Genetic Polymorphism of C-262T Catalase and Susceptibility to Schizophrenia

Mostafa Saadat; Samane Safaie; Iraj Saadat

doi:10.3889/oamjms.2014.013

Authors

Mostafa Saadat Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran; Institute of Biotechnology, Shiraz University, Shiraz
Samane Safaie Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran; Institute of Biotechnology, Shiraz University, Shiraz
Iraj Saadat Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran; Institute of Biotechnology, Shiraz University, Shiraz

DOI:

https://doi.org/10.3889/oamjms.2014.013

Keywords:

Age at diagnosis, CAT, C-262T, Genetic polymorphism, Schizophrenia.

Abstract

Background: Catalase (CAT, OMIM: 115500) plays an integral role in the primary defence against oxidative stress. The T allele of the C-262T CAT polymorphism (rs1001179) is associated with lower activity of CAT. Here we investigated whether polymorphism of C-266T CAT was associated with susceptibility to schizophrenia.

Methods: The present study was performed on 363 (267 males, 96 females) in-patients with schizophrenia diagnosis, and a total of 363 (266 males, 97 females) healthy controls. The C-262T CAT genotypes were determined using RFLP-PCR method.

Results: Although the association between genotypes and susceptibility was not significant in both genders, there was significant interaction between gender and the TT genotype (P=0.035). The Log-rank test and the Kaplan-Meier survival analysis were used to evaluate the influence of C-262T genotypes on age at diagnosis (AAD) of schizophrenia. Mean AAD of the CC and CT+TT genotypes in males was 22.8 and 24.9 years, respectively. The difference was significant (c²=4.26, P=0.039). Difference of mean AAD of the CC (26.7 years) and CT+TT (27.3 years) genotypes among females was not significant (c²=0.02, P=0.896).

Conclusion: Different associations between gender groups might be at least in part interpreted by the effect of gender on the association between C-262T polymorphism and CAT gene expression.

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