Increasing Atherosclerosis in Streptozotocin-Induced Diabetes into Four Groups of Mice


  • Yunita Sari Pane Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan
  • Aznan Lelo Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan
  • Kiking Ritarwan Department of Neurology, Adam Malik General Hospital, Faculty of Medicine, Universitas Sumatera Utara, Medan
  • Nerdy Nerdy Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan



Atherosclerosis, Streptozotocin, Diabetes, Mice


AIM: To study the protective effect of medicines on the formation of atherosclerosis in mice, it is needed to conduct the study in mice which is not genetically diabetic mice induced by streptozotocin (STZ) to produce hyperglycemia and atherosclerosis, compared with mice treated by yolk or its combination.

MATERIAL AND METHODS: Fifty-six mice, Double Deutch Webster strain, male, receive  10 weeks, 20 - 30 gr bodyweight were divided into 4 groups (n = 14) i.e. control (do not received any agents), STZ (45 mg/kg/BW was injected intraperitoneally for 5 days), yolk (0.2 cc orally daily for 6 weeks), and combination of STZ and yolk (STZ: 45 mg/kg/BW intraperitoneally add 0.2 cc yolk orally). All animals were executed in the 42nd day. Then, the aorta of the mice’s heart tissue was histopathology examined. Blood glucose and cholesterol levels were determined every week.

RESULTS: Hyperglycemia occurred in mice induced by STZ injection with the highest BGL (521.8 ± 48.2 mg/dl; 188.4%) in the 4th-week observation; after that BGL decrease. We found that, except the control, all treatment groups with STZ, egg yolk, and combination underwent atherosclerosis.

CONCLUSION: The present study was able to demonstrate the occurrence of atherosclerosis in mice treated by STZ accompanied with increasing blood glucose and cholesterol level.


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How to Cite

Pane YS, Lelo A, Ritarwan K, Nerdy N. Increasing Atherosclerosis in Streptozotocin-Induced Diabetes into Four Groups of Mice. Open Access Maced J Med Sci [Internet]. 2018 Feb. 14 [cited 2024 May 26];6(2):287-92. Available from:



A - Basic Science

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