Investigating the Manifestation of Coronary Artery Disease and Determining the Role of Effective Factors in the Need for Pacemaker Insertion in These Patients

Authors

  • Mohammad Tayyebi Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mitra Danesh Sani Mashhad University of Medical Sciences, Mashhad, Iran
  • Hamid Reza Mashreghi Moghadam Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Arash Gholoobi Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Negar Morovatdar Department of Community Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Javad Ramezani Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

DOI:

https://doi.org/10.3889/oamjms.2019.608

Keywords:

Pacemaker, Coronary artery disease, Angiography

Abstract

BACKGROUND: Many patients who are candidates for a pacemaker are also at the same time risk factors for coronary artery disease such as high blood pressure, hypertension, diabetes, and hyperlipidemia, and therefore the probability of having coronary artery disease is significant. Effective diagnostic measures can be taken to prove the factors affecting the incidence of CAD in patients undergoing pacemakers at high-risk, including angiography. Therefore, it can prevent complications during and after pacemaker implantation, which leads to an increase in the quality of treatment in patients requiring pacemaker implantation.

AIM: Therefore, the purpose of this study was to determine the predictive factors of significant coronary artery disease in patients with pacemaker implantation to identify patients in need of coronary angiography at the time of pacemaker implantation.

METHODS: This retrospective study was carried out to examine the patients' files that were placed at the heart of Imam Reza Hospital during the period between March 2017 and September 2017. Demographic data, risk factors, echocardiography findings, and angiography, were collected and then recorded using a checklist. Statistical analysis was performed using SPSS software version 22 and Chi-square, and Mann-Whitney tests were used for determining significates variables.

RESULTS: A group of 102 patients who had undergone a permanent cardiac pacemaker insertion due to an atrioventricular (AV) Block were included in the study, and also coronary anatomy was determined coronary angiography. Based on the results, 13.7% of patients with cardiac pacemaker had obstructive coronary artery disease (stenosis > 70%). Factors affecting coronary artery stenosis on angiography include gender, chest pain, history of myocardial infarction, angioplasty, diabetes, smoking, history of aspirin intake, calcium blocker and Plavix, high hematocrit, ST elevation and ST depression in the ECG, and severe mitral regurgitation.

CONCLUSION: It seems that in most patients requiring permanent pacemaker insertion because of the atrioventricular (AV) Block, angiography does not change the patient's fate, and so can be ignored. However, in patients who have several risk factors from the listed above, coronary angiography is recommended during admission.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Rezende PC, Scudeler TL, da Costa LM, Hueb W. Conservative strategy for treatment of stable coronary artery disease. World j clin cases. 2015; 3(2):163-70. https://doi.org/10.12998/wjcc.v3.i2.163 PMid:25685763 PMCid:PMC4317610

Kivimäki M, Nyberg ST, Batty GD, Fransson EI, Heikkilä K, Alfredsson L, et al. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet. 2012; 380(9852):1491-97. https://doi.org/10.1016/S0140-6736(12)60994-5

Centers for Disease Control and Prevention, (CDC). Prevalence of coronary heart disease--United States, 2006-2010. MMWR. Morbidity and mortality weekly report. 2011; 60(40):1377-81.

Moran AE, Forouzanfar MH, Roth GA, Mensah GA, Ezzati M, Murray CJ, et al. Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010: the Global Burden of Disease 2010 study. Circulation. 2014; 129(14):1483-92. https://doi.org/10.1161/CIRCULATIONAHA.113.004042 PMid:24573352 PMCid:PMC4181359

Abdulla J, Abildstrom SZ, Gotzsche O, Christensen E, Kober L, Torp-Pedersen C. 64-multislice detector computed tomography coronary angiography as potential alternative to conventional coronary angiography: a systematic review and meta-analysis. Eur Heart J. 2007; 28:3042-50. https://doi.org/10.1093/eurheartj/ehm466 PMid:17981829

Yesil M, Arikan E, Postaci N, Bayata S, Yilmaz R. Locations of coronary artery lesions in patients with severe conduction disturbance. Int Heart J. 2008; 49(5):525-31. https://doi.org/10.1536/ihj.49.525 PMid:18971564

