The Effect of Local Pharmacological Agents in Acceleration of Orthodontic Tooth Movement: A Systematic Review
DOI:
https://doi.org/10.3889/oamjms.2019.203Keywords:
local pharmacological, accleration of tooth movementAbstract
AIM: Acceleration of orthodontic tooth movement has gained a massive interest to decrease the total treatment time. Local pharmacological agents might be used for that purpose as a practical, effective and inexpensive alternative. A systematic review was achieved to evaluate the evidence in that topic.
METHODS: A search was conducted on electronic databases including PubMed, Lilacs, Web of Science (Thompson Reuters), EMBASE (OvidSP), and Cochrane Database of Systematic Reviews (Wiley) in addition to hand searching of relevant journals till June 2018. Only studies written in English were utilised. Publications were selected, assessed systematically and graded by two observers according to Bondemark grading system.
RESULTS: Only two human studies were found investigating the effect of Relaxin and Prostaglandins in the rate of orthodontic tooth movement. No obvious side effects were reported. Relaxin showed no increase in the rate of tooth movement while prostaglandin showed a marked increase in the rate of orthodontic tooth movement.
CONCLUSION: There is below moderate evidence showing no effect of relaxin on orthodontic tooth movement, while inconclusive evidence was found regarding Prostaglandin in the acceleration of orthodontic tooth movement. More prospective well-conducted clinical trials are needed to reach a proper conclusion regarding the local pharmacological agents which can be safely used to accelerate orthodontic tooth movement.
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References
Proffit WR. Biologic basis of orthdontic therapy. In: Proffit WR, and Fields HW, editors. Contemporary Orthodontics. Mosby, Inc., 2000.
Holman JK, Hans MG, Nelson S, Powers MP. An assessment of extraction versus nonextraction orthodontic treatment using the peer assessment rating (PAR) index. The Angle Orthodontist. 1998; 68(6):527-34. PMid:9851350
Richter AE, Arruda AO, Peters MC, Sohn W. Incidence of caries lesions among patients treated with comprehensive orthodontics. American Journal of Orthodontics and Dentofacial Orthopedics. 2011; 139(5):657-64. https://doi.org/10.1016/j.ajodo.2009.06.037 PMid:21536209
Liu H, Sun J, Dong Y, Lu H, Zhou H, Hansen BF, Song X. Periodontal health and relative quantity of subgingival Porphyromonas gingivalis during orthodontic treatment. The Angle Orthodontist. 2011; 81(4):609-15. https://doi.org/10.2319/082310-352.1 PMid:21306224
Long H, Pyakurel U, Wang Y, Liao L, Zhou Y, Lai W. Interventions for accelerating orthodontic tooth movement: a systematic review. The Angle Orthodontist. 2012; 83(1):164-71. https://doi.org/10.2319/031512-224.1 PMid:22720793
Chung CJ, Baik HS, Soma K. Bone formation and tooth movement are synergistically enhanced by administration of EP4 agonist. American Journal of Orthodontics and Dentofacial Orthopedics. 2007; 132(4):13–20. https://doi.org/10.1016/j.ajodo.2007.02.049 PMid:17920491
Sekhavat AR, Mousavizadeh K, Pakshir HR, Aslani FS. Effect of misoprostol, a prostaglandin E1 analog, on orthodontic tooth movement in rats. American journal of orthodontics and dentofacial orthopedics. 2002; 122(5):542-7. https://doi.org/10.1067/mod.2002.126153 PMid:12439483
Hoogeveen EJ, Jansma J, Ren Y. Surgically facilitated orthodontic treatment: a systematic review. American Journal of Orthodontics and Dentofacial Orthopedics. 2014; 145(4):S51-64. https://doi.org/10.1016/j.ajodo.2013.11.019 PMid:24680025
Liem AML, Hoogeveen EJ, Jansma J, Ren Y. Surgically facilitated experimental movement of teeth: Systematic review. Br J Oral Maxillofac Surg. 2015; 53(6):491–506. https://doi.org/10.1016/j.bjoms.2015.03.009 PMid:25911054
Gkantidis N, Mistakidis I, Kouskoura T, Pandis N. Effectiveness of non-conventional methods for accelerated orthodontic tooth movement: A systematic review and meta-analysis. J Dent [Internet]. 2014; 42(10):1300–1319. https://doi.org/10.1016/j.jdent.2014.07.013 PMid:25072362
Moher D, Liberati, Alessandro, Tetzlaff JM, Altman DG. Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and publication bias. J Clin Epidemiol. 2009; 62:1006–1012. https://doi.org/10.1016/j.jclinepi.2009.06.005 PMid:19631508
