The Decline of PUVA Therapy in Vietnam: Effective Treatment of Narrow Band UVB in Vietnamese Vitiligo Patients

Authors

  • Hien Do Thi Thu National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Nhung Do Thi Hong Hong Ngoc General Hospital, Vietnam
  • Thuong Nguyen Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Phuong Pham Thi Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Tam Hoang Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Nghi Dinh Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Hao Nguyen Trong HCMC Hospital of Dermato-Venereology, Ho Chi Minh City, Vietnam
  • Tro Chau Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Trai Nguyen Ngoc National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Khang Tran Hau National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Marco Gandolfi Unit of Dermatology, University of Parma, Parma, Italy
  • Francesca Satolli Unit of Dermatology, University of Parma, Parma, Italy
  • Claudio Feliciani Unit of Dermatology, University of Parma, Parma, Italy
  • Michael Tirant University of Rome G. Marconi, Rome, Italy; Psoriasis Eczema Clinic, Melbourne, Australia
  • Aleksandra Vojvodic Department of Dermatology and Venereology, Military Medical Academy of Belgrade, Belgrade, Serbia
  • Torello Lotti University of Rome G. Marconi, Rome, Italy

DOI:

https://doi.org/10.3889/oamjms.2019.068

Keywords:

Vitiligo, NB-UVB, PUVA, phototherapy

Abstract

AIM: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients.

METHODS: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm2 and 150 mJ/cm2, respectively, with 50 mJ/cm2 and 20 mJ/cm2 dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months. Response to therapy was assessed based on VASI score changes.

RESULTS: Based upon our results, 38.7% (12/31) of patients achieved a very good response of more than 50% VASI changes, 41.9% (13/31) obtained a good response (VASI changed from 25 to 50%). Total good and very good response to therapy significantly increased with prolonged treatment, increasing from 19.4% to 64.5% and 80.6% after 2, 4 and 6 months, respectively. Localised NSV patients obtained good and very good response significantly more frequently than generalised NSV (55.6% versus 18.2%). Adverse effects were minimal, of which one case developed herpes simplex, and 4 cases reported mild photo burn reaction which completely disappeared after adjusting the dose.

CONCLUSION: NB-UVB therapy is an effective and safe tool in the management of Vietnamese vitiligo patients.

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Published

2019-01-28

How to Cite

1.
Thi Thu HD, Thi Hong ND, Nguyen Van T, Thi Minh PP, Hoang Van T, Dinh Huu N, Nguyen Trong H, Chau Van T, Nguyen Ngoc T, Tran Hau K, Gandolfi M, Satolli F, Feliciani C, Tirant M, Vojvodic A, Lotti T. The Decline of PUVA Therapy in Vietnam: Effective Treatment of Narrow Band UVB in Vietnamese Vitiligo Patients. Open Access Maced J Med Sci [Internet]. 2019 Jan. 28 [cited 2022 May 27];7(2):256-8. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.068

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