Successful Treatment of Intralesional Triamcilonon Acetonide Injection in Keloid Patients

Abstract

AIM: Evaluation the effect of intralesional corticosteroid injection on keloid, at the National Hospital of Dermatology and Venereology from 1/2009 to 12/2009.

METHODS: A group of 65 patients with keloid were randomly assigned into three groups. In the studied group, 33 patients were intralesionally injected 7.5 mg/1 cm² of TCA. In the control group, TAC 32 patients were intralesionally injected 15 mg/1 cm² of TCA. The result was evaluated basing on the criteria of Henderson (1998) and El-Tonsy (1996).

RESULTS: In comparison between 2 groups, good to excellent improvement in the studied group was statistically higher than the control group (90.7% versus 68.7%; p < 0.05). After each injection, the thickness of the scar was reduced 1.24 ± 0.53 mm in the studied group and 0.81 ± 0.39 mm in the control group. The disappearance of pain and itching after treatment were 86.6% and 95.5% in the studied group and 78.1% and 80% in the control group (p > 0.05). Ulceration, acne and troublesome with menstrual cycles were sometimes were noted more frequently in the control group than in the studied group.

CONCLUSION: Intralesional triamcinolone acetonide injection had a good result, and 7.5 mg/1 cm² scar is the best dose for treatment of keloid.