Differences in Brain-Derived Neurotrophic Factor and Matrix Metalloproteinase-9 between Appropriate Neonates between Normal Birth Weight and Intrauterine Growth Restriction
DOI:
https://doi.org/10.3889/oamjms.2019.159Keywords:
BDNF, MMP-9, Normal birth weight, IUGRAbstract
BACKGROUND: Intrauterine Growth Restriction (IUGR) was defined as the growth of the fetus less than its normal potential growth due to genetic and environmental factors. One of the most widely believed causes of IUGR was impaired uteroplacental mechanism from mother to fetus. Furthermore, factor which was thought to affect placental growth was due to the influence of Brain-Derived Neurotrophic Factor (BDNF) and Matrix Metalloproteinase (MMP-9) which play an important role in angiogenesis.
AIM: This study aims to determine differences in Brain-Derived Neurotrophic Factor (BDNF) and moderately mature Matrix Metalloproteinase (MMP-9) between normal birth weight and intrauterine growth restriction.
MATERIAL AND METHODS: The study design was a cross-sectional study at four hospitals in Padang city from August 2017-January 2018. The sample of this study was umbilical cord blood of appropriate gestational age neonate with normal birth weight (31 neonates) and IUGR (31 neonates) by consecutive sampling, samples taken from mothers who meet inclusion criteria. BDNF and MMP-9 levels were analysed by ELISA. The differences between normal birth weight and IUGR test were followed by unpaired T-test.
RESULTS: The results showed that BDNF levels in normal neonates was 1.58 ± 0.23 ng/ml and in IUGR neonates were 1.25 ± 0.35 ng/ml (p = 0.001). MMP-9 levels in normal neonates was 1.09 ± 0.20 ng/ml and in IUGR neonates were 1.25 ± 0.35 (p = 0.03).
CONCLUSION: The conclusion of this study was BDNF of moderately mature neonates was significantly higher in normal birth weight compared to intrauterine growth restriction, and the moderately high MMP-9 neonates were significantly higher in intrauterine growth restriction compared with normal birth weight.
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Kliegman RM, Nelson WE. Nelson Textbook of PEdiatrics 20th Edition. Philadelphia. Elsevier, 2016.
Murki S, Sharma D. Intrauterine Growth Retardation. A Review Article, Neonatal Biology. 3, 2016.
Kosim MS, Yunanto A, Dewi R, Sarosa GI, Usman A. Buku Ajar Neonatologi Edisi Pertama. Jakarta. Ikatan Dokter Anak Indonesia, 2008.
Sadler TW. Langman's Medical Embryology 13th Edition. Philadelphia. Wolters Kluwer Health, 2015.
Sahay AS, Sundrani DP, Joshi SR. Regional Changes of Placental Vascularization in Preeclampsia. A Review, International Union of Biochemistry and Molecular Biology. 2015; 67:619-625. https://doi.org/10.1002/iub.1407 PMid:26269153
Plaks V, inkenberger J, Dai J, Flannery M, Sund M, Kanasaki K. Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. PNAS. 2013; 1109-11114.
Hauser SL. Neurology in Clinical Medicine. Unite Stated. Mc Graw Hill ucationE, 2013.
Mayeur S, Silhol M, Moitrot E, Barbaux S, Breton C, Gabory A, Vaiman D, Dutriez-Casteloot I, Fajardy I, Vambergue A, Tapia-Arancibia L. Placental BDNF/TrkB signaling system is modulated by fetal growth disturbances in rat and human. Placenta. 2010; 31(9):785-91. https://doi.org/10.1016/j.placenta.2010.06.008 PMid:20615547
Nakamura K, Martin KC, Jackson JK, Beppu K, Woo CW, Thiele CJ. Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1α in neuroblastoma cells. Cancer research. 2006; 66(8):4249-55. https://doi.org/10.1158/0008-5472.CAN-05-2789 PMid:16618748
Fung J, Gelaye B, Zhong QY, Rondon MB, Sanchez SE, Barrios YV, Hevner K, Qiu C, Williams MA. Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression. BMC psychiatry. 2015; 15(1):43. https://doi.org/10.1186/s12888-015-0428-7 PMid:25886523 PMCid:PMC4364091
Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, Virchow JC. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiology of aging. 2005; 26(1):115-23. https://doi.org/10.1016/j.neurobiolaging.2004.03.002 PMid:15585351
Gustuti R, Indrawati LN, Machmud R. Differences in brain-derived neurotrophic factor between neonates born to mothers with normal and low ferritin. Asia Pacific journal of clinical nutrition. 2018; 27(2):389.
