Improving Treatment Outcome of Pemphigus Vulgaris on Vietnamese Patients by Using Desmoglein Elisa Test
DOI:
https://doi.org/10.3889/oamjms.2019.003Keywords:
Pemphigus, Desmoglein, ELISAAbstract
BACKGROUND: Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1).
AIM: The aims of this study were to evaluate the before and after treatment outcome with corticosteroid, using Desmoglein ELISA test.
METHOD: Forty patients with Pemphigus include 36 PV and 4 PF (28 women, 12 women) were enrolled. The titers of Dsg in pemphigus patients by using ELISA test were done before and 1-month treatment
RESULTS: Both anti-Dsg1 and anti-Dsg3 levels were significantly reduced after treatment (P < 0.05). The severity of skin lesions was correlated with anti-Dsg1 antibody level and the severity of oral lesions was significantly correlated with anti-Dsg 3 antibody levels (p < 0.05)
CONCLUSION: It is recommended that we can predict and improve the outcome of treatment by using Desmoglein ELISA test.
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PMid:29484008 PMCid:PMC5816282
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Copyright (c) 2019 Anh Tran Thi Van, Thuong Van Nguyen, Sau Nguyen Huu, Lan Pham Thi, Phuong Pham Thi Minh, Nghi Dinh Huu, Van Tran Cam, My Le Huyen, Minh Vu Nguyet, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
