Myasthenia Gravis and Associated Diseases

Authors

  • Nikolina Tanovska University Clinic for Neurology, Clinical Centre "Mother Theresa", Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Gabriela Novotni University Clinic for Neurology, Clinical Centre "Mother Theresa", Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Slobodanka Sazdova-Burneska University Clinic for Neurology, Clinical Centre "Mother Theresa", Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Igor Kuzmanovski University Clinic for Neurology, Clinical Centre "Mother Theresa", Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Bojan Boshkovski University Clinic for Neurology, Clinical Centre "Mother Theresa", Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Goran Kondov University Clinic for Thoracic and Vascular Surgery, Clinical Centre "Mother Theresa", Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Marija Jovanovski-Srceva University Clinic for Anesthesia and Reanimation, Clinical Centre “Mother Theresa”, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Anita Kokareva University Clinic for Anesthesia and Reanimation, Clinical Centre “Mother Theresa”, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Rozalinda Isjanovska Institute for Epidemiology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje

DOI:

https://doi.org/10.3889/oamjms.2018.110

Keywords:

Myasthenia gravis, Autoimmune disease, Associated condition, Thymus, Tumor, Thymectomy

Abstract

BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease caused by the action of specific antibodies to the postsynaptic membrane of the neuromuscular junction, leading to impaired neuromuscular transmission. Patients with MG have an increased incidence of other autoimmune diseases.

AIM: to determine the presence of other associated diseases in patients with MG.

METHOD: A group of 127 patients with MG followed in 10 years period, in which the presence of other associated diseases has been analysed.

RESULTS: The sex ratio is in favour of the female sex, the average age of the initial manifestation of the disease is less than 50 years, 65.4% of the patients with MG have another disease. 15.0% patients have associated another autoimmune disease. Thyroid disease is the most common associated with MG, rarely rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other autoimmune diseases. Other diseases include hypertension, heart disease, diabetes, respiratory diseases, dyslipidemia. 10.2% of the patients are diagnosed with extrathymic tumours of various origins.

CONCLUSION: Associated diseases are common in patients with MG, drawing attention to the possible common basis for their coexistence, as well as their impact on the intensity and treatment of the disease.

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Published

2018-03-05

How to Cite

1.
Tanovska N, Novotni G, Sazdova-Burneska S, Kuzmanovski I, Boshkovski B, Kondov G, Jovanovski-Srceva M, Kokareva A, Isjanovska R. Myasthenia Gravis and Associated Diseases. Open Access Maced J Med Sci [Internet]. 2018 Mar. 5 [cited 2024 Mar. 28];6(3):472-8. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.110

Issue

Section

B - Clinical Sciences

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