Sastroasmoro S, Ismael S. 2014. Dasar-dasar Metodologi Klinis. Jakarta, Sagung Seto. PMCid:PMC4153860
Bienertova-Vasku J, Bienert P, Zlamal F, Splichal Z, Tomandl J, Tomandlova M, Hodicka Z, Ventruba P, Vasku A. Brain-derived neurotrophic factor and ciliary neurotrophic factor in maternal plasma and umbilical cord blood from pre-eclamptic and physiological pregnancies. Journal of Obstetrics and Gynaecology. 2013; 33(4):359-63. https://doi.org/10.3109/01443615.2013.776026 PMid:23654315
Lee C, An J, Kim JH, Kim ES, Kim SH, Cho YK, Cha DH, Han MY, Lee KH, Sheen YH. Low levels of tissue inhibitor of metalloproteinase-2 at birth may be associated with subsequent development of bronchopulmonary dysplasia in preterm infants. Korean journal of pediatrics. 2015; 58(11):415. https://doi.org/10.3345/kjp.2015.58.11.415 PMid:26692876 PMCid:PMC4675921
Christian LM, Mitchell AM, Gillespie SL, Palettas M. Serum brain-derived neurotrophic factor (BDNF) across pregnancy and postpartum: associations with race, depressive symptoms, and low birth weight. Psychoneuroendocrinology. 2016; 74:69-76. https://doi.org/10.1016/j.psyneuen.2016.08.025 PMid:27588702 PMCid:PMC5166606
Kawamura K, Kawamura N, Fukuda J, Kumagai J, Hsueh AJ, Tanaka T. Regulation of preimplantation embryo development by brain-derived neurotrophic factor. Developmental biology. 2007; 311(1):147-58. https://doi.org/10.1016/j.ydbio.2007.08.026 PMid:17880937
Dhobale M. Neurotrophins: role in adverse pregnancy outcome. International Journal of Developmental Neuroscience. 2014; 37:8-14. https://doi.org/10.1016/j.ijdevneu.2014.06.005 PMid:24953262
Malamitsiâ€Puchner AR, Nikolaou KE, Puchner KP. Intrauterine growth restriction, brainâ€sparing effect, and neurotrophins. Annals of the New York Academy of Sciences. 2006; 1092(1):293-6. https://doi.org/10.1196/annals.1365.026 PMid:17308153
Merchant SJ, Crocker IP, Baker PN, Tansinda D, Davidge ST, Guilberg LJ. Matrix metalloproteinase release from placental explants of pregnancies complicated by intrauterine growth restriction. Journal of the Society for Gynecologic Investigation. 2004; 11(2):97-103. https://doi.org/10.1016/j.jsgi.2003.08.005 PMid:14980311
Laskowska M. Altered maternal serum matrix metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in severe early-and late-onset preeclampsia. BioMed research international. 2017; 2017.
Cederqvist K, Sorsa T, Tervahartiala T, Maisi P, Reunanen K, Lassus P, Andersson S. Matrix metalloproteinases-2,-8, and-9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress. Pediatrics. 2001; 108(3):686-92. https://doi.org/10.1542/peds.108.3.686 PMid:11533337
Sagi I, Gaffney J, editors. Matrix metalloproteinase biology. John Wiley & Sons; 2015. https://doi.org/10.1002/9781118772287
Wei L. Mata KM, Mazzuca MQ & Khalil, RA. Altered Matrix Metalloproteinase-2 and -9 Expression/Activity Links Placental Ischemia and Anti-angiogenic sFlt-1 to Uteroplacental and Vascular Remodeling and Collagen Deposition in Hypertensive Pregnancy. Biochem Pharmacol. 2014; 89(3):370-385. https://doi.org/10.1016/j.bcp.2014.03.017 PMid:24704473 PMCid:PMC4034157
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