The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer

Indri Windarti; Wirsma Arif Harahap; Ricvan Dana Nindrea; Eti Yerizel; Primaria Dewi Rustamadji

doi:10.3889/oamjms.2019.757

Authors

Indri Windarti Faculty of Medicine, Andalas University, Padang, Indonesia
Wirsma Arif Harahap Department of Surgical, Oncology Division, Faculty of Medicine, Andalas University, Dr M Djamil General Hospital, Padang, Indonesia
Ricvan Dana Nindrea Department of Public Health and Community Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia
Eti Yerizel Department of Biomolecular and Biochemistry, Faculty of Medicine, Andalas University, Padang, Indonesia
Primaria Dewi Rustamadji Department of Anatomical Pathology, Faculty of Medicine, Indonesia University, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2019.757

Keywords:

PTEN, Immunohistochemical, Breast cancer, Prognosis

Abstract

AIM: This study aims to determine the prognostic significance of phosphatase and tensin homolog (PTEN) loss in breast cancer.

METHODS: We conducted a meta-analysis study. Sample of this study were research articles that evaluated PTEN loss and prognosis in breast cancer patients. We searched for relevant studies published in PubMed and Proquest from January 2010 to July 2018. We reviewed studies that examined the association between immunohistochemical expression of PTEN and breast cancer prognosis using meta-analysis methods. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3).

RESULTS: There were 7 studies conducted a systematic review then continued to evaluate the association of PTEN loss and breast cancer prognosis by meta-analysis. There was a significant association of PTEN loss with poor prognosis of breast cancer (RR = 0.76 [95% CI 0.59-0.98 p <0.07), and there was not any significant publication bias for studies included.

CONCLUSION: This study confirmed PTEN loss is an important independent factor for breast cancer prognosis.