Serum Interleukin-27 Level in Different Clinical Stages of Lung Cancer
DOI:
https://doi.org/10.3889/oamjms.2019.018Keywords:
Interleukin 27, Lung Cancer, cytokine, NSCLC, SCLC, SerumAbstract
BACKGROUND: Advanced lung cancer is indicated with rapid disease development. Interleukin 27 (IL-27) is regarded as a cytokine with anti-tumour activities.
AIM: Since, the impact of type of lung cancer on the level of IL-27 in patient’s serum has not yet been investigated; current study evaluated the clinical stages according to American Joint Committee on Cancer (AJCC) criteria, Tumor-Node-Metastasis (TNM) stage and the lung cancer spread (localized or widespread) and it's correlation with serum IL-27.
MATERIAL AND METHODS: Thirty patients with confirmed histopathological lung cancer and 30 cancer-free healthy individuals as the control group were included in the current study. Patients group were assigned to either small cell lung cancer group (SCLC) or non-small cell lung cancer (NSCLC) according to the clinical features and the results of lung biopsy specimens. Level of IL-27 was quantified with enzyme-linked immunosorbent assay (ELISA) test in serum samples.
RESULTS: A significant increase in serum IL-27 level was noticed in individuals with lung cancer in comparison with the control group. The level of serum IL-27 in the NSCL squamous carcinoma (NSCLC-Sc) type was significantly greater than in the NSCLC adenocarcinoma (NSCLC-Ad) type, and in both groups, this variable was more than the control group. The serum IL-27 content level was greater in stage III versus stage IV.
CONCLUSION: The current research confirmed the existence of the anti-tumour components in patients with NSCLC. IL-27 can be utilised in diagnosis and screening in early stages of lung cancer along with the management of patients. Different levels of IL-27 in different types of lung cancers in the current study can lead to design more comprehensive studies in the future.
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Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. Global cancer statistics. CA Cancer J Clin. 2011; 61(2):69-90. https://doi.org/10.3322/caac.20107 PMid:21296855 DOI: https://doi.org/10.3322/caac.20107
Khan D, Choudhary A, Dutta A, Khan I. Tuberculosis of the glans penis mimicking as carcinoma. Int J Mycobacterial. 2016; 5(3):341-342. https://doi.org/10.1016/j.ijmyco.2016.04.003 PMid:27847021 DOI: https://doi.org/10.1016/j.ijmyco.2016.04.003
Velayati AA, Bakayev V, Bahadori M, et al. Religious and cultural traits in HIV/AIDS epidemics in sub-Saharan Africa. Arch Iranian Med. 2007; 10(4):486–497. PMid:17903054
McIntyre A, Ganti AK. Lung cancer-A global perspective. J Surg Oncol. 2017; 115(5):550-4. https://doi.org/10.1002/jso.24532 PMid:28418583 DOI: https://doi.org/10.1002/jso.24532
Errarhay S, Hmidani N, Fatmi H, Saadi H, Bouchikhi C, Amarti A, et al. Post-menopausal endometrial tuberculosis mimicking carcinoma: An important differential diagnosis to consider. Int J Mycobacteriol. 2013; 2(2):118-20. https://doi.org/10.1016/j.ijmyco.2013.04.004 PMid:26785900
Wollina U, Hansel G, Langner D, Koch A, Schönlebe J, Tchernev G. Rapid Evolving Unilateral Indurated Oozing Facial Plaques in a Patient with Head-and-Neck Cancer: Peripheral T-Cell Lymphoma Not Otherwise Specified (NOS). Open Access Maced J Med Sci. 2017; 5(4):476-479. https://doi.org/10.3889/oamjms.2017.085 PMid:28785337 PMCid:PMC5535662 DOI: https://doi.org/10.3889/oamjms.2017.085
Rihawi A, Huang G, Al-Hajj A, Bootwala Z. A case of tuberculosis and adenocarcinoma coexisting in the same lung lobe. Int J Mycobacteriol. 2016; 5(1):80-2. https://doi.org/10.1016/j.ijmyco.2015.07.001 PMid:26927994 DOI: https://doi.org/10.1016/j.ijmyco.2015.07.001
Kiani A, Taghavi K, Rokni-Yazdi H, Abedini A. Application of Microwave Ablation for Treating Pulmonary Adenocarcinoma: A Case Report. Tanaffos. 2017; 16(4):304-308. PMid:29849688 PMCid:PMC5971762
Idrees F, Kamal S, Irfan M, Ahmed R. Endobronchial tuberculosis presented as multiple endobronchial vesicular lesions. Int J Mycobacteriol. 2015; 4(2):154-7. https://doi.org/10.1016/j.ijmyco.2015.02.005 PMid:26972885 DOI: https://doi.org/10.1016/j.ijmyco.2015.02.005
