Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients

Thuong Nguyen Van; Lan Duong Thi; Hao Nguyen Trong; Tro Chau Van; Trang Trinh Minh; Phuong Pham Thi Minh; Nghi Dinh Huu; Van Tran Cam; My Le Huyen; Khang Tran Hau; Marco Gandolfi; Francesca Satolli; Claudio Feliciani; Michael Tirant; Aleksandra Vojvodic; Torello Lotti

doi:10.3889/oamjms.2019.054

Authors

Thuong Nguyen Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
Lan Duong Thi National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Hao Nguyen Trong Dermatology and Venereology Hospital of Ho Chi Minh City, Ho Chi Minh City, Vietnam
Tro Chau Van Pham Ngoc Thach Medical University of Ho Chi Minh City, Ho Chi Minh City, Vietnam
Trang Trinh Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Phuong Pham Thi Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Nghi Dinh Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
Van Tran Cam National Hospital of Dermatology and Venereology, Hanoi, Vietnam
My Le Huyen National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Khang Tran Hau National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
Marco Gandolfi Unit of Dermatology, University of Parma, Parma, Italy
Francesca Satolli Unit of Dermatology, University of Parma, Parma, Italy
Claudio Feliciani Unit of Dermatology, University of Parma, Parma, Italy
Michael Tirant University of Rome G. Marconi, Rome, Italy; Psoriasis Eczema Clinic, Melbourne, Australia
Aleksandra Vojvodic Department of Dermatology and Venereology, Military Medical Academy of Belgrade, Belgrade, Serbia
Torello Lotti University of Rome G. Marconi, Rome, Italy

DOI:

https://doi.org/10.3889/oamjms.2019.054

Keywords:

Common acne, Isotretinoin, Desloratadine

Abstract

AIM: To evaluate the efficacy of oral isotretinoin used alone and in combination with desloratadine in the treatment of moderate acne vulgaris.

METHODS: A comparative clinical trial was undertaken to evaluate the efficacy of oral isotretinoin alone and in combination with desloratadine in the treatment of 62 moderate acne vulgaris patients. Patients were randomised into two groups with 31 patients in each group. Each studied group's patient took 20 mg isotretinoin and 5 mg desloratadine per day. In the control group, patients took only 20 mg isotretinoin per day. The treatment time was 16 weeks. The evaluation and follow-up were done at week 2, 4, 8, 12 and 16 of the treatment.

RESULTS: The studied group had a better curative rate than the control group (45.2% versus 22.6%). The average number of inflammatory lesions in the studied group was significantly lower than the control group (0.19 versus 0.94). The mean GAGS score of the studied group was significantly lower than the control group (3.71 versus 6.52). Acne outbreaks rate of the studied group was lower than the control group (in week 2: 22.6% versus 45.2% and in week 4: 16.1% versus 38.7%, respectively). The rate of itchy was lower in the studied group.

CONCLUSION: In the treatment of moderate acne vulgaris, oral isotretinoin in combination with desloratadine is more effective and has fewer side effects than using isotretinoin alone.