Correlation between 25-Hydroxyvitamin D and Lipid Profile among Children with Beta Thalassemia Major

Authors

  • Christian Nasir Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan
  • Nelly Rosdiana Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan
  • Aridamuriany Dwiputri Lubis Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan

DOI:

https://doi.org/10.3889/oamjms.2018.388

Keywords:

Thalassemia beta major, lipid profile, vitamin D

Abstract

BACKGROUND: Beta thalassemia major is associated with lipid profile abnormalities, presented as a lower level of total cholesterol (TC), low-density lipoproteins (LDL), high-density lipoprotein (HDL), and higher triglyceride level; increasing risk for cardiovascular complications. The previous studies indicated that Vitamin D give a positive impact on the lipid profile in healthy children population. However, its role needs to be determined in a high-risk group of children with beta-thalassemia major.

AIM: To determine the correlation between vitamin D (25-OHD) and lipid profile among children with beta-thalassemia major.

METHODS: A cross-sectional study was conducted in a general tertiary hospital in Medan, Sumatera Utara, Indonesia from January to March 2018. Subjects were children aged below 18-year-old with beta-thalassemia major. The measurement of vitamin D (25-OHD) level and 10-12 hour overnight fasting serum lipid profile including total cholesterol, triglyceride, HDL, and LDL were performed. The analysis was done using Pearson’s correlation and Fisher test. P value < 0.05 was considered significant.

RESULTS: Forty-five subjects were enrolled in this study, with serum ferritin level ranged from 1017 to 13372 ng/mL. The prevalence of vitamin D deficiency (a 25-OHD level less than 20 ng/mL) in this study was 40%, with mean value at 20.6 (SD 5.3) ng/mL. The markers for cardiovascular risk were observed to be elevated, both in Atherogenic Index Plasma (0.32 ± 0.25) and TC: HDL ratio (4.2 ± 1.5). Statistical analysis revealed that Vitamin D had positive correlation with total cholesterol (r = 0.302, p = 0.044) and HDL (r = 0.297, p = 0.048). There was no significant correlation between both vitamin D and triglyceride (p = 0.305), or vitamin D and LDL (p = 0.727).

CONCLUSION: Vitamin D correlated positively with total cholesterol and HDL in children with beta-thalassemia major. Positive correlation to HDL indicated a beneficial effect of vitamin D to reduce the risk of cardiovascular complication.

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Published

2018-10-10

How to Cite

1.
Nasir C, Rosdiana N, Lubis AD. Correlation between 25-Hydroxyvitamin D and Lipid Profile among Children with Beta Thalassemia Major. Open Access Maced J Med Sci [Internet]. 2018 Oct. 10 [cited 2021 Apr. 12];6(10):1790-4. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2018.388

Issue

Section

A - Basic Science