Viral and Host Factors are Related to the Progression of HIV Diseases in Mimika, Papua

Abstract

BACKGROUND: Papua has a high cumulative number of HIV, which has expanded epidemic status with the most risk factors are heterosexuals.

AIM: This study aims to determine factors associated with HIV disease progression include host and viral factors.

METHODS: Eighty-four subjects recruited in Rumah Sakit Mitra Masyarakat (RSMM) VCT’s laboratory, interviewed with questionnaires and also did laboratory examinations. HIV-1 subtypes were identified using RT-PCR, nested PCR and sequencing. Then, CD4+ data is checked using PIMA Analyzer. Demographic and clinical data obtained from the patient's medical record. After collected, data were analysed using Fisher's exact test.

RESULTS: The results showed two factors that influence the progression of HIV disease were HIV subtypes (p = 0.002) and Body Mass Index (p = 0.033). The HIV-1 subtype also correlated with CD4+ levels with a value of p = 0.04.

CONCLUSION: HIV-1 subtype correlates with HIV progression, so it is necessary to develop HIV/AIDS management strategies and clinical counselling.