Efficacy of BAFF in Monitoring Treatment Response in Early Vietnamese Systemic Sclerosis Patients

Authors

  • Vu Nguyen Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Hanoi, Vietnam
  • Khang Tran Hau National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Hanoi, Vietnam
  • Matushita Takashi Department of Dermatology, Kanazawa University, Kindai, Japan
  • Vinh Nguyen Ha National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Hanoi, Vietnam; Department of Dermatology, Kanazawa University, Kindai, Japan
  • Long Hoang Bao Oxford University Clinical Research Unit, Hanoi, Vietnam
  • My Le Huyen National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Doanh Le Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Hanoi, Vietnam
  • Thuong Nguyen Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam; Hanoi Medical University, Hanoi, Vietnam
  • Marco Gandolfi Unit of Dermatology, University of Parma, Parma, Italy
  • Francesca Satolli Unit of Dermatology, University of Parma, Parma, Italy
  • Claudio Feliciani Unit of Dermatology, University of Parma, Parma, Italy
  • Michael Tirant University of Rome G. Marconi, Rome, Italy; Psoriasis Eczema Clinic, Melbourne, Australia
  • Aleksandra Vojvodic Department of Dermatology and Venereology, Military Medical Academy of Belgrade, Belgrade, Serbia
  • Torello Lotti University of Rome G. Marconi, Rome, Italy

DOI:

https://doi.org/10.3889/oamjms.2019.070

Keywords:

BAFF, Systemic Sclerosis

Abstract

BACKGROUND: B-cell activating factor (BAFF) is considered to have a role in the pathogenesis of systemic sclerosis (SSc).

AIM: We conducted a longitudinal study on early SSc patients to determine the change in BAFF serum level after treatment and its association with organ involvements.

METHODS: A total of 46 patients (32 diffuse, 14 limited) were recruited, among which 35 patients (24 diffuse, 11 limited) completed 12-month follow-up.

RESULTS: Higher pretreatment BAFF levels were observed in patients with positive anti-topoisomerase antibody (ATA) (2252.1 ± 899.7 pg/ml versus 1475.5 ± 697.6 pg/ml in ATA-negative patients; p = 0.01) and muscular involvement (2741.9 ± 1039.9 pg/ml versus 1897.2 ± 762.9 pg/ml in patients without muscular involvement; p = 0.005). Lower levels were observed in patients with interstitial lung disease (ILD) (1926.7 ± 757.9 pg/ml versus 2721.6 ± 1131.4 pg/ml in non-ILD patients; p = 0.01). After treatment, BAFF level reduced significantly in diffuse SSc patients (1652.2 ± 892.7 pg/ml versus 2147.6 ± 945.5 pg/ml before treatment; p = 0.03).

CONCLUSION: Patients with worsening outcome had the highest pretreatment BAFF level and was associated with increased BAFF level after treatment. BAFF can be used to predict and monitor patients’ response to therapy.

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Published

2019-01-28

How to Cite

1.
Nguyen Minh V, Tran Hau K, Takashi M, Nguyen Ha V, Hoang Bao L, Le Huyen M, Le Huu D, Nguyen Van T, Gandolfi M, Satolli F, Feliciani C, Tirant M, Vojvodic A, Lotti T. Efficacy of BAFF in Monitoring Treatment Response in Early Vietnamese Systemic Sclerosis Patients. Open Access Maced J Med Sci [Internet]. 2019 Jan. 28 [cited 2022 May 27];7(2):264-8. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.070

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