The Determinants of Salivary Cotinine Concentration in Smokeless Tobacco Users
DOI:
https://doi.org/10.3889/oamjms.2019.174Keywords:
Salivary Cotinine, Smokeless Tobacco, TradesmenAbstract
BACKGROUND: Smokeless tobacco products due to their high nicotine content are highly addictive and ultimately lead to an increased risk of oral cavity, laryngeal and oesophagal cancer.
AIM: This research was conducted with the aim of assessing the relationship between the salivary cotinine concentration and demographic characteristics and smokeless tobacco use for the first time in tradespeople in Chabahar, Iran.
METHODS: This descriptive cross-sectional study was conducted on 150 different tradespeople using smokeless tobacco in Chabahar who were selected through simple random sampling in 2018. In addition to the salivary cotinine measurement, data were collected using a researcher-made questionnaire with demographic and behavioural items. The data obtained were analysed in SPSS-16 using descriptive and inferential statistics.
RESULTS: The mean salivary cotinine score was 887.7 ± 180.7 in men and 611.2 ± 139.7 in women, making for a significant intergroup difference (P = 0.043). The mean salivary cotinine score was higher in those who used two or more smokeless tobacco products compared to those who used one type of tobacco, and a significant difference was observed between the type of smokeless tobacco used and the salivary cotinine score in the participants (P = 0.005).
CONCLUSION: Based on the results of the regression analysis, the type of smokeless tobacco used was a strong predictor of the concentration of salivary cotinine in the participants. It is, therefore, necessary for the government to adopt appropriate policies and take educational measures to reduce the vending and use of these substances.
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Khan A, Huque R, Shah SK, Kaur J, Baral S, Gupta PC et al. Smokeless tobacco control policies in South Asia: A gap analysis and recommendations. Nicotine & tobacco research: official journal of the Society for Research on Nicotine and Tobacco. 2014;16(6):890-894. https://doi.org/10.1093/ntr/ntu020 PMid:24616238
Stanfill B, Connolly GN, Zhang L, Jia LT, Henningfield JE, Richter P, et al. Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines. Tobacco Control. 2010; 20(3):e2. https://doi.org/10.1136/tc.2010.037465 PMid:21109685
Huque R, Shah S, Mushtaq N, Siddiqi K. Determinants of Salivary Cotinine among Smokeless Tobacco Users: A Cross-Sectional Survey in Bangladesh. PLoS ONE. 2016; 11(8):e0160211. https://doi.org/10.1371/journal.pone.0160211 PMid:27504912 PMCid:PMC4978394
Gajalakshmi V, Kanimozhi V. Tobacco chewing and adult mortality: a case-control analysis of 22,000 cases and 429,000 controls, never smoking tobacco and never drinking alcohol, in South India. Asian Pac J Cancer Prev. 2015; 16(3):1201-6. https://doi.org/10.7314/APJCP.2015.16.3.1201 PMid:25735356
Siddiqi K, Shah SK, Abbas SM, Vidyasagaran A, Jawad M, Dogar O, et al. Global burden of disease due to smokeless tobacco consumption in adults: Analysis of data from 113 countries. BMC Medicine. 2015; 13:194–215. https://doi.org/10.1186/s12916-015-0424-2 PMid:26278072 PMCid:PMC4538761
Rakhshani F, Sepehri ZA, Keikha M, Rakhshani T, Ebrahimi MR. Paan Use in South-Eastern Iran: The Associated Factors. Iranian Red Crescent Medical Journal. 2011;13(9):659-663. https://doi.org/10.5812/kowsar.20741804.2249
Basu R, Mandal S, Ghosh A, Poddar TK. Role of tobacco in the development of head and neck squamous cell carcinoma in an eastern Indian population. Asian Pac J Cancer Prev 2008; 9:381-6. PMid:18990006
Changrani J, Gany FM, Cruz G, Kerr R, Katz R. Paan and Gutka Use in the United States: A Pilot Study in Bangladeshi and IndianGujarati Immigrants in New York City. J Immigr Refug Stud. 2006; 4:99-110. https://doi.org/10.1300/J500v04n01_07 PMid:17492057 PMCid:PMC1867456
