The Effectiveness of Narrow Band Uvb (Nb-Uvb) In the Treatment of Pityriasis Lichenoides Chronica (PLC) In Vietnam

Doanh Le Huu; Thao Ngo Minh; Thuong Nguyen Van; Phuong Pham Thi Minh; Nghi Dinh Huu; Van Tran Cam; My Le Huyen; Minh Vu Nguyet; Mai Le Thi; Hien Do Thi Thu; Khang Tran Hau; Marco Gandolfi; Francesca Satolli; Claudio Feliciani; Michael Tirant; Aleksandra Vojvodic; Torello Lotti

doi:10.3889/oamjms.2019.055

Authors

Doanh Le Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
Thao Ngo Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Thuong Nguyen Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
Phuong Pham Thi Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Nghi Dinh Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
Van Tran Cam National Hospital of Dermatology and Venereology, Hanoi, Vietnam
My Le Huyen National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Minh Vu Nguyet National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
Mai Le Thi National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Hien Do Thi Thu National Hospital of Dermatology and Venereology, Hanoi, Vietnam
Khang Tran Hau National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
Marco Gandolfi Unit of Dermatology, University of Parma, Parma, Italy
Francesca Satolli Unit of Dermatology, University of Parma, Parma, Italy
Claudio Feliciani Unit of Dermatology, University of Parma, Parma, Italy
Michael Tirant University of Rome G. Marconi, Rome, Italy; Psoriasis Eczema Clinic, Melbourne, Australia
Aleksandra Vojvodic Department of Dermatology and Venereology Military Medical Academy, Belgrade, Serbia
Torello Lotti University of Rome G. Marconi, Rome, Italy

DOI:

https://doi.org/10.3889/oamjms.2019.055

Keywords:

Phototherapy, NB-UVB, Pityriasis lichenoides chronica, Effectiveness, Safety

Abstract

AIM: This prospective clinical study presents the experiences with NB-UVB monotherapy in the treatment of PLC on Vietnamese patients.

METHODS: We enrolled at National Hospital of Dermatology and Venereology (NHDV), Vietnam, 29 PLC patients with generalised disease involving at least 60% of the total body surface (based on Nineâ€™s Rule) and/or failed to respond to other modalities of treatment. Patients were treated with NB-UVB followed the guideline of the psoriatic treatment of AAD-2010, three times weekly.

RESULTS: A complete response (CR) was seen in 24 out of 29 PLC patients (82.8%) with a mean cumulative dose of 9760.5 mJ/cm² after a mean treatment period of 4.6 weeks (13.8 Â± 7.4 exposures). Mild side effects were observed: 69% erythema minimum, 55.2% irritation related to dry skin. No severe side effects were seen during the study. No relapses occurred in 24 CR patients within a mean period of 3 months after the last treatment.

CONCLUSION: NB-UVB therapy is an effective and safe option for the treatment and management of PLC.