Successful Treatment of Intralesional Bleomycin in Keloids of Vietnamese Population

Authors

  • Nghi Dinh Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Sau Nguyen Huu National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Xuan Le Thi National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Thuong Nguyen Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Phuong Pham Thi Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Trang Trinh Minh National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Tam Hoang Van National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Van Tran Cam National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • My Le Huyen National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Khang Tran Hau National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Marco Gandolfi Unit of Dermatology, University of Parma, Parma, Italy
  • Francesca Satolli Unit of Dermatology, University of Parma, Parma, Italy
  • Claudio Feliciani Unit of Dermatology, University of Parma, Parma, Italy
  • Michael Tirant University of Rome G. Marconi, Rome, Italy; Psoriasis Eczema Clinic, Melbourne, Australia
  • Aleksandra Vojvodic Department of Dermatology and Venereology, Military Medical Academy of Belgrade, Belgrade, Serbia
  • Torello Lotti University of Rome G. Marconi, Rome, Italy

DOI:

https://doi.org/10.3889/oamjms.2019.099

Keywords:

keloid, bleomycin

Abstract

BACKGROUND: Keloid is an overactive condition of the skin tissue to early lesions characterised by proliferation of fibroblasts, excessive collagen production in the lesion. Treatment of keloids is a big challenge because of the poor response rate and high risk of recurrence after treatment. We found that bleomycin offers promise in the treatment of keloids.

AIM: To evaluate the efficacy of bleomycin injected in the injury for keloids treatment.

METHODS: The treatment was carried out in 55 patients having 120 keloids of different sizes and locations. Average treatments were 4 times.

RESULTS: Complete flattening was 70.8%, highly significant flattening was 8.3%, no patient of minimal flattening. Systemic side-effects of bleomycin were not evaluated, but local side-effects were mainly pains (100%), blisters (78.3%), ulceration (5.8%), and hyperpigmentation (56.7%).

CONCLUSION: The percentage of patients recurring 6, 12, 15, 18 months after the last treatment were 3.8, 15.4, 45.5, 50%, respectively.

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Published

2019-01-29

How to Cite

1.
Dinh Huu N, Nguyen Huu S, Le Thi X, Nguyen Van T, Thi Minh PP, Trinh Minh T, Hoang Van T, Cam VT, Le Huyen M, Tran Hau K, Gandolfi M, Satolli F, Feliciani C, Tirant M, Vojvodic A, Lotti T. Successful Treatment of Intralesional Bleomycin in Keloids of Vietnamese Population. Open Access Maced J Med Sci [Internet]. 2019 Jan. 29 [cited 2026 Aug. 10];7(2):298-9. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.099

Issue

Vol. 7 No. 2 (2019): Jan 30 (OAMJMS) Vietnamese Dermatology

Section

B - Clinical Sciences

License

Copyright (c) 2019 Nghi Dinh Huu, Sau Nguyen Huu, Xuan Le Thi, Thuong Nguyen Van, Phuong Pham Thi Minh, Trang Trinh Minh, Tam Hoang Van, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)

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