Efficacy of Narrow - Band UVB Phototherapy versus PUVA Chemophototherapy for Psoriasis in Vietnamese Patients

Authors

  • Thuong Nguyen Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
  • Tam Hoang Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
  • Phuong Pham Thi Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Hao Nguyen Trong HCMC Hospital of Dermato-Venereology, Ho Chi Minh City, Vietnam
  • Tro Chau Van Department of Dermatology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam
  • Nghi Dinh Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
  • Thao Pham Thi National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Hien Do Thi Thu National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Van Tran Cam National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • My Le Huyen National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Khang Tran Hau National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Vietnam
  • Marco Gandolfi Unit of Dermatology, University of Parma, Parma, Italy
  • Francesca Satolli Unit of Dermatology, University of Parma, Parma, Italy
  • Claudio Feliciani Unit of Dermatology, University of Parma, Parma, Italy
  • Michael Tirant University of Rome G. Marconi, Rome, Italy; Psoriasis Eczema Clinic, Melbourne, Australia
  • Aleksandra Vojvodic Department of Dermatology and Venereology Military Medical Academy, Belgrade, Serbia
  • Torello Lotti University of Rome G. Marconi, Rome, Italy

DOI:

https://doi.org/10.3889/oamjms.2019.057

Keywords:

Narrow-band UVB, PUVA, Phototherapy, Chemophototherapy, Psoriasis

Abstract

BACKGROUND: Psoralen UVA (PUVA) and narrow-band UVB (NBUVB) chemophototherapy are treatment options for psoriasis.

AIM: To compare the effectiveness of NBUVB with PUVA in Vietnamese psoriasis patients.

METHODS: We conducted a non-randomized trial on 60 patients with plaque-type psoriasis (30 NBUVB, 30 PUVA). Both regimens were thrice-weekly. The extent of lesion was assessed by the Psoriasis Area Severity Index (PASI). Clearance was defined as a ≥ 75% reduction in a follow-up PASI score from baseline. Patients with clearance were followed-up until 6 months after stopping treatment. Relapse was defined as 50% or more of the original extent.

RESULTS: The proportion of patients achieving PASI75 was comparable (76.7% in NBUVB versus 80% in PUVA; p > 0.05). Patients in both groups had a similar number of sessions to achieve clearance but patients in the PUVA group exposed to a significantly higher cumulative UV dose. After six months, the relapse rate was higher in the NBUVB group compared with in the PUVA group (p > 0.05).

CONCLUSION: Thrice weekly NBUVB is as effective as thrice weekly PUVA in treating psoriasis for Vietnamese patients.

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Published

2019-01-25

How to Cite

1.
Van TN, Hoang Van T, Thi Minh PP, Nguyen Trong H, Chau Van T, Dinh Huu N, Pham Thi T, Thi Thu HD, Cam VT, Le Huyen M, Tran Hau K, Gandolfi M, Satolli F, Feliciani C, Tirant M, Vojvodic A, Lotti T. Efficacy of Narrow - Band UVB Phototherapy versus PUVA Chemophototherapy for Psoriasis in Vietnamese Patients. Open Access Maced J Med Sci [Internet]. 2019 Jan. 25 [cited 2022 May 27];7(2):227-30. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.057

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