The Decline of PUVA Therapy in Vietnam: Effective Treatment of Narrow Band UVB in Vietnamese Vitiligo Patients
DOI:
https://doi.org/10.3889/oamjms.2019.068Keywords:
Vitiligo, NB-UVB, PUVA, phototherapyAbstract
AIM: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients.
METHODS: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm2 and 150 mJ/cm2, respectively, with 50 mJ/cm2 and 20 mJ/cm2 dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months. Response to therapy was assessed based on VASI score changes.
RESULTS: Based upon our results, 38.7% (12/31) of patients achieved a very good response of more than 50% VASI changes, 41.9% (13/31) obtained a good response (VASI changed from 25 to 50%). Total good and very good response to therapy significantly increased with prolonged treatment, increasing from 19.4% to 64.5% and 80.6% after 2, 4 and 6 months, respectively. Localised NSV patients obtained good and very good response significantly more frequently than generalised NSV (55.6% versus 18.2%). Adverse effects were minimal, of which one case developed herpes simplex, and 4 cases reported mild photo burn reaction which completely disappeared after adjusting the dose.
CONCLUSION: NB-UVB therapy is an effective and safe tool in the management of Vietnamese vitiligo patients.
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Valle Y, Korobko I, Sigova J, et al. Patientâ€reported outcomes: A 5â€year long study reveals previously unreported therapeutic, demographic, socioâ€economic, and other correlations in vitiligo. Dermatologic Therapy. 2018; 31:e12620. https://doi.org/10.1111/dth.12620 PMid:30253018 DOI: https://doi.org/10.1111/dth.12620
Taïeb A, Meurant JM. Should we prioritise psychological interventions in the management of vitiligo?. Journal of the European Academy of Dermatology and Venereology. 2018; 32(12):2053-4. https://doi.org/10.1111/jdv.15297 PMid:30488996 DOI: https://doi.org/10.1111/jdv.15297
Gianfaldoni S, Tchernev G, Lotti J, Wollina U, Satolli F, Rovesti M, França K, Lotti T. Unconventional Treatments for Vitiligo: Are They (Un) Satisfactory?. Open access Macedonian journal of medical sciences. 2018; 6(1):170. https://doi.org/10.3889/oamjms.2018.038 PMid:29484020 PMCid:PMC5816295 DOI: https://doi.org/10.3889/oamjms.2018.038
Lee BW, Schwartz RA, Hercogová J, Valle Y, Lotti TM. Dermatologic therapy supplement devoted to vitiligo. Dermatol Ther. 2012; 25:S44-S56. https://doi.org/10.1111/dth.12006 PMid:23237038 DOI: https://doi.org/10.1111/dth.12006
Tawfik YM, Abd Elazim NE, Abdelâ€Motaleb AA, Mohammed RAA, Tohamy AMA. The effect of NBâ€UVB on noncultured melanocyte and keratinocyte transplantation in treatment of generalized vitiligo using two different donorâ€toâ€recipient ratios. J Cosmet Dermatol. 2018; 00:1â€9. https://doi.org/10.1111/jocd.12759 DOI: https://doi.org/10.1111/jocd.12759
Sehrawat M, Arora TC, Chauhan A, Kar HK, Poonia A, Jairath V. Correlation of Vitamin D Levels with Pigmentation in Vitiligo Patients Treated with NBUVB Therapy. ISRN Dermatol. 2014; 2014:493213. https://doi.org/10.1155/2014/493213 PMid:25006488 PMCid:PMC4005019 DOI: https://doi.org/10.1155/2014/493213
Arca E, TaÅŸtan HB, Erbil AH, Sezer E, Koc E, Kurumlu Z. Narrowâ€band ultraviolet B as monotherapy and in combination with topical calcipotriol in the treatment of vitiligo. The Journal of dermatology. 2006; 33(5):338-43. https://doi.org/10.1111/j.1346-8138.2006.00079.x PMid:16700666 DOI: https://doi.org/10.1111/j.1346-8138.2006.00079.x
Anbar TS, Westerhof W, Abdelâ€Rahman AT, Elâ€Khayyat MA. Evaluation of the effects of NBâ€UVB in both segmental and nonâ€segmental vitiligo affecting different body sites. Photodermatology, photoimmunology & photomedicine. 2006; 22(3):157-63. https://doi.org/10.1111/j.1600-0781.2006.00222.x PMid:16719871 DOI: https://doi.org/10.1111/j.1600-0781.2006.00222.x
Kumar YH, Rao GR, Gopal KV, Shanti G, Rao KV. Evaluation of narrow-band UVB phototherapy in 150 patients with vitiligo. Indian Journal of Dermatology, Venereology, and Leprology. 2009; 75(2):162. https://doi.org/10.4103/0378-6323.48662 DOI: https://doi.org/10.4103/0378-6323.48662
Majid I. Efficacy of targeted narrowband ultraviolet B therapy in vitiligo. Indian journal of dermatology. 2014; 59(5):485. https://doi.org/10.4103/0019-5154.139892 PMid:25284856 PMCid:PMC4171919 DOI: https://doi.org/10.4103/0019-5154.139892
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Hien Do Thi Thu, Nhung Do Thi Hong, Thuong Nguyen Van, Phuong Pham Thi Minh, Tam Hoang Van, Nghi Dinh Huu, Hao Nguyen Trong, Tro Chau Van, Trai Nguyen Ngoc, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
