Serum Iron Metabolism Variables in Clinically Healthy Persons
Keywords:Iron homeostasis, Serum ferritin, Serum iron, Transferrin saturation, Chronic liver disease
BACKGROUND: In healthy persons, iron acquisition, trafficking and storage are strictly regulated processes due to the lack of a physiological pathway for the excretion of excess iron from the body. The liver, the duodenum and the bone marrow are involved in the regulation of iron metabolism.
MATERIAL: Subject to the testing were 60 healthy volunteers who took part in clinical trials.
METHODS: Case histories, physical check-up and demographic data including peopleâ€™s heights and weights, laboratory studies and tests using medical equipment.
RESULTS: None of the healthy persons were reported to have shown any deviation from the reference values for the serum markers of iron metabolism tested with the exception of hepcidin.
CONCLUSION: In healthy persons, there was only a positive correlation between iron level and IBC, and feedback between hepcidin serum levels and transferrin saturation.
Plum Analytics Artifact Widget Block
Kaplan J, O'Halloran TV. Iron metabolism in eukaryotes: Mars and Venus at it again. Science. 1996; 271:1510-1512. https://doi.org/10.1126/science.271.5255.1510 PMid:8599104 DOI: https://doi.org/10.1126/science.271.5255.1510
Knutson M, Wessling-Resnick M. Iron metabolism in the reticuloendothelial system. Crit Rev Biochem Mol Biol. 2003; 38:61-88. https://doi.org/10.1080/713609210 PMid:12641343 DOI: https://doi.org/10.1080/713609210
Antonov K. Chronic viral hepatitis. Current state and prospects. Medinfo. 2007; 7(11): 30-32.
Gastroenterology and Hepatology, edited by Prof. Z. Krastev and Prof. K. Chernev (add year of publication).
Adzharov D, Petkova G, Koseva O. Iron as a pathogenetic factor in chronic HCV infection. Bulgarian Hepatogastroenterology. 2005; 2:33-37.
Grigorov N. Abdominal Echography in the Gastroenterology Manual. Diagnostics in a row. L Dinkov, S Stoynov. PIKS Ltd., Sofia, 1997:279-290.
Liu Z, Qiao J, Nagy T, Xiong MP. ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo. J Control Release. 2018; 283:84-93. https://doi.org/10.1016/j.jconrel.2018.05.025 PMid:29792889 DOI: https://doi.org/10.1016/j.jconrel.2018.05.025
Pietrangelo A. Pathogens, Metabolic Adaptation, and Human Diseasesâ€“An Iron-Thrifty Genetic Model. Gastroenterology. 2015; 149(4):834â€“838. https://doi.org/10.1053/j.gastro.2015.08.003 PMid:26291901 DOI: https://doi.org/10.1053/j.gastro.2015.08.003
Nai A, Lidonnici MR, Rausa M, et al. The second transferrin receptor regulates red blood cell production in mice. Blood. 2015; 125(7):1170â€“1179. https://doi.org/10.1182/blood-2014-08-596254 PMid:25499454 PMCid:PMC4399753 DOI: https://doi.org/10.1182/blood-2014-08-596254
Andrews NC, Iron metabolism: iron deficiency and iron overload, Annu Rev Genomics Hum Genet. 2000;1:75-98. https://doi.org/10.1146/annurev.genom.1.1.75 PMid:11701625 DOI: https://doi.org/10.1146/annurev.genom.1.1.75
Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306(5704):2090â€“2093. https://doi.org/10.1126/science.1104742 PMid:15514116 DOI: https://doi.org/10.1126/science.1104742
Zumerle S, Mathieu JR, Delga S, et al. Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype. Blood. 2014; 123(23):3646â€“3650. https://doi.org/10.1182/blood-2014-01-550467 PMid:24646470 DOI: https://doi.org/10.1182/blood-2014-01-550467
Wang CY, Babitt JL. Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol. 2016; 23(3):189â€“197. https://doi.org/10.1097/MOH.0000000000000236 PMid:26886082 PMCid:PMC4993159 DOI: https://doi.org/10.1097/MOH.0000000000000236
McCord JM. Iron, free radicals, and oxidative injury. Semin Hematol. 1998; 35:5-12. PMid:9460805
How to Cite
Copyright (c) 2019 Mariana Penkova, Nadezhda Ivanova
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.