Viral and Host Factors are Related to the Progression of HIV Diseases in Mimika, Papua
DOI:
https://doi.org/10.3889/oamjms.2019.437Keywords:
HIV-1 genotype, HIV/AIDS progression, MimikaAbstract
BACKGROUND: Papua has a high cumulative number of HIV, which has expanded epidemic status with the most risk factors are heterosexuals.
AIM: This study aims to determine factors associated with HIV disease progression include host and viral factors.
METHODS: Eighty-four subjects recruited in Rumah Sakit Mitra Masyarakat (RSMM) VCT’s laboratory, interviewed with questionnaires and also did laboratory examinations. HIV-1 subtypes were identified using RT-PCR, nested PCR and sequencing. Then, CD4+ data is checked using PIMA Analyzer. Demographic and clinical data obtained from the patient's medical record. After collected, data were analysed using Fisher's exact test.
RESULTS: The results showed two factors that influence the progression of HIV disease were HIV subtypes (p = 0.002) and Body Mass Index (p = 0.033). The HIV-1 subtype also correlated with CD4+ levels with a value of p = 0.04.
CONCLUSION: HIV-1 subtype correlates with HIV progression, so it is necessary to develop HIV/AIDS management strategies and clinical counselling.
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Copyright (c) 2019 Mirna Widiyanti, Moch Irfan Hadi (Author)
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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