Hwang IC, Seo WW, Oh IY, Choi EK, Oh S. Reversibility of atrioventricular block according to coronary artery disease: results of a retrospective study. Korean Circ J. 2012; 42(12):816-22. https://doi.org/10.4070/kcj.2012.42.12.816 PMid:23323119 PMCid:PMC3539047

Cardoso R, Alfonso CE, Coffey JO. Reversibility of High-Grade Atrioventricular Block with Revascularization in Coronary Artery Disease without Infarction: A Literature Review. Case Rep Cardiol. 2016; 2016:1971803. https://doi.org/10.1155/2016/1971803 PMid:26925272 PMCid:PMC4746340

Erhardt L, Herlitz J, Bossaert L, Halinen M, Keltai M, Koster R, et al. Task force on the management of chest pain. Eur Heart J. 2002; 23(15):1153-76. https://doi.org/10.1053/euhj.2002.3194 PMid:12206127

Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016; 37(3):267-315. https://doi.org/10.1093/eurheartj/ehv320 PMid:26320110

Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013; 34(38):2949-3003. https://doi.org/10.1093/eurheartj/eht296 PMid:23996286

Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, et al. 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Eur Heart J. 2013; 34(29):2281-329. https://doi.org/10.1093/eurheartj/eht150 PMid:23801822

Tandoğan I, Yetkin E, Güray Y, Aksoy Y, Sezgin AT, Ozdemir R, et al. Distribution of coronary artery lesions in patients with permanent pacemakers. Anadolu Kardiyol Derg. 2002; 2(4):279-83.

Hsueh CW, Lee WL, Chen YT, Ting CT. The incidence of coronary artery disease in patients with symptomatic bradyarrhythmias. Jpn Heart J. 2001; 42(4):417-23. https://doi.org/10.1536/jhj.42.417 PMid:11693278

Brueck M, Bandorski D, Kramer W. Incidence of coronary artery disease and necessity of revascularization in symptomatic patients requiring permanent pacemaker implantation. Med Klin (Munich). 2008; 103(12):827-30. https://doi.org/10.1007/s00063-008-1130-z PMid:19099211

Rajappan K. Permanent pacemaker implantation technique: part I: arrhythmias. Heart. 2009; 95(3):259-64. https://doi.org/10.1136/hrt.2007.132753 PMid:19144885

Rajappan K. Permanent pacemaker implantation technique: part II. Heart. 2009; 95(4):334-42. https://doi.org/10.1136/hrt.2008.156372 PMid:19176569

Armaganijan LV, Toff WD, Nielsen JC, Andersen HR, Connolly SJ, Ellenbogen KA, et al. Are Elderly Patients at Increased Risk of Complications Following Pacemaker Implantation? A Meta-Analysis of Randomized Trials. Pacing Clin Electrophysiol. 2012; 35(2):131-134. https://doi.org/10.1111/j.1540-8159.2011.03240.x PMid:22040168

Alai MS, Beig JR, Kumar S, Yaqoob I, Hafeez I, Lone AA, et al. Prevalence and characterization of coronary artery disease in patients with symptomatic bradyarrhythmias requiring pacemaker implantation. Indian Heart J. 2016; 68(Suppl 3):S21-S25. https://doi.org/10.1016/j.ihj.2016.06.013 PMid:28038720 PMCid:PMC5198875

Ciaroni S, Bloch A, Albrecht L, Vanautryve B. Diagnosis of coronary artery disease in patients with permanent cardiac pacemaker by dobutamine stress echocardiography or exercise thallium-201 myocardial tomography. Echocardiography. 2000; 17(7):675-9. https://doi.org/10.1046/j.1540-8175.2000.00675.x PMid:11107204

Published

2019-07-31

How to Cite

1.
Tayyebi M, Danesh Sani M, Mashreghi Moghadam HR, Gholoobi A, Morovatdar N, Ramezani J. Investigating the Manifestation of Coronary Artery Disease and Determining the Role of Effective Factors in the Need for Pacemaker Insertion in These Patients. Open Access Maced J Med Sci [Internet]. 2019 Jul. 31 [cited 2024 Apr. 26];7(13):2108-13. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2019.608

Issue

Section

B - Clinical Sciences