Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population
DOI:
https://doi.org/10.3889/oamjms.2018.421Keywords:
Procalcitonin, Non-small cell lung cancer, Adenocarcinoma, Lung cancerAbstract
BACKGROUND: Serum Procalcitonin (PCT) is a biomarker that is frequently used to diagnose an infection. In some cases of thoracic malignancy, procalcitonin level appears to increase. However, the role of procalcitonin to diagnose malignancy is not certain yet, and the causes have not been known.
AIM: This study aimed to investigate procalcitonin levels in non-small cell lung cancer patients.
METHODS: This was an observational study with a cross-sectional design. All lung cancer patients did not diagnose based on cytology/histopathology results with no evidence nor were signs and symptoms of infection recruited through consecutive sampling. The subtypes of lung cancer include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma, staged III and IV. The procalcitonin levels were analysed from blood using immunofluorescent assay. Data were then analysed with the Chi-Square test by Epi Infoâ„¢ 7 programs in which p-value < 0.05 was considered statistically significant.
RESULTS: A total of 68 lung cancer patients fulfilled the criteria of this study, 55 men (80.9%) and 13 women (19.1%). The highest percentage of cytology/histopathology type found was adenocarcinoma (80.9%), and 60.3% of those were diagnosed in stage IV. An increased procalcitonin level (greater than 0.01 ng/mL) occurred in 80.9% of Non-Small Cell Lung Cancer (NSCLC) patients. It appears that the higher the stage of lung cancer, the lower procalcitonin levels would be, although it was not statistically significant. There was no association between lung cancer subtype with procalcitonin levels.
CONCLUSION: An increased level of procalcitonin may be an indication not only for infection but also for Non-Small Cell Lung Cancer.
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Soeroso NN, Soeroso L, Syafiuddin T. Kadar Carcinoembryogenic Antigen (CEA) Serum Penderita Kanker Paru Karsinoma Bukan Sel Kecil di RSUP Adam Malik.
Furrukh M. Tobacco Smoking and Lung Cancer. Sultan Qaboos Univ Med J. 2013; 13(3):345-358. https://doi.org/10.12816/0003255 PMid:23984018 PMCid:PMC3749017
Soeroso N. N. Soeroso L. Syafiuddin L. Level of Serum Carcinoembryogenic Antigen (CEA) In Non Small Cell Lung Cancer (NSCLC) at Adam Malik Hospital Medan. J Respir Indo. 2014; 34:17-25.
Molina JR, Yang P, Cassivi SD. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008; 83(5):584-594. https://doi.org/10.1016/S0025-6196(11)60735-0
Vincenzi B, Fioroni I, Pantano F. Procalcitonin as diagnostic marker of infection in solid tumors patients with fever. Sci Rep. 2016; 6:28090. https://doi.org/10.1038/srep28090 PMid:27312877 PMCid:PMC4911581
Keramidaris D, Koronakis N, Lagoudinakis EE. Procalcitonin in patients with colorectal cancer. J BUON. 2013; 623-628. PMid:24065474
Zell JA, Chang JC. Neoplastic fever; a neglected paraneoplastic syndrome. Support Care Cancer. 2005; 13(11):870-877. https://doi.org/10.1007/s00520-005-0825-4 PMid:15864658
Becker KL, Nylen ES, White JC, Muller B, Snider RH. Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis:a journey from procalcitonin back to in precursors. J Clin Endocrinol. Metab. 2004; 89(4):1512-1525. https://doi.org/10.1210/jc.2002-021444 PMid:15070906
Shomali W, Hachem R, Chaftari AM, Jiang Y, Bahu R et al. Can procalcitonin distinguish infectious fever from tumor-related fever in non neutropenic cancer patients?. Cancer. 2012; 118(23):5823-5812. https://doi.org/10.1002/cncr.27602 PMid:22605389
Avrillon V, Locatelli-Sanchez M, Folliet L. Lung Cancer May Increase Serum Procalcitonin Level. Infect Disord Drug Targets. 2015; 15(1):57-64. https://doi.org/10.2174/1871526515666150320162950 PMid:25809625
Ryan H, Trosclair A, Gfroerer J. Adult current smoking: differences in definitions and prevalence estimates—NHIS and NSDUH, 2008. Journal of environmental and public health. 2012; 2012.
