Comparison of Salivary Cortisol Level in Type 2 Diabetic Patients and Pre-Diabetics with Healthy People

Maedeh Salehi; Abbas Mesgarani; Soosan Karimipour; Shaghayegh Zahed Pasha; Zahra Kashi; Saeed Abedian; Mahmoud Mousazadeh; Tahereh Molania

doi:10.3889/oamjms.2019.340

Authors

Maedeh Salehi Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Science, Sari, Iran
Abbas Mesgarani Department of Endodontics, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
Soosan Karimipour Faculty of Dentistry, Mazandaran University of Medical Science, Sari, Iran
Shaghayegh Zahed Pasha Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Science, Sari, Iran
Zahra Kashi Department of Internal Medicine, Diabetes Research Center, Mazandaran University of Medical Science, Sari, Iran
Saeed Abedian Department of Immunology, Faculty of Medicine, Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Mahmoud Mousazadeh Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Science, Sari, Iran
Tahereh Molania Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Science, Sari, Iran

DOI:

https://doi.org/10.3889/oamjms.2019.340

Keywords:

Type 2 Diabetes, Prediabetes, Cortisol

Abstract

BACKGROUND: Cortisol is one of the important enzymes of saliva. Control of this hormone is an effective way to adjust the glucose level in diabetic patients.

AIM: The aim of this research is to compare the salivary cortisol level in type 2 diabetic patients and pre-diabetics with healthy people.

METHODS: In this case-control study (2018), the unstimulated salivary samples were collected from 44 patients with type 2 diabetes, 44 pre-diabetic people (case group), and 44 healthy subjects (control group), matched for age and gender. The samples were transferred to the laboratory, and salivary cortisol level was measured using ELISA. Data were analysed using SPSS 22 and Chi 2 tests.

RESULTS: The mean salivary cortisol level in type 2 diabetic patients was 3.14 Â± 1.17, in pre-diabetic cases was 1.83 Â± 0.68, and in healthy controls was 0.86 Â± 0.43 (P < 0.001). The mean DMFT in type 2 diabetic patients was 19.6 Â± 6.5, in the pre-diabetic group was 13.43 Â± 4.5, and in healthy controls was 9.38 Â± 3.72 (P < 0.001).

CONCLUSION: With regards to the results, salivary cortisol level in type 2 diabetic patients is more than pre-diabetic people, and in pre-diabetic people is more than healthy people. Also, there was a significant relation between salivary cortisol level and DMFT index.