Bondemark L, Holm a. K, Hansen K, Axelsson S, Mohlin B, Brattstrom V, Paulin G, and Pietila T. Long-term stability of orthodontic treatment and patient satisfaction. Angle Orthod [Internet]. 2007; 77(1):181–191. https://doi.org/10.2319/011006-16R.1 PMid:17029533
Wins SM, Antonarakis GS, and Kiliaridis S. Predictive factors of sagittal stability after treatment of Class II malocclusions. Angle Orthod. 2016; 86(6):1033–1041. https://doi.org/10.2319/052415-350.1 PMid:26618887
Spielmann T, Wieslander L, and Hefti AF. [Acceleration of orthodontically induced tooth movement through the local application of prostaglandin (PGE1)]. Schweiz Monatsschr Zahnmed. 1989; 99(2):162–5. PMid:2717904
Weng SE, Liu K, and Shen G. [The effect of iontophoresis on accelerating orthodontic tooth movement]. Shanghai Kou Qiang Yi Xue. 1993; 2(4):206–8. PMid:15159805
McGorray SP, Dolce C, Kramer S, Stewart D, Wheeler TT. A randomized, placebo-controlled clinical trial on the effects of recombinant human relaxin on tooth movement and short-term stability. Am J Orthod Dentofacial Orthop. 2012; 141(2):196–203. https://doi.org/10.1016/j.ajodo.2011.07.024 PMid:22284287
Yamasaki K, Shibata Y, Imai S, Tani Y, Shibasaki Y, Fukuhara T. Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement. Am J Orthod. 1984; 85(6):508–18. https://doi.org/10.1016/0002-9416(84)90091-5
Kobayashi Y, Takagi H, Sakai H, Hashimoto F, Mataki S, Kobayashi K, Kato Y. Effects of local administration of osteocalcin on experimental tooth movement. Angle Orthod. 1998; 68(3):259–266. PMid:9622763
Gonzales C, Hotokezaka H, Matsuo K-I, Shibazaki T, Yozgatian JH, Darendeliler MA, Yoshida N. Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar. Angle Orthod. 2009; 79(4):715–26. https://doi.org/10.2319/072108-381.1 PMid:19537869
Kehoe MJ, Cohen SM, Zarrinnia K, and Cowan A. The effect of acetaminophen, ibuprofen, and misoprostol on prostaglandin E2 synthesis and the degree and rate of orthodontic tooth movement, 2010. Available from: http://angle.org/doi/abs/10.1043/0003-3219%281996%29066%3C0339%3ATEOAIA%3E2.3.CO%3B2?=
Roche JJ, Cisneros GJ, and Acs G. The effect of acetaminophen on tooth movement in rabbits, 2010. Available from: http://angle.org/doi/abs/10.1043/0003-3219%281997%29067%3C0231%3ATEOAOT%3E2.3.CO%3B2?=
Sodagar A, Donyavi Z, Arab S, Kharrazifard MJ. Effect of nicotine on orthodontic tooth movement in rats. American Journal of Orthodontics and Dentofacial Orthopedics. 2011; 139(3):e261-5. https://doi.org/10.1016/j.ajodo.2010.08.018 PMid:21392670
Yi J, Xiao J, Li H, Li Y, Li X, Zhao Z. Effectiveness of adjunctive interventions for accelerating orthodontic tooth movement: a systematic review of systematic reviews. J Oral Rehabil. 2017; 44(8):636–654. https://doi.org/10.1111/joor.12509 PMid:28301678
Brudvik P, Rygh P. Root resorption after local injection of prostaglandin E2 during experimental tooth movement. Eur J Orthod [Internet]. 1991; 13(4):255–63. https://doi.org/10.1093/ejo/13.4.255
Lee WC. Experimental study of the effect of prostaglandin administration on tooth movement--with particular emphasis on the relationship to the method of PGE1 administration. Am J Orthod Dentofacial Orthop. 1990; 98(3):231–41. https://doi.org/10.1016/S0889-5406(05)81600-2
De Carlos F, Cobo J, Perillan C, Garcia MA, Arguelles J, Vijande M, and Costales M. Orthodontic tooth movement after different coxib therapies. Eur J Orthod. 2007; 29(6):596–9. https://doi.org/10.1093/ejo/cjm072 PMid:17878187
De Carlos F, Cobo J, DÃaz-Esnal B, Arguelles J, Vijande M, and Costales M. Orthodontic tooth movement after inhibition of cyclooxygenase-2. Am J Orthod Dentofacial Orthop. 2006; 129(3):402–6. https://doi.org/10.1016/j.ajodo.2005.11.020 PMid:16527637
Ribeiro JS, Maciel JVB, Knop LAH, Machado MÂN, Grégio AMT, and Camargo ES. Effect of growth hormone in experimental tooth movement. Braz Dent J. 2013; 24(5):503–7. https://doi.org/10.1590/0103-6440201302286 PMid:24474293
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Copyright (c) 2019 Ahmed Eltimamy, Fouad Aly El-Sharaby, Faten Hussien Eid, Amr Emad El-Dakrory
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