Honarmand MH, Farhadmollashahi L, Bekyghasemi M. Use of smokeless tobacco among male students of Zahedan universities in Iran: a cross sectional study. Asian Pacific journal of cancer prevention. 2013; 14(11):6385-8. https://doi.org/10.7314/APJCP.2013.14.11.6385 PMid:24377537
Florescu A, Ferrence R, Einarson T, Selby P, Soldin O, Koren G. Methods for Quantification of Exposure to Cigarette Smoking and Environmental Tobacco Smoke: Focus on Developmental Toxicology. Therapeutic drug monitoring. 2009; 31(1):14-30. https://doi.org/10.1097/FTD.0b013e3181957a3b PMid:19125149 PMCid:PMC3644554
Yamazaki H, Horiuchi K, Takano R, et al. Human Blood Concentrations of Cotinine, a Biomonitoring Marker for Tobacco Smoke, Extrapolated from Nicotine Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling. International Journal of Environmental Research and Public Health. 2010; 7(9):3406-3421. https://doi.org/10.3390/ijerph7093406 PMid:20948932 PMCid:PMC2954553
Benowitz NL, Hukkanen J, Jacob P. Nicotine Chemistry, Metabolism, Kinetics and Biomarkers. Handbook of experimental pharmacology. 2009; (192):29-60. https://doi.org/10.1007/978-3-540-69248-5_2 PMid:19184645 PMCid:PMC2953858
Raja M, Garg A, Yadav P, Jha K, Handa S. Diagnostic Methods for Detection of Cotinine Level in Tobacco Users: a review. Journal of Clinical and Diagnostic Research: JCDR. 2016; 10(3):4-6. https://doi.org/10.7860/JCDR/2016/17360.7423
Nuca C, Amariei C, Badea V, Zaharia A, Bucur L, Arendt C. Salivary cotinine - biomarker of tobacco consumption in the assessment of passive smoking prevalence. FARMACIA. 2012; 60(5):662–74.
Mushtaq N, Beebe LA, Vesely SK. Determinants of salivary cotinine concentrations among smokeless tobacco users. Nicotine & Tobacco Research. 2012; 14:1229–34. https://doi.org/10.1093/ntr/ntr279 PMid:22180597
Ferketich AK, Wee AG, Shultz J, Wewers ME. Smokeless Tobacco Use and Salivary Cotinine Concentration. Addictive behaviors. 2007; 32(12):2953-2962. https://doi.org/10.1016/j.addbeh.2007.06.012 PMid:17604914 PMCid:PMC2262158
Avila-Tang K, Al-Delaimy David L, Ashley Neal L, Benowitz J, Thomas Bernert K, Jonathan M, et al. Assessing secondhand smoke using biological markers. Tob Control. 2013; 22(3):164-171. https://doi.org/10.1136/tobaccocontrol-2011-050298 PMid:22940677 PMCid:PMC3639350
Kim S, Apelberg BJ, Avila-Tang E, et al. Utility and Cutoff Value of Hair Nicotine as a Biomarker of Long-Term Tobacco Smoke Exposure, Compared to Salivary Cotinine. International Journal of Environmental Research and Public Health. 2014; 11(8):8368-8382. https://doi.org/10.3390/ijerph110808368 PMid:25153466 PMCid:PMC4143866
Neal LB, Katherine E, Christine A, Alan Wu, Katherine M, Peyton J. Prevalence of Smoking Assessed Biochemically in an Urban Public Hospital: A Rationale for Routine Cotinine Screening. American Journal of Epidemiology. 2009; 170(7):885–891. https://doi.org/10.1093/aje/kwp215 PMid:19713287 PMCid:PMC2765360
Lorina R, Madi M, Bhat S. Salivary Cotinine Levels as a Biomarker of Tobacco Use-A Biochemical Study. JKIMSU, 2017; 6(4):1-9.
Asha V, Dhanya M. Immunochromatographic Assessment of Salivary Cotinine and Its Correlation with Nicotine Dependence in Tobacco Chewers. Journal of Cancer Prevention. 2015; 20(2):159-163. https://doi.org/10.15430/JCP.2015.20.2.159 PMid:26151050 PMCid:PMC4492361
Binnie V I, McHugh S, Macpherson L, Borland B, Moir K, Malik K. The validation of self-reported smoking status by analysing cotinine levels in stimulated and unstimulated saliva, serum and urine. Oral diseases. 2004; 10(5):287-93. https://doi.org/10.1111/j.1601-0825.2004.01018.x PMid:15315646
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Copyright (c) 2019 Sayed Saeed Mazloomy Mahmoodabad, Mohammad Saeed Jadgal, Iraj Zareban, Hossein Fallah Zadeh
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