Serum Iron Metabolism Variables in Clinically Healthy Persons


  • Mariana Penkova Department of Health care, Medical Faculty Trakia University, 11 Armeiska Street, 6000 Stara Zagora, Bulgaria
  • Nadezhda Ivanova Department of Health care, Medical Faculty Trakia University, 11 Armeiska Street, 6000 Stara Zagora, Bulgaria



Iron homeostasis, Serum ferritin, Serum iron, Transferrin saturation, Chronic liver disease


BACKGROUND: In healthy persons, iron acquisition, trafficking and storage are strictly regulated processes due to the lack of a physiological pathway for the excretion of excess iron from the body. The liver, the duodenum and the bone marrow are involved in the regulation of iron metabolism.

MATERIAL: Subject to the testing were 60 healthy volunteers who took part in clinical trials.

METHODS: Case histories, physical check-up and demographic data including people’s heights and weights, laboratory studies and tests using medical equipment.

RESULTS: None of the healthy persons were reported to have shown any deviation from the reference values for the serum markers of iron metabolism tested with the exception of hepcidin.

CONCLUSION: In healthy persons, there was only a positive correlation between iron level and IBC, and feedback between hepcidin serum levels and transferrin saturation.


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How to Cite

Penkova M, Ivanova N. Serum Iron Metabolism Variables in Clinically Healthy Persons. Open Access Maced J Med Sci [Internet]. 2019 Feb. 7 [cited 2023 Dec. 1];7(3):318-21. Available from:



A - Basic Science