The Indonesia Society of Respirology. Chronic Obstructive Pulmonary Disease (COPD): Diagnosis and Management COPD, 2011.
Aareleid T, Zimmermann M, Baburin A. Divergent trends in lung cancer incidence by gender, age and histological type in Estonia: a nationwide population-based study. BMC Cancer. 2017; 17: 596. https://doi.org/10.1186/s12885-017-3605-x PMid:28854969 PMCid:PMC5577806
Ridge C, McErlean A, Ginsberg M. Epidemiology of Lung Cancer. Semin Intervent Radiol. 2013; 30(2):93-98. https://doi.org/10.1055/s-0033-1342949 PMid:24436524 PMCid:PMC3709917
Soeroso NN, Sinaga BYM, Zain-Hamid R, Sadewa AH, Syahruddin B. The CYP2A13 Arg257cys polymorphism and its relationship to lung cancer. Stem Cell Oncology. 2018; 265-269. https://doi.org/10.1201/9781351190152-57
Soeroso NN, Zain-Hamid R, Sinaga BYM, Sadewa AH, et al. The role of CYP2A6 genetic polymorphism in nicotine dependence and tobacco consumption among Bataknese male smokers. Open Access Maced J Med Sci. 2018; 6(5):864-866. https://doi.org/10.3889/oamjms.2018.224 PMid:29875862 PMCid:PMC5985876
World Health Organization: Age Adjusted Death Rate Estimates: 2017. Available from: https://www.worldlifeexpectancy.com/indonesia-lung-cancers
Soeroso NN, Zain-Hamid R, Sinaga BYM, Sadewa AH, et al. Genetic polymorphism of CYP2A6 and its relationship with nicotine metabolism in male Bataknese smokers suffered from lung cancer in Indonesia. Open Access Maced J Med Sci. 2018; 6(7):1199-1205. https://doi.org/10.3889/oamjms.2018.259 PMid:30087722 PMCid:PMC6062282
Syahruddin E, Wulandari L, Muktiati NS, Rima A, Soeroso N, Ermayanti S. Uncommon EGFR mutations in cytological specimens of 1,874 newly diagnosed Indonesian lung cancer patients. Lung Cancer: Targets and Therapy. 2018; 9:25–34. https://doi.org/10.2147/LCTT.S154116 PMid:29615847 PMCid:PMC5870662
Ghillani PP, Motte P, Troalen F. 'Identification and measurement of procalcitonin precursors in serum of patients with malignant diseases. Cancer Res. 1989; 49:6845-6851. PMid:2555054
Chaftari AM, Hachem R, Reitzel R. Role of procalcitonin and interleukin-6 in predicting cancer, and its progression independent of infection. PLoS One. 2015; 10(7). https://doi.org/10.1371/journal.pone.0130999
Patout M, Salaun M, Brunel V. Diagnostic and prognostic value of serum procalcitonin concentrations in primary lung cancers. Clin Biochem. 2014; 47(18):263-267. https://doi.org/10.1016/j.clinbiochem.2014.09.002 PMid:25218831
Matzaraki V, Alexandraki KI, Venetsanou K et al. Evaluation of serum procalcitonin and interleukin-6 levels as markers of liver metastasis. Clin Biochem. 2007; 40:336-42. https://doi.org/10.1016/j.clinbiochem.2006.10.027 PMid:17306245
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Copyright (c) 2018 Noni Novisari Soeroso, Muhammad Faiz Tanjung, Dina Afiani, Andika Pradana, Setia Putra Tarigan, Arlinda Sari Wahyuni
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