Shafiepour M, Kiani A, Taghavi K, Seifi S, Rezaie MS, Hashemian SMR, et al. A Rare Report of Lung Metastasis of the Common Non-Melanotic Skin Cancer. Tanaffos. 2018; 17(1):62-65. PMid:30116282 PMCid:PMC6087531
Masood KI, Irfan M, Masood Q, Jamil B, Rao S, Rahim M, et al. Increased Mycobacterium tuberculosis antigen-induced gene expression of interferon-gamma, tumor necrosis factor alpha and interleukin-6 in patients with diabetes. Int J Mycobacteriol. 2016; Suppl 1:S246. https://doi.org/10.1016/j.ijmyco.2016.09.001 PMid:28043584 DOI: https://doi.org/10.1016/j.ijmyco.2016.09.001
Errarhay S, Hmidani N, Fatmi H, Saadi H, Bouchikhi C, Amarti A, et al. Post-menopausal endometrial tuberculosis mimicking carcinoma: An important differential diagnosis to consider. Int J Mycobacteriol. 2013; 2(2):118-20. https://doi.org/10.1016/j.ijmyco.2013.04.004 PMid:26785900 DOI: https://doi.org/10.1016/j.ijmyco.2013.04.004
Barrera L, Montes-Servin E, Barrera A, Ramirez-Tirado LA, Salinas-Parra F, Banales-Mendez JL, et al. Cytokine profile determined by data-mining analysis set into clusters of non-small-cell lung cancer patients according to prognosis. Ann Oncol. 2015; 26(2):428-35. https://doi.org/10.1093/annonc/mdu549 PMid:25467015 DOI: https://doi.org/10.1093/annonc/mdu549
Minkov P, Gulubova M, Chilingirov P, Ananiev J. The Position of Neutrophils-To-Lymphocytes and Lymphocytes-To-Platelets Ratio as Predictive Markers of Progression and Prognosis in Patients with Non-Small Cell Lung Cancer. Open Access Maced J Med Sci. 2018; 6(8):1382-1386. https://doi.org/10.3889/oamjms.2018.210 DOI: https://doi.org/10.3889/oamjms.2018.210
Shi J, Yuan M, Liu S, Duan X, Chen J. Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population. Tumour Biol. 2016; 37(5):6875-9. https://doi.org/10.1007/s13277-015-4512-x PMid:26662568 DOI: https://doi.org/10.1007/s13277-015-4512-x
Hunter CA, Kastelein R. Interleukin-27: balancing protective and pathological immunity. Immunity. 2012; 37(6):960-9. https://doi.org/10.1016/j.immuni.2012.11.003 PMid:23244718 PMCid:PMC3531794 DOI: https://doi.org/10.1016/j.immuni.2012.11.003
Naumnik W, Naumnik B, Niewiarowska K, Ossolinska M, Chyczewska E. Novel cytokines: IL-27, IL-29, IL-31 and IL-33. Can they be useful in clinical practice at the time diagnosis of lung cancer? Exp Oncol. 2012; 34(4):348-53. PMid:23302994
Duan M, Ning Z, Fu Z, Zhang J, Liu G, Wei Q, et al. Decreased IL-27 Negatively Correlated with Th17 Cells in Non-Small-Cell Lung Cancer Patients. Mediators Inflamm. 2015; 2015:802939. https://doi.org/10.1155/2015/802939 PMid:25969628 PMCid:PMC4417605 DOI: https://doi.org/10.1155/2015/802939
Karlicic V, Vukovic J, Stanojevic I, Sotirovic J, Peric A, Jovic M, et al. IL-27 Concentration in Systemic Circulation and Tumor Micro-Circulation Samples of Sclc and Nsclc Patients; Association with Tumor Size, Histological Type and Presence of Metastases. Austin J Clin Immunol. 2016; 3(1):1030.
Friedman A, Liao KL. The role of the cytokines IL-27 and IL-35 in cancer. Math Biosci Eng. 2015; 12(6):1203-17. https://doi.org/10.3934/mbe.2015.12.1203 PMid:26775857 DOI: https://doi.org/10.3934/mbe.2015.12.1203
Cancer Genome Atlas Research N. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012; 489(7417):519-25. https://doi.org/10.1038/nature11404 PMid:22960745 PMCid:PMC3466113 DOI: https://doi.org/10.1038/nature11404
Singletary SE, Allred C, Ashley P, et al. Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual. Surg Clin North Am. 2003; 83(4):803-19. https://doi.org/10.1016/S0039-6109(03)00034-3 DOI: https://doi.org/10.1016/S0039-6109(03)00034-3
Zhang M, Tan X, Huang J, Ke Z, Ge Y, Xiong H, et al. Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies. Med Sci Monit. 2015; 21(25):05-13. https://doi.org/10.12659/MSM.895032 DOI: https://doi.org/10.12659/MSM.895032
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Copyright (c) 2019 Akbar Soleimani Babadi, Arda Kiani, Esmaeil Mortaz, Kimia Taghavi, Adnan Khosravi, Majid Marjani, Sharareh Seifi, Habib Emami, Atefeh Abedini
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