pillard F, Boirie Y, Chumlea WM. Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. The Journal of Nutrition Health and Aging. 2008; 12(7):433-50. https://doi.org/10.1007/BF02982704
Delmonico MJ, Harris TB, Lee JS, Visser M, Nevitt M, Kritchevsky SB, Tylavsky FA, Newman AB. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. Journal of the American Geriatrics Society. 2007; 55(5):769-74. https://doi.org/10.1111/j.1532-5415.2007.01140.x PMid:17493199
Tanimoto Y, Watanabe M, Sun W, Tanimoto K, Shishikura K, Sugiura Y, Kusabiraki T, Kono K. Association of sarcopenia with functional decline in communityâ€dwelling elderly subjects in Japan. Geriatrics & gerontology international. 2013; 13(4):958-63. https://doi.org/10.1111/ggi.12037 PMid:23452074
Cesari M, Rolland Y, Abellan Van Kan G, Bandinelli S, Vellas B, Ferrucci L. Sarcopenia-related parameters and incident disability in older persons: results from the "invecchiare in Chianti" study. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2014; 70(4):457-63. https://doi.org/10.1093/gerona/glu181 PMid:25320055 PMCid:PMC4375415
Gariballa S, Alessa A. Sarcopenia: prevalence and prognostic significance in hospitalized patients. Clinical nutrition. 2013; 32(5):772-6. https://doi.org/10.1016/j.clnu.2013.01.010 PMid:23395102
Rossi AP, Fantin F, Micciolo R, Bertocchi M, Bertassello P, Zanandrea V, Zivelonghi A, Bissoli L, Zamboni M. Identifying sarcopenia in acute care setting patients. Journal of the American Medical Directors Association. 2014; 15(4):303-e7. https://doi.org/10.1016/j.jamda.2013.11.018n PMid:24508329
Muscaritoli M, Lucia S, Molfino A. Sarcopenia in critically ill patients: the new pandemia. Minerva anestesiologica. 2013; 79(7):771-7. PMid:23370125
Senior HE, Henwood TR, Beller EM, Mitchell GK, Keogh JW. Prevalence and risk factors of sarcopenia among adults living in nursing homes. Maturitas. 2015; 82(4):418-23. https://doi.org/10.1016/j.maturitas.2015.08.006 PMid:26341045
Landi F, Liperoti R, Fusco D, Mastropaolo S, Quattrociocchi D, Proia A, Russo A, Bernabei R, Onder G. Prevalence and risk factors of sarcopenia among nursing home older residents. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2011; 67(1):48-55.
Velázquez Alva MD, Irigoyen Camacho ME, Delgadillo Velázquez J, Lazarevich I. The relationship between sarcopenia, undernutrition, physical mobility and basic activities of daily living in a group of elderly women of Mexico City. Nutricion hospitalaria. 2013;28(2).
Cruz-Jentoft AJ, Landi F, Schneider SM, Zú-iga C, Arai H, Boirie Y, Chen LK, Fielding RA, Martin FC, Michel JP, Sieber C. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age and ageing. 2014; 43(6):748-59. https://doi.org/10.1093/ageing/afu115 PMid:25241753 PMCid:PMC4204661
Cuesta F, Formiga F, Lopez-soto A, Masanes F, Ruiz D, Artaza I, Salvà A, Serra-Rexach JA, Rojano I Luque X, Cruz-Jentoft AJ. Prevalence of sarcopenia in patients attending outpatient geriatric clinics: the ELLI study. Age and ageing. 2015; 44(5):807-9. https://doi.org/10.1093/ageing/afv088 PMid:26220989
Beaudart C, Reginster JY, Slomian J, Buckinx F, Locquet M, Bruyère O. Prevalence of sarcopenia: the impact of different diagnostic cut-off limits. J Musculoskelet Neuronal Interact. 2014; 14(4):425-31. https://doi.org/10.1016/S1878-7649(14)70510-8
Landi F, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, Bernabei R, Onder G. Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clinical nutrition. 2012; 31(5):652-8. https://doi.org/10.1016/j.clnu.2012.02.007 PMid:22414775
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