Effect of Early Breast Milk Nutrition on Serum Insulin-Like Growth Factor-1 in Preterm Infants

Fatma A. Alzaree; Mones M. AbuShady; Mohamed Abdel Atti; Gihan A. Fathy; Essam M. Galal; Alaa Ali; Tahany R. Elias

doi:10.3889/oamjms.2019.035

Authors

Fatma A. Alzaree Department of Child Health, National Research Centre, Cairo, Egypt
Mones M. AbuShady Department of Child Health, National Research Centre, Cairo, Egypt
Mohamed Abdel Atti Department of Child Health, National Research Centre, Cairo, Egypt
Gihan A. Fathy Department of Child Health, National Research Centre, Cairo, Egypt
Essam M. Galal Department of Child Health, National Research Centre, Cairo, Egypt
Alaa Ali Department of Child Health, National Research Centre, Cairo, Egypt
Tahany R. Elias Department of Medical Biochemistry, Medical Research Division, National Research Centre, Cairo, Egypt

DOI:

https://doi.org/10.3889/oamjms.2019.035

Keywords:

Breastfeeding, Growth, IGF-1, Premature infants

Abstract

BACKGROUND: Insulin-like growth factor 1 (IGF-1) is one of the essential intrauterine hormonal mediators of growth, and its serum values are often low after preterm delivery.

AIM: To evaluate the influence of immediate breast milk feeding on serum IGF-1 in preterm newborns.

SUBJECTS AND METHODS: This prospective, observational cohort study included 60 premature infants born < 32 weeks of gestation, divided into group A and B regarding breastfeeding or formula feeding. Growth measurements were taken at birth. The standard deviation of each measurement was calculated. Serum IGF-I was measured one day postnatal and at a time equivalent to 40 weeks of gestation.

RESULTS: Significant higher level of mean serum IGF-1 was detected in group A than B at postnatal age equivalent to 40 weeks of gestation. In group A, the higher significant level was detected in mean serum IGF-1 at an age equivalent to 40 weeks of gestation than at birth (25.21 Â± 6.69 and 20.13 Â± 5.46 p < 0.05). Multiple linear regression analysis showed that high birth weight, increased age of gestation and breastfeeding were correlated to the elevated serum level of IGF-1 at a postnatal age corresponding to 40 weeks gestational age.

CONCLUSION: Immediate breast milk feeding was accompanied by elevated IGF-1 in the serum of preterm infants.

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