Epidemiological Profile of Acute Viral Encephalitis in a Sample of Egyptian Children

Bassant Meligy; Dalia Kadry; Iman H. Draz; Huda Marzouk; Nevine R. El Baroudy; Amira Sayed El Rifay

doi:10.3889/oamjms.2018.103

Authors

Bassant Meligy Department of Paediatrics, Faculty of Medicine, Cairo University, Cairo
Dalia Kadry Department of Microbiology, Faculty of Medicine, Cairo University, Cairo
Iman H. Draz Department of Paediatrics, Faculty of Medicine, Cairo University, Cairo
Huda Marzouk Department of Paediatrics, Faculty of Medicine, Cairo University, Cairo
Nevine R. El Baroudy Department of Paediatrics, Faculty of Medicine, Cairo University, Cairo
Amira Sayed El Rifay Departments of Child Health, National Research Centre, Cairo

DOI:

https://doi.org/10.3889/oamjms.2018.103

Keywords:

Viral encephalitis, Pediatric, PCR, Outcome

Abstract

INTRODUCTION: Acute encephalitis syndrome (AES) is a considerable public health problem.

AIM: This study was designed to describe the aetiology, demographic features, clinical picture, short-term outcome and risk factors of mortality of children with viral encephalitis in Egyptian children.

METHODS: PCR detection of viruses in the CSF of pediatric patients admitted to the pediatric unit or ICU Cairo University Pediatric hospital presenting with encephalitis syndrome.

RESULTS: Of the 96 patients included in the study, viral etiological agents were detected in 20 cases (20.8%), while 76 patients (79.2%) had no definite viral aetiology. The most abundant virus detected was Enterovirus (EV) in fourteen (14.5%), two (2.1%) were positive for human herpes simplex virus 6 (HSV-6), one (1.0%), human herpes simplex virus1 (HSV-1), one (1.0%) Epstein Barr virus (EBV), one (1.0%), cytomegalovirus (CMV) and one (1.0%) with varicella-zoster virus (VZV). On the short term outcome, 22 (22.9) patients died, and 74 (77.1%) survived. Severity outcome among survival was vegetative in three cases (4%) severe in 9 (12.16%), moderate in 14 (18.9%), mild in 29 (39.2%) and full recovery in 19 (25.6%). Mortality risk factors for younger age, the presence of apnea, the need for mechanical ventilation and the presence of abnormal CT findings were all significantly associated with fatal outcome (p < 0.05).

CONCLUSION: Enterovirus was the most common cause of encephalitis among Egyptian children. Mortality was correlated with younger age and disease severity at admission. Sequelae were high among infected children.

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